A5101555127- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Hepatitis B Virus Studies
- Heat shock proteins research
- Cancer, Hypoxia, and Metabolism
- Natural Compounds in Disease Treatment
- Water Quality Monitoring Technologies
- Hepatitis C virus research
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Analysis
- Flavonoids in Medical Research
- RNA modifications and cancer
- Chromatography in Natural Products
- Enzyme Catalysis and Immobilization
- Parkinson's Disease Mechanisms and Treatments
- Natural product bioactivities and synthesis
- Bone Metabolism and Diseases
- Phytochemistry and Biological Activities
- Telomeres, Telomerase, and Senescence
- Viral-associated cancers and disorders
- Neural Networks and Applications
- Connective tissue disorders research
- Invertebrate Immune Response Mechanisms
- Sarcoma Diagnosis and Treatment
Southern University of Science and Technology
2025
Harbin Medical University
2017-2025
Fourth Affiliated Hospital of Harbin Medical University
2017-2025
Chengde Medical University
2021-2024
Luohe Medical College
2021-2024
Zhejiang University of Technology
2022-2024
Beijing Luhe Hospital Affiliated to Capital Medical University
2024
Henan Polytechnic University
2024
Shandong University
2023-2024
State Key Laboratory of Microbial Technology
2023-2024
Glioblastoma multiforme (GBM) is a malignant cancer with severely poor survival, and the cells continue to thrive during hypoxia toxic stress through autophagy. To validate oncogenic role of long noncoding RNA H19 in GBM progression examine whether autophagy and/or miR-491-5p participate process. The expression autophagy-related genes healthy control tissues was assessed via quantitative polymerase chain reaction. In addition, cell viability, proliferation, apoptosis were respectively...
We aimed to study the anti-tumor effects of triptolide on osteosarcoma and related molecular mechanisms. The cell viability, apoptosis portion, tumor size, weight, invasion cells were determined. relative level microRNA-181 in tissues adjacent was determined by quantitative real-time reverse transcription polymerase chain reaction. target gene microRNA-181a verified luciferase report assay. At last, treated with + mimics verify relationship between microRNA-181a. Triptolide inhibited...
Collecting hyperspectral data of licorice from different origins, processing the in three methods, and using multiple classifiers for origin classification, results showed that U-Net method could effectively improve accuracy classification.
Citri Exocarpium Rubrum and Reticulatae Pericarpium were successfully distinguished by the characteristic fingerprint UHPLC-Q-TOF MS methods.
Long noncoding RNA (LncRNA) H19 has been proven to be involved in many kinds of cancers including glioma, and a previous study shown an autophagy regulation H19. The mammalian target rapamycin (mTOR) signaling pathway plays key role Unc-51 like activating kinase 1 (ULK1) is also thought signaling. In our study, we investigated the mTOR/ULK1 H19-mediated promotion glioma proliferation. Human cells U87 U251 normal human astrocytes HA1800 were used study. First, expression was determined U87,...
MicroRNAs (miRNAs) are involved in the progression of diverse human cancers. This work aimed to delve into how microRNA-135a-5p (miR-135a-5p) affects biological behaviors Breast Cancer (BC) cells. Gene Expression Omnibus (GEO) datasets were used analyze expression differences miR-135a-5p cancer tissues BC patients. Quantitative real-time PCR and western blot conducted detect Bcl-2 Associated Athanogene (BAG3) levels cells, respectively. The proliferation, migration, invasion, cell cycle...
Objective Growth differentiation factor 15 (GDF-15) is a stress-responsive cytokine that regulates myocardial injury, cardiac overloading pressure, and inflammation related to the risk of cardiovascular diseases events. The current study aimed investigate correlation GDF-15 levels with clinical features, biochemical indices, especially cardiotoxicity in breast cancer patients receiving neoadjuvant dual anti-HER2 therapy. Methods A total 103 HER2-positive who underwent therapy (trastuzumab...
This study utilized the lipidomics strategy combined with quantification of neurotransmitters, oxidative stress, and inflammation level to reveal therapeutic mechanism ESL for ischemic stroke.
Schisandra chinensis (Turcz.) Baill Fructus (SCF) is the ripe fruit of Baill, and often used as a neuroprotective drink. Modern pharmacological studies have shown that lignans are main bioactive components responsible for neuroprotection potential in treatment Alzheimer's disease (AD). However, mechanism action SCF AD from pharmacokinetics-pharmacodynamics (PK-PD) perspective remains not well established. The purpose this study to investigate compare pharmacokinetic differences normal rats,...