A5101735573- Lubricants and Their Additives
- Tribology and Wear Analysis
- Aquaculture disease management and microbiota
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Diamond and Carbon-based Materials Research
- Sulfur Compounds in Biology
- Circular RNAs in diseases
- Force Microscopy Techniques and Applications
- Pleural and Pulmonary Diseases
- Ionic liquids properties and applications
- Molecular Sensors and Ion Detection
- RNA modifications and cancer
- Tuberculosis Research and Epidemiology
- Immune Cell Function and Interaction
- Reinforcement Learning in Robotics
- Cancer-related gene regulation
- Aquaculture Nutrition and Growth
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Software-Defined Networks and 5G
- Immune Response and Inflammation
- Advanced Bandit Algorithms Research
- Invertebrate Immune Response Mechanisms
- Bone health and treatments
Jiangxi Science and Technology Normal University
2022-2025
Henan Normal University
2017-2025
Xi’an Children’s Hospital
2025
Chinese Academy of Sciences
2013-2024
Dalian Medical University
2024
Lanzhou Institute of Chemical Physics
2013-2024
First Hospital of Shanxi Medical University
2022-2024
Shanxi Medical University
2022-2024
Beijing Institute of Technology
2024
Shanghai University of Traditional Chinese Medicine
2023-2024
Bacterial infection poses a significant challenge to wound healing and skin regeneration, leading substantial economic burdens on patients society. Therefore, it is crucial promptly explore develop effective methodologies for bacterial infections. Herein, we propose novel approach synthesizing nanostructures based antisense oligonucleotides (ASOs) through the coordination-driven self-assembly of Zn2+ with ASO molecules. This aims provide synergistic therapy chronic infections caused by...
Abstract Macroscale superlubricity is a prospective strategy in modern tribology to dramatically reduce friction and wear of mechanical equipment; however, it mainly studied for point-to-surface contact or special pairs experiments. In this study, robust macroscale point-to-point on steel interface was achieved the first time by using hydroxylated modified boron nitride nanosheets with proton-type ionic liquids (ILs) as additives ethylene glycol aqueous (EG aq ). The detailed process...
GSDME is the only direct executor of caspase-dependent pyroptosis in both canonical and non-canonical inflammasomes known to date fish, plays an important role anti-bacterial infection inflammatory response. In order determine regulation GSDMEa on antibacterial innate immune response, CcGSDMEa gene common carp ( Cyprinus carpio haematopterus ) was first identified characterized, then its function related defense investigated. Our results showed that expressions Cc at mRNA protein levels were...
The bile acid deoxycholic (DCA) is a known tumor promoter and it has been suggested that DCA-induced apoptosis plays an important role in colon development. In this study we have characterized the capacity of DCA to stimulate mitogen-activated protein kinase (MAPK) activity examined effect MAPK had on apoptosis. Analysis DCA-treated HCT116 cells using phosphorylation-specific antibodies vitro assays indicated both extracellular signal-regulated (ERK) p38 (p38), but not c-Jun N-terminal...
Conductive fibers are vital for next-generation wearable and implantable electronics. However, the mismatch of mechanical, electrical, biological properties between existing conductive human tissues significantly retards their further development. Here, concept neuro-like to meet these aforementioned requirements is proposed. A new wet spinning process established continuously produce pure gelatin hydrogel fibers. The key controllable rapid gelation solutions based on salting-out effect,...
Aeromonas veronii, hydrophila, Plesiomonas shigelloides, and Citrobacter freundii were opportunistic pathogen widely distributed in water environment fish population, causing diseases under stressful conditions. In this study, bacteria isolated from diseased common carp Cyprinus carpio with symptoms of hemorrhage on body surface, abdominal distention, flatulence the intestine. According to results biochemical characteristics, 16S rRNA sequencing analyses, isolates identified as A. P. C....
This work studies linear bandits under a new notion of gap-adjusted misspecification and is an extension Liu et al. (2023). When the underlying reward function not linear, existing usually relies on uniform parameter $\epsilon$ that measures sup-norm error best approximation. results in unavoidable regret whenever $\epsilon > 0$. We propose more natural model which only requires approximation at each input $x$ to be proportional suboptimality gap $x$. It captures intuition that, for...
It was found that the serine protease inhibitors BmSPI38 and BmSPI39 in silkworm can strongly inhibit activity of porcine pancreatic elastase, which has potential applicational value drug research development lung diseases, inflammatory skin aging caused by excessive release elastase. Previous studies have shown homotypic multimers obtained tandem expression significantly enhance antifungal structural homogeneity BmSPI39, while effect these two inhibitors, with different combinations, on...
Lung cancer, a commonly diagnosed malignancy, is the leading cause of cancer-related death worldwide. Aspirin suppresses progression and metastasis various cancers. However, effect aspirin on non-small cell lung cancer (NSCLC) has not been fully understood. It established that glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1) CD36 play vital role in lipid metabolism transport. This study aimed to clarify mechanism by which inhibits NSCLC proliferation via GPIHBP1. The blood...
Aeromonas veronii, hydrophila, Plesiomonas shigelloides, and Citrobacter freundii are opportunistic pathogens that widely distributed in aquatic environments fish populations, causing diseases under stressful conditions. In this study, bacteria were isolated from a group of diseased common carp, Cyprinus carpio, with symptoms hemorrhaging along the body surface, abdominal distention, flatulence intestine. According to results biochemical characteristics 16S rRNA sequencing analyses, isolates...
Introduction Initial immunotherapy outcomes with toripalimab suggest a potential paradigm shift in the treatment of advanced triple-negative breast cancer (TNBC), promising extended survival for patients. However, its cost-effectiveness TNBC within US health care context remains to be determined. Methods A 5-year Markov model was developed using data from TORCHLIGHT study evaluate plus nab-paclitaxel as first-line therapy metastatic or recurrent US. The incorporated efficacy and safety data,...
Bile acids, principally deoxycholic acid (DCA), have been implicated in the promotion of colon tumorigenesis both animals and humans. Increasing evidence suggests that bile acids may exert their tumor promoting activity by modulating intracellular signaling altering gene expression. In this study we investigated effect on suppressor p53 using human cell line HCT116, which retains wild-type functional response to DNA damage. We found exposure cells elevated concentrations DCA suppressed...
Th1 cell-mediated adaptive immune response is very important but may not be sufficient to control Mycobacterium tuberculosis (M. tuberculosis) infection. The roles of the various T cell subsets and cytokines in inflammatory processes are clearly elucidated. We investigated whether Th1, Th22 Th17 cells mediated cellular immunity at local site M. infection patients with tuberculous pleurisy (TBP). results showed that IFN-γ IL-22 IL-17 were elevated tubercular pleural fluid. Following...