A5008391277- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Analytical Chemistry and Chromatography
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Mass Spectrometry Techniques and Applications
- Chromatography in Natural Products
- Alzheimer's disease research and treatments
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Tryptophan and brain disorders
- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- Traditional Chinese Medicine Studies
- Saffron Plant Research Studies
- Amyotrophic Lateral Sclerosis Research
- Cholinesterase and Neurodegenerative Diseases
- Plant-derived Lignans Synthesis and Bioactivity
- Flavonoids in Medical Research
- Food Quality and Safety Studies
- Plant-based Medicinal Research
- Gout, Hyperuricemia, Uric Acid
- DNA and Nucleic Acid Chemistry
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
Changchun Institute of Applied Chemistry
2015-2024
Chinese Academy of Sciences
2015-2024
Changchun University
2023
University of Science and Technology of China
2019-2022
The Affiliated Hospital to Changchun University of Chinese Medicine
2022
State Key Laboratory of Electroanalytical Chemistry
2019
NOAA Chemical Sciences Laboratory
2017
University of Chinese Academy of Sciences
2014
Jilin University
2013
In vitro α-glucosidase inhibition assays and ultrafiltration liquid chromatography with photodiode array detection coupled to electrospray ionization tandem mass spectrometry (ultrafiltration LC-DAD-ESI-MSn) were combined screen inhibitors from hawthorn leaf flavonoids extract (HLFE). As a result, four compounds identified as in the HLFE, their structures confirmed be quercetin-3-O-rha- (1-4)-glc-rha C-glycosylflavones (vitexin-2″-O-glucoside, vitexin-2″-O-rhamnoside vitexin) by...
Electrospray ionization multi-stage tandem mass spectrometry (ESI-MS(n)) and liquid chromatography coupled with on-line (LC/MS/MS) were applied to characterize saponins in crude extracts from Panax ginseng. The MS(n) data of the [M - H](-) ions can provide structural information on sugar sequences saccharide chains sapogins saponins. By ESI-MS(n), non-isomeric isomeric different aglycones be determined rapidly plant extracts. LC/MS/MS is a good complementary analytical tool for determination...
The underivatized saponins from Tribulus terrestris and Panax ginseng have been investigated by electrospray ionization multi-stage tandem mass spectrometry (ESI-MS(n)). In ESI-MS spectra, a predominant [M + Na](+) ion in positive mode - H](-) negative were observed for molecular information. Multi-stage of the ions was used detailed structural analysis. Fragment glycoside cleavage can provide information on aglycone primary sequence branching oligosaccharide chains terms classes...
ABSTRACT Introduction Acanthopanax senticosus Harms is a typical Chinese herb with flavonoids existing in all parts of the plant but largest content leaves. However, leaves have been neglected past research. To investigate potential use A. for discovering lead compounds to treat type 2 diabetes, were selected screening α‐glucosidase inhibitors. Objective screen candidates inhibitors from and evaluate structure–activity relationship Methodology Ultrafiltration liquid chromatography/mass...
This study was designed to investigate the antagonism of SCP in Aβ25–35-induced AD rats by intervening neurotransmitters and metabolites.
Abstract It remains particularly difficult for gaining unambiguous information on anomer, linkage and position isomers of oligosaccharides using conventional mass spectrometry (MS) methods. In our laboratory, an ion mobility (IM) shift strategy was employed to improve confidence in the identification structurally closely related disaccharide monosaccharide IMMS. Higher separation between structural achieved 1-phenyl-3-methyl-5-pyrazolone (PMP) derivatization comparison with phenylhydrazine...
Therapeutic effects and potential mechanism of action homogeneous polysaccharide SCP2 on AD rats.
By blending hexanediol with caprylic/capric triglyceride, we created a full-component extract of Crithmum maritimum , which could promote epidermal regeneration.
Abstract A reversed‐phase high‐performance liquid chromatography‐diode array detector‐electrospray ionization multiple‐stage tandem mass spectrometry (RP‐HPLC‐DAD‐ESI‐MS n ) method has been developed for the detection and analysis of lignan constituents in methanol extract from fruits Schisandra chinensis (Turcz.) Baill. RP‐HPLC‐DAD‐ESI‐MS electrospray Fourier transform ion cyclotron resonance (ESI‐FT‐ICR‐MS have applied to investigate characteristic product ions four reference compounds....
Misfolding and aggregation of Cu, Zn superoxide dismutase (SOD1) is implicated in the etiology amyotrophic lateral sclerosis (ALS). The use small molecules may stabilize spatial structure SOD1 dimer, thus, preventing its dissociation aggregation. In this study, "native" mass spectrometry (MS) was used to study noncovalent interactions between flavonoid compounds. MS experiments were performed on a quadruple time-of-flight (Q-ToF) spectrometer with an electrospray ionization (ESI) source...
Modern studies have indicated Gardenia jasminoides Ellis (G. jasminoides) showed positive effect in treating type 2 diabetes mellitus (T2DM). In this study, 60 streptozotocin-induced T2DM rats were divided into four groups: control group, geniposide-treated total iridoid glycosides-treated and crude extraction of gardenlae fructus-treated group. The other ten healthy the During 12 weeks treatment, rat's feces samples collected for metabolomics study based on mass spectrometry technique. On...