A5108059449- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Pancreatitis Pathology and Treatment
- RNA Interference and Gene Delivery
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- RNA modifications and cancer
- RNA Research and Splicing
- Signaling Pathways in Disease
- RNA and protein synthesis mechanisms
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Drug Transport and Resistance Mechanisms
- Diet and metabolism studies
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Ubiquitin and proteasome pathways
- Genomics and Chromatin Dynamics
- Endoplasmic Reticulum Stress and Disease
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Inflammasome and immune disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autophagy in Disease and Therapy
Sichuan University
2016-2025
Air Force Medical University
2014-2025
Xijing Hospital
2014-2025
West China Hospital of Sichuan University
2018-2024
State Key Laboratory of Biotherapy
2015-2024
Guangxi University of Science and Technology
2023
Wuhou District People's Hospital, Chengdu
2023
City Of Hope National Medical Center
2010-2022
Dalian Medical University
2022
Lanzhou University
2022
Type 2 diabetes (T2D) is characterized by insulin resistance and increased hepatic glucose production, yet the molecular mechanisms underlying these abnormalities are poorly understood. MicroRNAs (miRs) a class of small, noncoding RNAs that have been implicated in regulation human diseases, including T2D. miR-26a known to play critical role tumorigenesis; however, its function cellular metabolism remains unknown. Here, we determined regulates signaling lipids. Compared with lean individuals,...
Abstract Ferroptosis is a nonapoptotic cell death process that requires cellular iron and the accumulation of lipid peroxides. In progressive rheumatoid arthritis (RA), synovial fibroblasts proliferate abnormally in presence reactive oxygen species (ROS) elevated oxidation. Here we show, using collagen-induced (CIA) mouse model, imidazole ketone erastin (IKE), ferroptosis inducer, decreases fibroblast numbers synovium. Data from single-cell RNA sequencing further identify two groups have...
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease characterized by excessive proliferation of fibroblasts and accumulation extracellular matrix (ECM). Ferroptosis novel form cell death the lethal iron lipid peroxidation, which associated with many diseases. Our study addressed potential role played ferroptosis in progression fibrosis. We found that inducers injury, namely, bleomycin (BLM) lipopolysaccharide (LPS), induced lung epithelial cells. Both inhibitor...
Clinical staining and targeting CREB3L1 facilitates precise stratification a potential treatment strategy for thyroid cancer.
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by interacting with the 3′ untranslated region (3′-UTR) of multiple mRNAs. Recent studies have linked miRNAs to development cancer metastasis. In this study, we show miR-194 is specifically expressed in human gastrointestinal tract and kidney. Moreover, highly hepatic epithelial cells, but not Kupffer cells or stellate two types mesenchymal liver. was decreased hepatocytes cultured vitro, which had undergone a...
Significance Ten eleven translocation (TET) enzymes are recently identified proteins that mediate DNA demethylation, but their regulation is still unknown. This paper indicates a microRNA, miR-26a, able to directly target TETs and then modulate 5-hydroxymethylcytosine levels. Furthermore, of by miR-26a shown promote pancreatic cell differentiation both in vitro vivo. These results highlight link between miRNA, stem/progenitor differentiation. It also suggests potential approach increase the...
Abstract Signet-ring cell carcinoma (SRCC) has specific epidemiology and oncogenesis in gastric cancer, however, with no systematical investigation for prognostic genomic features. Here we report a systematic conducted 1868 Chinese cancer patients indicating that signet-ring cells content was related to multiple clinical characteristics treatment outcomes. We thus perform whole-genome sequencing on 32 pairs of SRC samples, identify frequent CLDN18-ARHGAP26/6 fusion (25%). With 797 additional...
Type 2 diabetes (T2D) is characterized by insulin resistance along with pancreatic β cell failure. factors are traditionally thought to control glucose homeostasis modulating levels, not sensitivity. Exosomes emerging as new regulators of intercellular communication. However, the role β-cell–derived exosomes in metabolic poorly understood. Here, we report that microRNA-26a (miR-26a) cells only modulates secretion and replication an autocrine manner but also regulates peripheral sensitivity a...
The mixed lineage kinase domain like (MLKL) protein, receptor interacting protein (RIPK) 1, and RIPK3 are key regulators of necroptosis, a highly pro-inflammatory mode cell death that has been implicated in various pathological processes human diseases. However, the role these necroptotic diabetes remains unknown. Here we sought to delineate MLKL insulin resistance type 2 (T2D).We first analyzed expression obese/diabetic mouse models. We then utilized knockout (MLKL-/-) mice evaluate effects...
SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape, compromising the effectiveness of existing vaccines neutralizing antibodies. An in-depth investigation on COVID-19 pathogenesis is urgently needed develop a strategy against variants. Here, we identified CD147 as universal receptor for its Meanwhile, Meplazeumab, humanized anti-CD147 antibody, could block cellular entry variants-alpha, beta, gamma, delta, with inhibition rates 68.7, 75.7, 52.1, 62.3% at 60...
Pyroptosis is a lytic form of pro-inflammatory cell death characterised as caspase 1 dependent with canonical NLRP3 inflammasome-induced gasdermin D (GSDMD) activation. We aimed to investigate the role acinar pyroptotic in pancreatic injury and systemic inflammation AP.Pancreatic pathway activation upon toxin stimulation vitro vivo was investigated. Effects pharmacological (NLRP3 caspase-1 inhibitors), constitutive (Nlrp3-/- , Casp1-/- Gsdmd-/- ) conditional (Pdx1Cre Nlrp3Δ/Δ Pdx1Cre...
Metastasis is the main cause of cancer‐related death, yet underlying mechanisms are still poorly understood. Long noncoding RNAs (lncRNAs) emerging as crucial regulators malignancies; however, their functions in tumor metastasis remain largely unexplored. In this study, we identify a lncRNA, termed metabolism‐induced activator 1 ( MITA1 ), which up‐regulated hepatocellular carcinoma (HCC) and contributes to metastasis. , chromatin‐enriched lncRNA discovered by our nuclear RNA sequencing,...
Objective The systemic spread of colorectal cancer (CRC) is dominated by the portal system and exhibits diverse patterns metastasis without systematical genomic investigation. Here, we evaluated evolution CRC with multiorgan metastases using multiregion sequencing. Design Whole-exome sequencing was performed on multiple regions (n=74) matched primary tumour, adjacent non-cancerous mucosa, liver lung from six patients CRC. Phylogenetic reconstruction evolutionary analyses were used to...
Abstract B cell dysfunction due to obesity can be associated with alterations in the levels of micro-RNAs (miRNAs). However, role miRNAs these processes remains elusive. Here, we show that miR-802 is increased pancreatic islets obese mouse models and demonstrate inducible transgenic overexpression mice causes impaired insulin transcription secretion. We identify Foxo1 as a factor promoting its transcription, NeuroD1 Fzd5 targets -dependent silencing. Repression β primary impairs reduction...
Impaired diabetic wound healing is associated with the persistence of chronic inflammation and excessive oxidative stress, which has become one most serious clinical challenges. Wound dressings anti-inflammatory reactive oxygen species (ROS)-scavenging properties are desirable for treatment. In this study, a shape-adaptable, biodegradable, biocompatible, antioxidant, immunomodulatory interleukin-33 (IL-33)-cytogel developed by encapsulating IL-33 into physically cross-linked DNA hydrogels...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to have devastating consequences worldwide. Recently, great efforts been made identify SARS-CoV-2 host factors, but the regulatory mechanisms of these molecules, as well virus per se, remain elusive. Here we report a role RNA G-quadruplex (RG4) in infection. Combining bioinformatics, biochemical and biophysical assays, demonstrate presence RG4s both genome factors. The biological pathological importance is then...
The development of a biodegradable and shape-adaptable bioscaffold that can enhance local cytokine retention bioactivity is essential for the application immunotherapy in periodontal diseases. Here, we report biodegradable, anti-inflammatory, osteogenic ILGel uses physically cross-linked DNA hydrogel as soft long-term sustained release interleukin-10 (IL-10) to accelerate diabetic alveolar bone rebuilding. Porous microstructures favored encapsulation IL-10 maintained at least 7 days. be...
Abstract COVID‐19 patients can develop clinical and histopathological features associated with fibrosis, but the pathogenesis of fibrosis remains poorly understood. CD147 has been identified as a universal receptor for SARS-CoV-2 its variants, which could initiate COVID-19-related cytokine storm. Here, we systemically analyzed lung in SARS-CoV-2- delta variant-infected humanized transgenic mice. Histopathology Transmission Electron Microscopy revealed inflammation, fibroblast expansion...
Background and Aims: Extrachromosomal circular DNAs (eccDNAs) are prevalent in cancer genomes emerge as a class of crucial yet less characterized oncogenic drivers. However, the structure, composition, genome-wide frequency, contribution eccDNAs HCC, one most fatal cancers, remain unexplored. In this study, we provide comprehensive characterization human HCC demonstrate an role microRNA (miRNA)-17-92-containing tumor progression. Approach Results: Using circle-sequencing method, identify...