A5032378795- Wnt/β-catenin signaling in development and cancer
- Hippo pathway signaling and YAP/TAZ
- Cancer-related gene regulation
- Microtubule and mitosis dynamics
- Developmental Biology and Gene Regulation
- Photosynthetic Processes and Mechanisms
- Pancreatic function and diabetes
- Protist diversity and phylogeny
Duke University
2003-2010
Wg/Wnt signals specify cell fates in both invertebrate and vertebrate embryos maintain stem-cell populations many adult tissues. Deregulation of the Wnt pathway can transform cells to a proliferative fate, leading cancer. We have discovered that two Drosophila proteins are crucial for cytokinesis second, largely independent, role restricting activity pathway. The fly homolog RacGAP1, Tumbleweed (Tum)/RacGAP50C, its binding partner, kinesin-like protein Pavarotti (Pav), negatively regulate...
Wnt signaling specifies cell fates in many tissues during vertebrate and invertebrate embryogenesis. To understand better how is regulated development, we have performed genetic screens to isolate mutations that suppress or enhance the fly homolog, wingless (wg). We find loss-of-function neural determinant SoxNeuro (also known as Sox-neuro, SoxN) partially wg mutant pattern defects. SoxN encodes a HMG-box-containing protein related Sox1, Sox2 Sox3 proteins, which been implicated patterning...
The Wingless (Wg)/Wnt signal transduction pathway directs a variety of cell fate decisions in developing animal embryos. Despite the identification many Wg components to date, it is still not clear how these elements work together generate cellular identities. In ventral epidermis Drosophila embryos, specifies cells secrete characteristic pattern denticles and naked cuticle that decorate larval at end embryonic development. We have used as our assay system series genetic screens identify new...
Wg/Wnt signals specify cell fates in both invertebrate and vertebrate embryos maintain stem-cell populations many adult tissues. Deregulation of the Wnt pathway can transform cells to a proliferative fate, leading cancer. We have discovered that two Drosophila proteins are crucial for cytokinesis second, largely independent, role restricting activity pathway. The fly homolog RacGAP1, Tumbleweed (Tum)/RacGAP50C, its binding partner, kinesin-like protein Pavarotti (Pav), negatively regulate...