A5101819384- Plant Gene Expression Analysis
- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Plant biochemistry and biosynthesis
- Berberine and alkaloids research
- Lipid metabolism and biosynthesis
- Plant Reproductive Biology
- Plant Stress Responses and Tolerance
- Ginger and Zingiberaceae research
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Pancreatic function and diabetes
- Ionic liquids properties and applications
- COVID-19 Clinical Research Studies
- Cholesterol and Lipid Metabolism
- Plant-Microbe Interactions and Immunity
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Plant tissue culture and regeneration
- Chromatography in Natural Products
- Autophagy in Disease and Therapy
- Chemical and Physical Properties in Aqueous Solutions
- Natural Products and Biological Research
- Robotic Locomotion and Control
Tongji Hospital
2017-2025
Huazhong University of Science and Technology
2017-2025
Dalian Minzu University
2019-2024
Chinese Academy of Sciences
2007-2022
Dalian Institute of Chemical Physics
2019-2022
Shanghai Jiao Tong University
2021
Dalian University of Technology
2015-2017
Dalian University
2015-2017
Dalian Polytechnic University
2011
Liaoning University
2007
Elevated levels of plasma free fatty acid (FFA) and disturbed mitochondrial dynamics play crucial roles in the pathogenesis diabetic kidney disease (DKD).However, mechanisms by which FFA leads to damage glomerular podocytes DKD effects Berberine (BBR) on are not fully understood.Methods: Using db/db mice model cultured mouse podocytes, we investigated molecular mechanism FFA-induced disturbance testified BBR regulating dysfunction, podocyte apoptosis glomerulopathy progression DKD.Results:...
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic and characterized by excessive hepatic lipid accumulation. Many studies have suggested that overload key initial factor contributes to steatosis. Our previous study indicated diosgenin (DSG) has a beneficial effect on energy metabolism, but underlying mechanism remains unclear.Human normal hepatocytes (LO2 cells) were incubated with palmitic acid establish cell model of nonalcoholic liver. The effects DSG glucose uptake...
Background: Intestinal mucosal barrier dysfunction plays an important role in the development of diabetes mellitus (DM). Berberine (BBR), a kind isoquinoline alkaloid, is widely known to be effective for both DM and diarrhea. Here, we explored whether anti-diabetic effect BBR was related intestine barrier. Methods Results: The rat model T2DM established by high glucose fat diet feeding intravenous injection streptozocin. Then, those diabetic rats were treated with at different concentrations...
Background Memory-impairment was one of the common characteristics in patients with diabetes mellitus. The release chronic inflammation mediators and insulin resistance diabetic brain gave rise to generation toxic factor Aβ42 which marker Alzheimer's disease (AD). In addition, impairment memory mellitus also correlated predominantly uptake/metabolism glucose medial prefrontal cortex (mPFC). Previously, anti-inflammation hypoglycemic effects berberine have been described peripheral tissues....
Abstract Backgrounds Inflammation is recognized as the key pathological mechanism of type 2 diabetes. The hypoglyceamic effects berberine (BBR) are related to inhibition inflammatory response, but not completely clear. Methods polarization Raw264.7 cells and primary peritoneal macrophages were induced by LPS, then underlying mechanisms BBR explored. An model was established LPS treatment at different concentrations for time. ELISA assay used detect secretions TNF-α. RT-PCR applied M1...
Abstract Background Low free triiodothyronine (FT3) levels are related to a poor prognosis deterioration in patients with COVID-19 presenting non-thyroidal illness syndrome (NTI). This study was designed explore whether thyroxin (FT4) or thyroid stimulating hormone (TSH) affected the mortality of NTI. Methods Patients complicated NTI who were treated at our hospital included this retrospective study. divided into low TSH and normal groups, as well normal-high FT4 group, according reference...
Photoperiod-dependent male fertility is a critical enabler of modern hybrid breeding. A MYB transcription factor, CSA, key regulator sugar partitioning in rice anthers, disruption which causes photoperiod-sensitive sterility. However, little known about the molecular mechanisms governing plant response to photoperiod. Here, we have obtained another sterile mutant, csa2, exhibits semi-sterility under long-day (LD) conditions, with normal short-day (SD) conditions. CSA2 specifically expressed...
Excessive synthesis of triglycerides and cholesterol accelerates the progression hepatic steatosis in metabolic-associated fatty liver disease (MAFLD). However, precise mechanism by which 6-gingerol mitigates MAFLD model mice has yet to be fully understood. The present study observed that administration exhibited significant protective effects against obesity, insulin resistance, subjected a high-fat diet (HFD), mitigated lipid accumulation HepG2 cells treated with palmitate (PA). Following...
Scope Cerebral ischemia‐reperfusion (IR) injury stands as a prominent global contributor to disability and mortality. Nervonic acid (NA), bioactive elongated monounsaturated fatty acid, holds pivotal significance in human physiological well‐being. This research aims explore the prophylactic effects fundamental mechanisms of NA rat model cerebral IR injury. Methods results Through induction middle artery occlusion, this study establishes comprehensively assesses pharmacodynamic impacts...
Camellia oleifera Abel is a highly valued woody edible oil tree, which endemic to China. It has great economic value because C. seed contains high proportion of polyunsaturated fatty acids. anthracnose caused by Colletotrichum fructicola , poses serious threat growth and yield causes the benefit industry suffer directly. The WRKY transcription factor family members have been widely characterized as vital regulators in plant response pathogen infection. Until now, number, type biological...
Environmental conditions, such as photoperiod and temperature, can affect male fertility in plants. While this feature is heavily exploited rice to generate male-sterile lines for hybrid breeding, the underlying molecular mechanisms remain largely unknown. In study, we use a transcriptomics approach identify key genes regulatory networks affecting pollen maturation anthers response different day lengths. A total of 11,726 differentially expressed (DEGs) were revealed, which 177 at six time...
Acanthopanax senticosus extract (ASE), a dietary supplement with antifatigue, neuroprotective, and immunomodulatory properties, has been widely used due to its high polyphenol content. Our previous study showed that ASE could be treat Parkinson's disease (PD) as it contains multiple monoamine oxidase B inhibitors prescribed in early PD. However, mechanism remains ambiguous. In this study, we investigated the protective effects of on MPTP-induced PD mice explored underlying mechanisms action....
Wu-Mei-Wan (WMW) is a traditional Chinese herbal formulation that clinically prescribed to treat diabetes mellitus in China. WMW has been shown alleviate damage pancreatic β cells, but the underlying mechanism remains unclear. This study aims explore how plays protective role islets. Drug testing and analyses were performed on mice treated with three concentrations of (4800, 9600, 19,200 mg/kg/bw) for four consecutive weeks. Blood was collected from both db/db wild-type determine fasting...
Celastrol, a natural triterpene, has been shown to treat obesity and its related metabolic disorders. In this study, we first assessed the relationship between antiobesity effects of celastrol antiinflammatory activities. Our results showed that can reduce weight gain, ameliorate glucose intolerance, insulin resistance, dyslipidemia without affecting food intake in high‐fat diet‐induced obese mice. A CLAMS was used clarify improvement profiles attribute increased adipose thermogenesis after...