A5077866571- Advanced ceramic materials synthesis
- Advanced materials and composites
- Aluminum Alloys Composites Properties
- MicroRNA in disease regulation
- Intermetallics and Advanced Alloy Properties
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Rock Mechanics and Modeling
- Autophagy in Disease and Therapy
- Quinazolinone synthesis and applications
- Natural product bioactivities and synthesis
- NF-κB Signaling Pathways
- Asphalt Pavement Performance Evaluation
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Metallurgy and Material Forming
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Microstructure and mechanical properties
- Smart Grid and Power Systems
- Curcumin's Biomedical Applications
- Laser and Thermal Forming Techniques
- Power Systems and Renewable Energy
- Cancer, Lipids, and Metabolism
- Bioactive Natural Diterpenoids Research
Yanbian University
2019-2025
Hong Kong Polytechnic University
2021-2025
Shenzhen Polytechnic
2021-2025
Shenzhen Technology University
2025
Ningxia Medical University
2023-2025
First People's Hospital of Chongqing
2024
Dalian University of Technology
2005-2024
CM Hospital
2024
Zhejiang University of Technology
2024
Chengdu University of Technology
2010-2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to have devastating consequences worldwide. Recently, great efforts been made identify SARS-CoV-2 host factors, but the regulatory mechanisms of these molecules, as well virus per se, remain elusive. Here we report a role RNA G-quadruplex (RG4) in infection. Combining bioinformatics, biochemical and biophysical assays, demonstrate presence RG4s both genome factors. The biological pathological importance is then...
Abstract Endoplasmic reticulum (ER) stress can trigger various cell death mechanisms beyond apoptosis, providing promise in cancer treatment. Oncosis, characterized by cellular swelling and increased membrane permeability, represents a non-apoptotic form of death. In our study, we discovered that Arnicolide D (AD), natural sesquiterpene lactone compound, induces ER stress-mediated oncosis hepatocellular carcinoma (HCC) cells, this process is reactive oxygen species (ROS)-dependent....
Benefiting from the evolution of nanotechnology, combination therapy by gene interference and reactive oxygen species (ROS) scavenging are expected, which holds great potential in inflammatory bowel disease (IBD) therapy. However, functional integration different therapeutic modules through interface modification vectors for safe efficient treatment is urgently needed. Herein, we present a catechol chemistry-mediated core-shell nanoplatform ROS scavenging-mediated oxidative stress...
The induction of cell death is recognized as a potent strategy for cancer treatment. Apoptosis an extensively studied form death, and multiple anticancer drugs exert their therapeutic effects by inducing it. Nonetheless, apoptosis evasion hallmark cancer, rendering cells resistant to chemotherapy drugs. Consequently, there growing interest in exploring novel non-apoptotic forms such ferroptosis, necroptosis, pyroptosis, paraptosis. Natural compounds with properties have garnered significant...
The Akt/mTORC1 pathway plays a central role in the activation of Warburg effect cancer. Here, we present for first time that halofuginone (HF) treatment inhibits colorectal cancer (CRC) growth both vitro and vivo through regulation signaling pathway. Halofuginone human CRC cells inhibited cell proliferation, induced generation reactive oxygen species apoptosis. As expected, reduced level NADPH was also observed, at least part due to inactivation glucose-6-phosphate dehydrogenase pentose...
5-Hydroxytryptamine (5-HT), a neurotransmitter and vasoactive factor, has been reported to promote proliferation of serum-deprived hepatocellular carcinoma (HCC) cells but the detailed intracellular mechanism is unknown. As Wnt/β-catenin signalling highly dysregulated in majority HCC, this study explored regulation by 5-HT. The expression various 5-HT receptors was studied quantitative real-time polymerase chain reaction (qPCR) HCC cell lines as well 33 pairs tumours corresponding adjacent...
Propanethiol (PT) is a hazardous pollutant that poses risks to both the environment and human well-being.
Supramolecular polymers driven by the metal-ligand coordination possess reversible bonds, making them promising candidates for integrating therapeutic functions of metal ions and small-molecule drugs, subsequently releasing these components within cells after endocytosis. In this study, a kind supramolecular polymer, SHICU, is developed, composed Shikonin ligand Cu(II) ion. Upon reduction intracellular glutathione (GSH), SHICU dissociates to release Shikonin, Cu(II), fragments. The released...
Cancer remains a significant global health challenge, with current chemotherapeutic strategies frequently limited by the emergence of resistance. In this context, natural compounds potential to overcome resistance have garnered considerable attention. Among these, sesquiterpene lactones, primarily derived from plants in Asteraceae family, stand out for their anticancer properties. This review specifically focuses on five key signaling pathways: PI3K/Akt/mTOR, NF-κB, Wnt/β-catenin, MAPK/ERK,...
Background Gastric cancer is the world’s leading tumor disease in terms of morbidity and mortality currently treated clinically with a comprehensive approach based on surgery. Studies have demonstrated antitumor effects neferine, but anti-cancer mechanism for gastric not yet clear. Methods The Pubchem Swiss TargetPrediction databases were searched to retrieve targets action neferine. Meanwhile, relevant gene expression data downloaded by means Gene Expression Omnibus(GEO) database screen...
NF-κB-inducing kinase (NIK) is a central component in the non-canonical NF-κB signaling pathway. Excessive NIK activity implicated various disorders, such as autoimmune conditions and cancers. Here, we report first crystal structure of truncated human complex with adenosine 5′-O-(thiotriphosphate) at resolution 2.5 Å. This protein catalytically active construct, including an N-terminal extension 60 residues prior to domain, 20 afterward. The reveals that domain assumes conformation absence...
// Guoqing Chen 1, 2, * , Ruihong Gong Xianli Shi 3 Dajian Yang 2 Ge Zhang 1 Aiping Lu Jianbo Yue Zhaoxiang Bian School of Chinese Medicine, Hong Kong Baptist University, Kong, China Chongqing Academy Materia Medica, Chongqing, Department Biomedical Sciences, City University These authors have contributed equally to this work Correspondence to: Yue, email: jianbyue@cityu.edu.hk Bian, bzxiang@hkbu.edu.hk Keywords: halofuginone, artemisinin, synergy, cell proliferation, cycle Received:...
Background Rodents are recognized as the hosts of many vector-borne bacteria and protozoan parasites play an important role in their transmission maintenance. Intensive studies have focused on infections vectors, especially ticks, however, bacterial rodents poorly understood although human cases presenting with fever may due to infection been found. Methods From May October 2019, 192 wild were trapped environment Guangxi Province, spleen samples collected reveal presence them. The...