A5101680722- Marine Bivalve and Aquaculture Studies
- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Hepatitis B Virus Studies
- Environmental Toxicology and Ecotoxicology
- Physiological and biochemical adaptations
- Calcium Carbonate Crystallization and Inhibition
- Protein Hydrolysis and Bioactive Peptides
- Biological Research and Disease Studies
- Hepatitis C virus research
- Meat and Animal Product Quality
- Immune Cell Function and Interaction
- Trace Elements in Health
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Gastrointestinal Tumor Research and Treatment
- Liver Disease Diagnosis and Treatment
- HIV, Drug Use, Sexual Risk
- Genomics, phytochemicals, and oxidative stress
- Aquatic Invertebrate Ecology and Behavior
- Studies on Chitinases and Chitosanases
- Enzyme function and inhibition
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
Institute of Oceanology
2011-2024
Chinese Academy of Sciences
2012-2024
Qingdao National Laboratory for Marine Science and Technology
2016-2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2024
Nanyang Medical College
2020-2024
Southern Medical University
2006-2024
Nanfang Hospital
2022-2024
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2024
Institute of Hydrobiology
2024
University of Chinese Academy of Sciences
2020-2024
Abstract Helicobacter pylori , particularly cytotoxin-associated gene A (CagA)-positive strains, plays a key role in the progression of gastric cancer (GC). Ferroptosis, associated with lethal lipid peroxidation, has emerged to play an important malignant and infectious diseases, but CagA ferroptosis cells not been determined. Here, we report that confers GC sensitivity both vitro vivo. Mechanistically, promotes synthesis polyunsaturated ether phospholipids (PUFA-ePLs), which is mediated by...
Few safety and effectiveness results have been published regarding the administration of tenofovir alafenamide fumarate (TAF) during pregnancy for prevention mother-to-child transmission (MTCT) hepatitis B virus (HBV).In this multicenter prospective observational study, pregnant women with HBV DNA levels higher than 200 000 IU/mL who received TAF or disoproxil (TDF) from gestational weeks 24-35 to delivery were 1:1 enrolled followed until postpartum month 6. Infants immunoprophylaxis. The...
The Pacific oyster Crassostrea gigas is an important marine fishery resource, which contains high levels of glycogen that contributes to the flavor and quality oyster. However, little known about molecular chemical mechanisms underlying content differences in oysters. Using a homogeneous cultured family, we explored these regulatory networks at level metabolome transcriptome.Oysters with highest lowest natural were selected for differential transcriptome analysis. We identified 1888...
Recently, cultivation of the Pacific abalone Haliotis discus hannai (Ino, 1953) in China has developed rapidly, boosted by innovations low-cost seed production and highly efficient sea-based culture systems. Seed differs between northern southern is dependent on sufficient quantities broodstock, excess freshly cultured diatoms during nursery phase, tank hygiene newly designed attachment methodology intermediate phase. Innovations grow-out systems for abalone, such as stock enhancement...
Mollusk shell is one kind of potential biomaterial, but its vague mineralization mechanism hinders further application. matrix proteins are important functional components that embedded in the shell, which play roles formation. The proteome oyster had been determined based on genome sequence by our group and gives chance for deep study this area. classical model formation posits mantle-secreted. But, study, we analyzed data combination with organ transcriptome found may be produced multiple...
The Pacific oyster (Crassostrea gigas) is one of the most important aquaculture species worldwide. Its meat quality vital for consumer satisfaction, and nutrient content, especially glycogen, closely associated with fatness colour. Fluctuations in content short-term starvation have not been previously reported, seasonal variation glycogen different tissues has rarely reported. In present study, we investigated these aspects production found that (50 hr) did significantly alter protein or...
The effect of temperature on the immune response was studied in abalone (Haliotis discus hannai) reared seawater at 8, 14 and 26°C for 30 days, with maintained optimum (20°C) serving as control. total haemocyte count (THC) 8°C treatment group significantly higher than control (P < 0.05). A 0.05) lower phagocytic capacity observed 8 14°C groups. Reactive oxygen species (ROS) production haemocytes that group. Real-time RT-PCR analyses indicated highest level serine protease inhibitor (Spi)...
Liver injuries have been reported in patients with coronavirus disease 2019 (COVID-19). This study aimed to investigate the clinical role played by severe acute respiratory syndrome 2 (SARS-CoV-2).In this multicentre, retrospective study, parameters of liver function tests COVID-19 inpatients were compared between various time-points reference SARS-CoV-2 shedding, and 3 7 days before first detection viral shedding was regarded as baseline.In total, 70 enrolled. Twenty-two (31.4%) had a...
The condition index (CI) is an economically important tool for assessing the quality of oysters, such as Pacific oyster Crassostrea gigas. However, little known about mechanisms that underlie differences in CI between different C. gigas populations. In this study, we integrated transcriptomic and metabolomic profiling to investigate high- low-CI groups one- two-year-old populations results indicate were associated with regulation growth-related genes, FoxO signaling pathway, complex...
High glycogen levels in the Pacific oyster (Crassostrea gigas) contribute to its flavor, quality, and hardiness. Glycogenin (CgGN) is priming glucosyltransferase that initiates biosynthesis. We characterized full sequence function of C. gigas CgGN. Three CgGN isoforms (CgGN-α, β, γ) containing alternative exon regions were isolated. expression varied seasonally adductor muscle gonadal area was highest muscle. Autoglycosylation can interact with synthase (CgGS) complete synthesis. Subcellular...
Association of tumor microenvironment and immune checkpoint (e.g., PD-L1) is important for escape, impacting chemotherapy immunotherapy efficacy. We aimed to investigate biomarkers therapeutic targets against treatment resistance in gastric cancer. Abundances tumor-infiltrating cells were estimated multiple datasets. Three patient subgroups (A, B, C) identified based on seven types PD-L1- IFN-γ-associated cells. Patients yielded increased prognosis from subgroup A C (p = 0.027). Subgroup was...
To clarify the characteristics of TCR alphabeta T cells in peripheral blood patients with chronic hepatitis B (CHB), we investigated patterns Complementarity Determining Region3 (CDR3) length distribution for all 24 BV gene families and 32 AV family lymphocytes two CHB healthy controls by immunoscope spectratyping technique. We found that profiles CDR3 showed Gaussian (the polyclonal cells) controls, however, restricted usage oligoclonal has been monitored patients, furthermore, different...
INTRODUCTION: The course of maternal antiviral prophylaxis to prevent mother-to-child transmission hepatitis B virus (HBV-MTCT) varies greatly, and it has not been demonstrated in a randomized controlled study. METHODS: In this multicenter, open-label, trial, eligible pregnant women with HBV DNA 5.3–9.0 log 10 IU/mL who received tenofovir alafenamide fumarate (TAF) from the first day 33 gestational weeks delivery (expected 8 week) or 4 postpartum 12 were randomly enrolled at 1:1 ratio...