Pulmonary artery hypertension (PAH) is characterized by vascular remodeling, high pulmonary blood pressure, and right ventricular hypertrophy. Oxidative stress, inflammation remodeling are important components in PAH. Ellagic acid (EA) a phenolic compound with anti-oxidative, anti-inflammatory, anti-proliferative properties. This study aimed to investigate whether EA could prevent the development of monocrotaline (MCT)-induced PAH rats.Male Sprague-Dawley rats received (30 50mg/kg/day) or...

Monocytes or macrophages have been assessed as potential therapeutics to ameliorate myocardial ischemic diseases, but the results controversial. As regulatory macrophages, M2b could enhanced protective effects. We tested hypothesis that transplantation of ischemia/reperfusion (I/R) injury. The mechanisms involved in it were investigated.M2b polarized by lipopolysaccharide (LPS) and immune complex (IC) from bone marrow-derived (BMDMs) C57BL/6 mice. They identified based on surface marker...

Macrophages play an important role in the development of cardiac fibrosis. However, roles different macrophage subtypes fibroblast (CF) activation and fibrosis are unknown.

Whether the preoperative anemia affects prognosis and therapeutic choice between coronary artery bypass grafting (CABG) or medical therapy alone in patients with ischemic cardiomyopathy (ICM) remains unclear. We assess influence of on long-term outcomes ICM treated without CABG. Patients hemoglobin were included from Surgical Treatment Ischemic Heart Failure (STICH) trial. The primary outcome was all-cause mortality. A total 1,209 enrolled, 320 (26.5%) anemia, 889 (73.5%) anemia. median...

Structural changes of the left and right atria associated with atrial fibrillation (AF) in mitral stenosis (MS) patients are well known, alterations microRNA (miRNA) expression profiles have also been investigated. However, miRNA still require delineation. This study evaluated tissues from MS AF relative to those normal sinus rhythm (NSR). Sample appendages were obtained 12 (6 AF) during valve replacement surgery. From these tissues, created analyzed using a human microarray. Results...

The atrial fibrillation (AF) associated microRNAs (miRNAs) were found in the right atrium (RA) and left (LA) from patients with rheumatic mitral valve disease (RMVD). However, most studies only focus on RA; potential differences of AF-associated miRNAs between RA LA are still unknown. aim this study was to perform miRNA expression profiles analysis compare appendages (RAA) (LAA) RMVD patients.Samples tissues RAA LAA obtained 18 (10 AF) during replacement surgery. From these tissues, created...

Cardiac fibrosis is a significant global health problem with limited treatment choices. Although previous studies have shown that imatinib (IMA) inhibited cardiac fibrosis, the anti-fibrotic mechanisms not been clearly uncovered. The aim of this study to evaluate whether IMA attenuates by inhibiting platelet-derived growth factor receptors (PDGFR) on isoproterenol (ISO)-induced mice. Adult male C57BL/6 mice were treated vehicle or ISO ± for one week. After echocardiography examination,...

The effects of mesenchymal stem cell (MSC)-derived exosomes on brain microvascular endothelial cells under oxygen-glucose deprivation (OGD), which mimic in deep hypothermic circulatory arrest (DHCA) vitro, are yet to be studied.MSCs were co-cultured with primary rat cells, then exposed OGD. Cell viability, apoptosis, the inflammatory factors (IL-1β, IL-6, and TNF-α), activation inflammation-associated TLR4-mediated pyroptosis NF-κB signaling pathway determined. Furthermore, derived from MSCs...

Aims: To evaluate the prognostic value of preoperative lymphocyte-to-monocyte ratio (LMR) in patients who underwent cardiac surgery. Methods: Clinical data were extracted from Medical Information Mart for Intensive Care III (MIMIC-III) database. The optimal cutoff LMR was determined by X-tile software. Cox proportional hazard model applied identification independent factors 4-year mortality and survival curves estimated using Kaplan-Meier method. In order to balance influence potential...

Abstract Background MicroRNAs were enrolled in various cardiovascular disease especially ischemic heart diseases, but the microRNA changes during myocardial ischemia reperfusion injury underwent cardiopulmonary bypass are still unknown. This study screens differences CPB canines and evaluates relationship of microRNAs with injury. Methods 13 healthy received 60 minutes aortic clamping cardioplegic arrest, followed by 90 reperfusion. Left ventricular samples, blood samples hemodynamic data...

Abstract Background and Aim Laryngopharyngeal reflux (LPR) is caused by the of gastric contents beyond esophagus into larynx pharynx. However, upper esophageal sphincter (UES) motility proximal parameters are poorly studied. This study aims to explore characteristics UES parameter among LPR patients. Methods Patients with laryngopharyngeal symptoms only (L), patients typical (L + E), (E), healthy controls (H) were retrospectively included. Physiological profiles studied compared groups using...

Background: High morbidity and mortality caused by rheumatic heart disease (RHD) are global burdens, especially in low-income developing countries. Whether mitral valve repair (MVP) benefits RHD patients remains controversial. Thus, we performed a meta-analysis to compare the perioperative long-term outcomes of MVP replacement (MVR) patients. Methods Results: A systematic literature search was conducted major databases, including Embase, PubMed, Cochrane Library, until 17 December 2020....

Despite novel improvements in the diagnosis and treatment of infective endocarditis (IE), there has been no significant improvement survival rate IE, which indicates that many details still need to be optimized preoperative assessment. We sought evaluate serum albumin as a biomarker for predicting early mortality after IE surgery.Between October 2013 June 2019, patients with definite were enrolled this study. Patients' levels at admission used levels. Restricted cubic spline multivariate...

Immunity and inflammation are considered to be central features of pulmonary artery hypertension (PAH), in which macrophages one the main components inflammatory cell infiltration around artery. M2b macrophages, different from M1 M2 believed have immunomodulatory activities produce little fibrosis. The purpose this study was explore effect on smooth muscle cells (PASMCs) derived monocrotaline-induced PAH rats.PASMCs were cultured serum-free medium, supernatant M0 or for 24 hours. Then...

Valve-sparing aortic root replacement (VSARR), which includes reimplantation and remodeling techniques, has been developed as an important treatment for aneurysms. We aimed to evaluate the outcomes of versus techniques in valve-sparing surgery aneurysms.A systematic review meta-analysis was performed by searching PubMed, Embase Cochrane Library until November 2019. Fourteen retrospective cohort studies comparing with aneurysms were included contained at least one following outcomes: early...

This study aimed to investigate whether selective antegrade cerebral perfusion or retrograde is a better technique for brain protection in deep hypothermic circulatory arrest by obtaining metabolic evidence from microdialysis.Randomized, animal study.Assisted circulation laboratory.Eighteen piglets of either sex (9.8 ± 3.1 kg).Animals were randomly assigned 40 minutes at 18°C without (deep group, n = 6) with (selective (retrograde 6). Reperfusion was continued 3 hours.Microdialysis (glucose,...

The pathogenesis of atrial fibrillation (AF) remains unclear. Vascular endothelial growth factors (VEGFs) can stimulate fibrosis within the atrium and ventricle. We hypothesized that there is a relationship between serum VEGFs/soluble vascular factor receptor (sVEGFRs) levels AF in patients with valvular heart disease (VHD). This provides new paradigm for studying AF.The plasma VEGF-A, VEGF-C, sVEGFR-1 sVEGFR-2 were detected by enzyme-linked immunosorbent assay (ELISA). A total 100 people,...

Achalasia is a primary esophageal motility disorder with heterogeneous manometric subtypes and prognosis, characterized by degeneration of the myenteric plexus, reduction in interstitial cells Cajal (ICCs). This study aimed to explore histopathologic characteristics lower sphincter (LES) muscle from patients achalasia different prognosis.We examined specimens LES 122 who underwent peroral endoscopic myotomy 10 control esophagectomy for cancer. Hematoxylin-eosin staining was performed assess...

Abstract Background Vein grafts are commonly employed in revascularisation surgery for multivessel coronary artery disease, yet neointimal hyperplasia (NIH) remains a critical impediment to the long‐term patency of these grafts. Despite this, effective methods precisely identify and target interventions neointima still inadequate. Methods In this study, Sprague–Dawley (SD) rats were used establish an external jugular vein transplantation model, NIH pathophysiological process was tracked...

To clarify the characteristics of TCR alphabeta T cells in peripheral blood patients with chronic hepatitis B (CHB), we investigated patterns Complementarity Determining Region3 (CDR3) length distribution for all 24 BV gene families and 32 AV family lymphocytes two CHB healthy controls by immunoscope spectratyping technique. We found that profiles CDR3 showed Gaussian (the polyclonal cells) controls, however, restricted usage oligoclonal has been monitored patients, furthermore, different...

Aortic regurgitation is a severe cardiovascular complication of Behcet's disease, resulting in high mortality rates within the Asian population. Standard surgical interventions have resulted poor results long term. We herein report on modified aortic valve replacement technique coupled with reinforcement wall. During this procedure, Teflon felts and continuous mattress stitches were used to reinforce wall order prevent prosthetic detachment formation an pseudoaneurysm. Postoperative...

Up to 50% of the patients suspected reflux laryngitis syndrome failed respond acid suppression therapy. However, predictors success have not been determined.Consecutive with chronic were enrolled prospectively. All underwent laryngoscopy, esophagogastroduodenoscopy and 24-h multichannel intraluminal impedance pH (MII-pH) monitoring before receiving rabeprazole 10 mg b.i.d. for 3 months. Patient was considered as a responder if chief laryngeal complaint score during last week since interview...