A5100645648- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Pancreatic and Hepatic Oncology Research
- Fungal Biology and Applications
- Neuroendocrine Tumor Research Advances
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Anesthesia and Pain Management
- Phytochemical Studies and Bioactivities
- Pregnancy and preeclampsia studies
- Foot and Ankle Surgery
- Phytochemistry and Bioactive Compounds
- Flavonoids in Medical Research
- Cancer, Hypoxia, and Metabolism
- Orthopedic Surgery and Rehabilitation
- Ziziphus Jujuba Studies and Applications
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Microbial Metabolites in Food Biotechnology
- Spine and Intervertebral Disc Pathology
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Chromatography in Natural Products
- Diabetic Foot Ulcer Assessment and Management
- Phytoestrogen effects and research
The People's Hospital of Guangxi Zhuang Autonomous Region
2024-2025
First Affiliated Hospital of GuangXi Medical University
2023-2025
Guangxi Medical University
2023-2025
Ningxia Medical University
2023-2025
Second Affiliated Hospital of Soochow University
2020-2024
Beijing Radiation Center
2023-2024
Tianjin University of Traditional Chinese Medicine
2021-2024
Academy of Military Medical Sciences
2021-2024
University of Bern
2024
Soochow University
2020-2024
Objectives This study aimed to develop and validate intratumoral, peritumoral, combined radiomic models based on endoscopic ultrasonography (EUS) for retrospectively differentiating pancreatic neuroendocrine tumors (PNETs) from cancer. Methods A total of 257 patients, including 151 with cancer 106 PNETs, were retroactively enrolled after confirmation through pathological examination. These patients randomized either the training or test cohort in a ratio 7:3. Radiomic features extracted...
Background Gastric cancer is the world’s leading tumor disease in terms of morbidity and mortality currently treated clinically with a comprehensive approach based on surgery. Studies have demonstrated antitumor effects neferine, but anti-cancer mechanism for gastric not yet clear. Methods The Pubchem Swiss TargetPrediction databases were searched to retrieve targets action neferine. Meanwhile, relevant gene expression data downloaded by means Gene Expression Omnibus(GEO) database screen...
Ferroptosis, a recently proposed form of regulated cell death, is characterized by surge in reactive oxygen species and subsequent depletion glutathione. The mitochondria nucleoli play pivotal roles the process ferroptosis. Therefore, monitoring interactions between during ferroptosis crucial for clarifying its physiological pathological processes. In this study, we designed synthesized near-infrared fluorescence probe MINU, which exhibits excellent stability against biological ions pH...
Gastric cancer (GC) is a common gastrointestinal malignancy worldwide. Based on cancer-related mortality, the current prevention and treatment strategies for GC still show poor clinical results. Therefore, it important to find effective drug targets.To explore molecular mechanism of 18β-glycyrrhetinic acid (18β-GRA) regulating miR-345-5p/TGM2 signaling pathway inhibit proliferation cells.CCK-8 assay was used determine effect 18β-GRA survival rate GES-1 cells AGS HGC-27 cells. Cell cycle...
<p id="p00010">Ziziphi Spinosae Semen refers to the dried seed of <italic>Ziziphus jujuba</italic> Mill. var. <italic>spinosa</italic> (Bunge) Hu ex H. F. Chou. The is composed a reddish brown coat and yellow kernel. A comparative study was conducted investigate differences in chemical composition their relative contents between kernel Ziziphi Semen. First, compounds found were characterized identified using ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry...
Pachymic acid (PA) is derived from Poria cocos. PA has a variety of pharmacological and inhibitory effects on various tumors. However, the mechanism action in gastric cancer (GC) remains unclear.
BACKGROUND Cancer is one of the most serious threats to human health worldwide. Conventional treatments such as surgery and chemotherapy are associated with some drawbacks. In recent years, traditional Chinese medicine treatment has been increasingly advocated by patients attracted attention from clinicians, become an indispensable part comprehensive for gastric cancer. AIM To investigate mechanism Xiaojianzhong decoction (XJZ) in cancer (GC) utilizing network pharmacology experimental...
Gastric cancer (GC) is one of the most common types worldwide, and its prevention treatment methods have garnered much attention. As active ingredient licorice, 18β-glycyrrhetinic acid (18β-GRA) has a variety pharmacological effects. The aim this study was to explore effective target 18β-GRA in GC, order provide ideas for clinical GC.
This study sought to assess and compare the clinical efficacy complications of a modified sinus tarsi approach (MSTA) extensile lateral (ELA) in treatment displaced intra-articular calcaneal fractures.This retrospective enrolled 108 patients (117 feet) with Sanders II-IV fractures, including 52 (56 MSTA group 56 (61 ELA group. The functional radiological results affected feet were analysed retrospectively. Functional evaluation included American Orthopaedic Foot Ankle Society (AOFAS), visual...
Tumor necrosis factor-α (TNF-α) antagonists, the first biologics approved for treating patients with inflammatory bowel disease (IBD), are effective induction and maintenance of remission significantly improving prognosis. However, up to one-third treated show primary nonresponse (PNR) anti-TNF-α therapies, 23%-50% IBD experience loss response (LOR) these during subsequent treatment. There is still no recognized predictor evaluating efficacy anti-TNF drugs. This review summarizes existing...
Background: Artesunate (ART) has been recognized to induce ferroptosis in various tumor phenotypes, including neuroendocrine tumors. We aimed investigate the effects of ART on insulinoma and underlying mechanisms by focusing process ferroptosis. Methods: The CCK8 colony formation assays were conducted assess effectiveness ART. Lipid peroxidation, glutathione, intracellular iron content determined validate ferroptosis, while ferrostatin-1 (Fer-1) was employed as inhibitor Subcutaneous models...
The Developmental Origins of Health and Disease hypothesis sustains that exposure to different stressors during prenatal development prepares the offspring for challenges be encountered after birth. We studied gestational period as a particularly vulnerable window where can have strong implications fetal programming offspring's life-long metabolic status via alterations specific placentally expressed nutrient transporters. To study this mechanism, we used murine stress model, human...