A5084385656- Metabolomics and Mass Spectrometry Studies
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Traditional Chinese Medicine Analysis
- Neurological Disease Mechanisms and Treatments
- Gut microbiota and health
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects of Natural Compounds
- Eicosanoids and Hypertension Pharmacology
- Peroxisome Proliferator-Activated Receptors
- Plant-based Medicinal Research
- Essential Oils and Antimicrobial Activity
- Plant biochemistry and biosynthesis
- Oral microbiology and periodontitis research
- Phytochemistry and Biological Activities
- Liver Disease Diagnosis and Treatment
- Antioxidant Activity and Oxidative Stress
- Chromatography in Natural Products
- Alkaloids: synthesis and pharmacology
- Food Quality and Safety Studies
Jilin University
2018-2024
Jilin Medical University
2018-2021
Scope Cerebral ischemia‐reperfusion (IR) injury stands as a prominent global contributor to disability and mortality. Nervonic acid (NA), bioactive elongated monounsaturated fatty acid, holds pivotal significance in human physiological well‐being. This research aims explore the prophylactic effects fundamental mechanisms of NA rat model cerebral IR injury. Methods results Through induction middle artery occlusion, this study establishes comprehensively assesses pharmacodynamic impacts...
Citri Exocarpium Rubrum and Reticulatae Pericarpium were successfully distinguished by the characteristic fingerprint UHPLC-Q-TOF MS methods.
Gancao Xiexin Decoction (GCXXD) is a traditional Chinese decoction that often used in treating gastric ulcers. However, the substance basis and mechanism of action remain unclear. In this study, vivo vitro components GCXXD were analyzed by ultra‐high‐performance liquid chromatography coupled with quadrupole‐orbitrap mass spectrometry. The compound Discover platform was to ultimately enable rapid identification compounds. Acquire X intelligent data acquisition technology software innovatively...
The leaves of <italic>Acanthopanax Senticosus</italic> Harms (<italic>ASL</italic>) can be used as a food ingredient and also raw materials for making tea wine.
The therapeutic material basis and effect of ASL in the treatment ischemic stroke were studied by PK-PD analysis.
This study utilized the lipidomics strategy combined with quantification of neurotransmitters, oxidative stress, and inflammation level to reveal therapeutic mechanism ESL for ischemic stroke.
Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. leaves (ESL) are widely used to treat ischemic stroke (IS); however, the specific mechanism remains unclear. The microbiota-gut-brain axis plays a critical role in IS and has become potential therapeutic target. This study aimed reveal verify effect of ESL on through axis. Ultra-high-performance liquid chromatography coupled with mass spectrometry-based untargeted/targeted metabolomics combined 16S rRNA microbiota sequencing strategy were...