A5030900462- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- Sirtuins and Resveratrol in Medicine
- High-Energy Particle Collisions Research
- Signaling Pathways in Disease
- Particle Accelerators and Free-Electron Lasers
- Mitochondrial Function and Pathology
- Particle Detector Development and Performance
- Eicosanoids and Hypertension Pharmacology
- Autophagy in Disease and Therapy
- RNA regulation and disease
- Peroxisome Proliferator-Activated Receptors
- EEG and Brain-Computer Interfaces
- PARP inhibition in cancer therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Atherosclerosis and Cardiovascular Diseases
- Adipose Tissue and Metabolism
- Cancer-related gene regulation
- Cholesterol and Lipid Metabolism
- Neural Networks and Applications
- Wind and Air Flow Studies
- Antioxidant Activity and Oxidative Stress
- Blind Source Separation Techniques
- Nitric Oxide and Endothelin Effects
- Metabolism, Diabetes, and Cancer
Sun Yat-sen University
2016-2025
Harbin Institute of Technology
2016-2022
Sunshine Coast University Hospital
2021
University of the Sunshine Coast
2021
Guangzhou University of Chinese Medicine
2021
Nankai University
2021
The University of Melbourne
2021
Northeastern University
2021
Cleveland Clinic Lerner College of Medicine
2021
National Medical Products Administration
2021
The present study identified a novel mechanism underlying the protective effect of Sirtuin 3 (SIRT3) against pathological cardiac hypertrophy, beyond its well-accepted role as deacetylase in mitochondria. SIRT3 modulates peroxisomes-mitochondria interplay by preserving expression peroxisomal biogenesis factor 5 (PEX5), thereby improving mitochondrial function. Downregulation PEX5 was observed hearts Sirt3−/− mice and angiotensin II-induced hypertrophic mice, well cardiomyocytes with...
Premature senescence of vascular endothelial cells is a leading cause various cardiovascular diseases. Therapies targeting would have important clinical implications. The present study was aimed to evaluate the potential heme oxygenase-1 (HO-1) as therapeutic target for senescence.Upregulation HO-1 by Hemin or adenovirus infection reversed H2O2-induced in human umbilical vein (HUVECs); whereas depletion siRNA inhibitor protoporphyrin IX zinc (II) (ZnPP) triggered HUVEC senescence....
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity worldwide. Cigarette smoking, which leads to abnormalities in the airways or alveoli and persistent obstruction airway's flow, significant risk factor COPD. Cryptotanshinone (CTS) active ingredient Salvia miltiorrhiza (Danshen) has many pharmacological properties including anti-inflammatory, antitumor, antioxidant properties, but its impact on COPD uncertain. In present study, potential effect CTS was investigated...
Abstract A high proportion of patients with stable angina remains symptomatic despite multiple treatment options. Di'ao Xinxuekang (XXK) capsule and Compound Danshen (CDS) tablet have been approved for treating pectoris more than 20 years in China. We compare the anti-anginal effectiveness XXK CDS chronic angina. randomized, multicenter, double-blind, parallel-group, superiority trial was conducted 4 study sites. 733 were included full analysis set. The primary outcomes who angina-free...
SIRT6 is a member of the sirtuin family class III histone deacetylases. It plays important roles in regulating genomic stability, metabolism, stress response and aging. Our previous study has revealed that attenuates myocardial hypertrophy by inhibiting NF-κB activation, but related molecular mechanisms remain to be clarified. In present study, we showed p300 acetylase was involved protective effect against phenylephrine (PE)-induced cardiomyocyte hypertrophy. cultured neonatal rat...
Endothelial cell senescence is the main risk factor contributing to vascular dysfunction and progression of aging-related cardiovascular diseases. However, relationship between endothelial metabolism remains unclear. The present study provides novel insight into fatty acid in regulation senescence. In replicative model H2O2-induced premature primary cultured human umbilical vein cells (HUVECs), oxidation (FAO) was suppressed profile disturbed, accompanied by downregulation proteins...
Background and Purpose Activation of PKC‐ζ is closely linked to the pathogenesis cardiac hypertrophy. can be activated by certain lipid metabolites such as phosphatidylinositol (3,4,5)‐trisphosphate ceramide. However, its endogenous negative regulators are not well defined. Here, role sirtuin1‐PKC‐ζ signalling axis underlying molecular mechanisms were investigated in Experimental Approach Cellular hypertrophy cultures myocytes, from neonatal Sprague‐Dawley rats, was monitored measuring cell...
The activation of signal transducer and activator transcription 3 (STAT3) is critical for the development cardiac hypertrophy heart failure. Sirtuin 6 (SIRT6) protects cardiomyocytes from hypertrophy. This study focused on association between SIRT6 STAT3 in regulation cardiomyocyte In phenylephrine (PE)-induced hypertrophic model hearts isoprenaline-induced rat model, mRNA protein expressions its phosphorylated level at tyrosine 705 (P-STAT3) were significantly increased. By contrast,...
The orphan nuclear receptor NOR1 belongs to the NR4A subfamily of hormone superfamily, and is involved in glucose fat metabolism. However, its potential contribution cardiovascular diseases remains be assessed. Here, roles cardiac hypertrophy induced by isoprenaline underlying molecular mechanisms were investigated.NOR1 was expressed cardiomyocytes treated with isoprenaline. After overexpression or knockdown neonatal rat cardiomyocytes, cellular monitored measuring cell surface area mRNA...
Seed-mediated growth has emerged as an effective approach to the synthesis of noble-metal nanocrystals with well-controlled sizes, shapes, compositions, and structures. Although surface capping is known affect pattern a seed, its explicit role remains be fully understood. In this article, we applied collision model established for science seed-mediated in effort account heterogeneous nucleation atoms on seed thus presence or absence agent. Using Pd cubic seeds system, demonstrated that only...
NFATc4, a member from the Nuclear Factor of Activated T cells (NFATs) transcription factor family, plays pivotal role in development cardiac hypertrophy. NFATc4 is dephosphorylated by calcineurin and translocated cytoplasm to nucleus regulate expression hypertrophic genes, like brain natriuretic polypeptide (BNP). The present study identified SIRT6, an important subtype NAD+ dependent class Ⅲ histone deacetylase, be negative regulator cardiomyocyte In phenylephrine (PE)-induced model,...
High serum level of palmitic acid(PA) is implicated in pathogenesis cardiovascular diseases. PA serves as the substrate for protein palmitoylation. However, it still unknown whether palmitoylation involved PA-induced dysfunction. Here, clinical cohort studies 1040 patients with coronary heart disease, high associated risk major adverse events (MACE) and death. In ApoE