A5032109314- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Catalysis and Hydrodesulfurization Studies
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Magnetic Properties of Alloys
- Cancer, Lipids, and Metabolism
- Nanomaterials for catalytic reactions
- Polysaccharides and Plant Cell Walls
- Immune Cell Function and Interaction
- Signaling Pathways in Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Click Chemistry and Applications
- Peptidase Inhibition and Analysis
- Metal-Organic Frameworks: Synthesis and Applications
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Diet, Metabolism, and Disease
- Lung Cancer Treatments and Mutations
- Hippo pathway signaling and YAP/TAZ
- Magnetic and transport properties of perovskites and related materials
- Chemical Reactions and Isotopes
- Berberine and alkaloids research
Lanzhou University
2021-2025
First Hospital of Lanzhou University
2021-2025
Air Force Medical University
2017-2025
Xijing Hospital
2022-2025
Shangqiu First People's Hospital
2022-2024
Rega Institute for Medical Research
2023-2024
Kailuan General Hospital
2015-2024
Union Hospital
2023-2024
Jilin University
2023-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2019-2024
Focal adhesion plays an essential role in tumour invasiveness and metastasis. Hippo component YAP has been widely reported to be involved many aspects of biology. However, its focal regulation breast cancer remains unexplored.Tissue microarray was used evaluate expression clinical specimens by immunohistochemical staining. Cell migration invasion abilities were measured Transwell assay. A cell assay measure the ability gelatin. The visualized through immunofluorescence. Phosphorylated FAK...
SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape, compromising the effectiveness of existing vaccines neutralizing antibodies. An in-depth investigation on COVID-19 pathogenesis is urgently needed develop a strategy against variants. Here, we identified CD147 as universal receptor for its Meanwhile, Meplazeumab, humanized anti-CD147 antibody, could block cellular entry variants-alpha, beta, gamma, delta, with inhibition rates 68.7, 75.7, 52.1, 62.3% at 60...
Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Blocking via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication. Meplazumab is humanized IgG
Abstract COVID‐19 patients can develop clinical and histopathological features associated with fibrosis, but the pathogenesis of fibrosis remains poorly understood. CD147 has been identified as a universal receptor for SARS-CoV-2 its variants, which could initiate COVID-19-related cytokine storm. Here, we systemically analyzed lung in SARS-CoV-2- delta variant-infected humanized transgenic mice. Histopathology Transmission Electron Microscopy revealed inflammation, fibroblast expansion...
Hepatic immunity is one of the driving forces for development nonalcoholic steatohepatitis (NASH), and targeting gut microbiota believed to affect hepatic immune constitution. Here, we aimed investigate immunological state in NASH, with a specific emphasis on natural killer (NK) cells. In addition, identify contributing species that target provide new directions support feasibility immunotherapy NASH. A possible NASH population was determined by combination long-term severe fatty liver,...
Vascular restenosis is a serious clinical issue initiated and aggravated by macrophage inflammation, with no effective treatments available, in cardiovascular autoimmune diseases. However, the untapped mechanisms new targets that can regulate polarization vascular remain elusive. The research identifies interferon regulatory factor 4 (IRF4) expression as crucial during arterial restenosis. Myeloid-specific Irf4 deficiency overexpression experiments showed IRF4 promoted M2 polarization,...
In view of the current situation high cost and low catalytic efficiency commercial Pd-based catalysts, adding transition metals (Ni, Co, etc.) to form Pd-M bimetallic catalyst not only reduces consumption Pd but also greatly improves activity stability, which has attracted increasing attention. this work, three-dimensional network Pd–Ni catalysts were prepared successfully by a liquid-phase in situ reduction method with hydroxylated γ-Al2O3 as support. Through investigating effects precursor...
BackgroundCuproptosis is a novel form of cellular demise that occurs through unique pathway involving lipoylated proteins in the tricarboxylic acid (TCA) cycle and closely linked to mitochondrial metabolism. Nevertheless, comprehensive elucidation impact carcinogenesis-associated genes (CRGs) on prognosis, tumor microenvironment (TME), therapeutic response patients with gastric cancer (GC) remains unclear.MethodsIn total, 1374 GC samples were gathered from three Gene Expression Omnibus (GEO)...