A5003537990- Cancer-related molecular mechanisms research
- RNA regulation and disease
- RNA Research and Splicing
- Soybean genetics and cultivation
- Legume Nitrogen Fixing Symbiosis
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Fibroblast Growth Factor Research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Ferroptosis and cancer prognosis
- Advanced Glycation End Products research
- Cell death mechanisms and regulation
- Plant Disease Resistance and Genetics
- Traditional Chinese Medicine Analysis
- Gut microbiota and health
- Immune Response and Inflammation
- Wheat and Barley Genetics and Pathology
- Cancer, Hypoxia, and Metabolism
- Business Process Modeling and Analysis
- Circular RNAs in diseases
Central South University
2020-2025
Second Xiangya Hospital of Central South University
2020-2025
South China Agricultural University
2025
Guangdong Academy of Agricultural Sciences
2025
Guiyang Medical University
2025
First Affiliated Hospital of Guangzhou Medical University
2025
State Key Laboratory of Respiratory Disease
2025
Guangzhou Medical University
2025
Shandong University
2025
Huazhong University of Science and Technology
2014-2024
With prospective clinical sequencing of tumors emerging as a mainstay in cancer care, there is an urgent need for support tool that distills the implications associated with specific mutation events into standardized and easily interpretable format. To this end, we developed OncoKB, expert-guided precision oncology knowledge base.
Abstract Plants have evolved sophisticated mechanisms for integration of endogenous and exogenous signals to adapt the changing environment. Both phytohormones jasmonate (JA) ethylene (ET) regulate plant growth, development, defense. In addition synergistic regulation root hair development resistance necrotrophic fungi, JA ET act antagonistically gene expression, apical hook curvature, defense against insect attack. However, molecular mechanism such antagonism between signaling remains...
Despite the high therapeutic response achieved with B-cell maturation antigen (BCMA)-specific chimeric receptor (CAR) T-cell therapy in relapsed and refractory multiple myeloma (R/R MM), primary resistance relapse exist single-target immunotherapy. Here, we design bispecific BC19 CAR T cells targeting BCMA/CD19 evaluate antimyeloma activity vitro vivo. Preclinical results indicate that specifically recognize target antigens, mediate selective killing of BCMA or CD19-positive cancer cells....
Mitochondrial Ca2+ plays a critical role in tumorigenesis, including cell proliferation and metastasis. calcium uniporter regulator 1 (MCUR1) has been shown to be frequently upregulated HCC promote cancer survival. However, whether MCUR1 is involved the metastasis of its underlying mechanisms remain unknown. The effect expression on epithelial-mesenchymal transition (EMT) cells was first evaluated by immunofluorescent staining Western blot. Then, vitro invasion vivo assays were used evaluate...
Plants generate protective molecules in response to ultraviolet (UV) light. In laboratory experiments, 48 h UV-B irradiation of peach fruits and leaves reduced the flavour-related monoterpene linalool by 60%. No isoprene was detected, but other terpenoids increased significantly, including a threefold accumulation sesquiterpene (E,E)-α-farnesene, which also jasmonic acid treatment. RNA sequencing revealed altered transcript levels for two terpene synthases (TPSs): PpTPS1, TPS-g subfamily...
Soybean is a major crop that provides an important source of protein and oil to humans animals, but its production can be dramatically decreased by the occurrence drought stress. Soybeans survive stress if there robust deep root system at early vegetative growth stage. However, little known about genome-wide molecular mechanisms contributing soybean architecture. This study was performed gain knowledge on transcriptome changes related development under water limited conditions.The Williams...
Adenosine/adenosine receptor-mediated signaling has been implicated in the development of various ischemic diseases, including retinopathies. Here, we show that adenosine A2a receptor (ADORA2A) promotes hypoxia-inducible transcription factor-1 (HIF-1)-dependent endothelial cell glycolysis, which is crucial for pathological angiogenesis proliferative Adora2a expression markedly increased retina mice with oxygen-induced retinopathy (OIR). Endothelial cell-specific, but not macrophage-specific...
Abstract Senescent astrocytes accumulate with aging and contribute to brain dysfunction diseases such as Alzheimer's disease (AD), however, the mechanisms underlying senescence of during remain unclear. In present study, we found that Yes‐associated Protein (YAP) was downregulated inactivated in hippocampal mice AD model mice, well D‐galactose paraquat‐induced senescent astrocytes, a Hippo pathway‐dependent manner. Conditional knockout YAP significantly promoted premature including reduction...
Cuproptosis, a newly identified form of programmed cell death, is thought to play role in tumorigenesis. Long non-coding RNAs (lncRNAs) are reported be associated with tumor progression and prognosis colon adenocarcinoma (COAD). However, the prognostic value cuproptosis-related lncRNAs COAD remains unknown. This study devoted constructing validating lncRNA signature that can predict patient outcomes using bioinformatics methods.The mRNA expression profiles corresponding clinical data were...
Accumulation of foam cells in the neointima represents a key event atherosclerosis. We previously demonstrated that Tanshinone IIA (Tan), lipophilic bioactive compound extracted from Salvia miltiorrhiza Bunge, inhibits experimental atherogenesis, yet detailed mechanisms are not fully understood. In this study, we sought to explore potential effects Tan on lipid accumulation macrophage and underlying molecular mechanisms. Our data indicate treatment reduced content macrophages, cholesterol...
Sulforaphane (SFN) is reported to reduce the accumulation of lipids. However, underling mechanism remains unclear. In this study, potential SFN improve lipid metabolism investigated through altering mitochondrial function and biogenesis-related mechanisms.The abnormal model was established both in HHL-5 cells rats by feeding a high-fat diet (HFD) for 10 weeks. The current findings suggest that alleviates swelling mitochondria stimulates biogenesis. reduced expression NRF1 TFAM, were reversed...
Background and Purpose Cryptotanshinone ( CTS ) is a major bioactive diterpenoid isolated from Danshen, an eminent medicinal herb that used to treat cardiovascular disorders in Asian medicine. However, it not known whether can prevent experimental atherosclerosis. The present study was designed investigate the protective effects of on atherosclerosis its molecular mechanisms action. Experimental Approach Apolipoprotein E‐deficient ApoE −/− mice, fed atherogenic diet, were dosed daily with...
Jasmonates (JAs), lipid-derived phytohormones, regulate plant growth, development and defenses against biotic stresses. CORONATINE INSENSITIVE1 perceives bioactive JA recruits JASMONATE ZIM-DOMAIN (JAZ) proteins for ubiquitination subsequent degradation via the 26S proteasome, which de-represses JAZ-targeted transcription factors that diverse responses. Recent studies showed Arabidopsis basic helix-loop-helix factor MYC5 interacts with JAZs regulates stamen development. However, whether...
Molecular markers of clinical outcome may aid in designing targeted treatments for bladder cancer. However, only a few cancer biomarkers have been examined as therapeutic targets.Data from The Cancer Genome Atlas (TCGA) and specimens were evaluated to determine the biomarker potential hyaluronic acid (HA) family molecules - HA synthases, receptors hyaluronidase. efficacy 4-methylumbelliferone (4MU), synthesis inhibitor, was vitro xenograft models.In TCGA data sets, synthases hyaluronidase-1...
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. Although dysbiosis and gut microbiota have been associated with NSCLC, their relative contributions are unclear; in addition, roles distant metastasis (DM) still illusive. We recruited total 121 participants, including 87 newly diagnosed treatment-naive NSCLC patients various stages 34 healthy volunteers, surveyed fecal sputum microbiota. compared microbial profiles between groups, identified...