A5100747881- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Orthodontics and Dentofacial Orthopedics
- Mesenchymal stem cell research
- Temporomandibular Joint Disorders
- Cleft Lip and Palate Research
- Periodontal Regeneration and Treatments
- dental development and anomalies
- Tracheal and airway disorders
- Cervical Cancer and HPV Research
- Tissue Engineering and Regenerative Medicine
- Gestational Trophoblastic Disease Studies
- Extracellular vesicles in disease
- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Craniofacial Disorders and Treatments
- RNA Interference and Gene Delivery
- Ovarian cancer diagnosis and treatment
- Muscle Physiology and Disorders
- Electrospun Nanofibers in Biomedical Applications
- MicroRNA in disease regulation
- Dysphagia Assessment and Management
- 3D Printing in Biomedical Research
- Cancer, Hypoxia, and Metabolism
- Advanced biosensing and bioanalysis techniques
Shanghai Stomatological Hospital
2017-2025
Fudan University
2017-2025
Westlake University
2024
Shandong First Medical University
2023-2024
Vanke (China)
2023-2024
Tsinghua University
2017-2024
Jiangxi University of Science and Technology
2023
Institute of Process Engineering
2023
Jilin Agricultural University
2021-2022
Office of Basic Energy Sciences
2022
Hydrogels are emerging as the most promising dressings due to their excellent biocompatibility, extracellular matrix mimicking structure, and drug loading ability. However, existing hydrogel exhibit limited breathability, poor environmental adaptability, potential resistance, options, which extremely restrict therapeutic effect working scenarios. Here, current research introduces first paradigm of textile based on novel gelatin glycerin (glyhydrogel) fibers fabricated by Hofmeister wet...
Monoamine neurotransmitters such as serotonin and dopamine are loaded by vesicular monoamine transporter 2 (VMAT2) into synaptic vesicles for storage subsequent release in neurons. Impaired VMAT2 function underlies various neuropsychiatric diseases. inhibitors reserpine tetrabenazine used to treat hypertension, movement disorders associated with Huntington's Disease Tardive Dyskinesia. Despite its physiological pharmacological significance, the structural basis underlying substrate...
Tissue hypoxia caused by upper airway collapse is a main cause of excessive oxidative stress and systemic inflammation in obstructive sleep apnea (OSA) patients. Increased reactive oxygen species (ROS) inflammatory responses affect cell survival ultimately contribute to tissue injury. In the present study, we proposed that induction ROS hypoxia, as an intrinsic stress, activates myoblast pyroptosis OSA. We found increased death abnormal expression markers skeletal muscle OSA mice. vitro...
Nonalcoholic fatty liver disease (NAFLD) is a metabolic that can eventually lead to cirrhosis and hepatocellular carcinoma. Porphyromonas gingivalis (P.g) the main pathogen causes periodontal disease, which participates in development of NAFLD. The purpose our study was further direct role P.g NAFLD underlying molecular mechanism. An animal model oral administration established, function pathology this were evaluated. gut microbiome products analysed. Furthermore, Th17/Treg balance spleen...
Abstract Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have emerged as an appealing alternative to cell therapy in regenerative medicine. Unlike bone marrow MSCs (BMSCs) cultured vitro with normoxia, vivo is exposed a hypoxic environment. To date, it remains unclear whether hypoxia preconditioning can improve the function of BMSC‐derived EVs and be more conducive repair. Herein, found that preconditioned BMSCs secrete biglycan (Bgn)‐rich via proteomics analysis,...
Abstract Carcinoma-associated fibroblasts (CAFs) are the main cellular components of tumor microenvironment and promote cancer progression by modifying extracellular matrix (ECM). The tumor-associated ECM is characterized collagen crosslinking catalyzed lysyl oxidase (LOX). Small vesicles (sEVs) mediate cell-cell communication. However, interactions between sEVs remain unclear. Here, we demonstrated that released from oral squamous cell carcinoma (OSCC)-derived CAFs induce crosslinking,...
Using l-histidine and cerium nitrate hexahydrate as raw materials, a green effective carbon dots (Ce,N-CDs) was prepared using hydrothermal synthesis their structures were confirmed by professional equipment. The anti-bacterial anti-corrosive behaviors of Ce,N-CDs systemically evaluated plate counting method electrochemical method, respectively. By analysis, the showed high bacterial inhibition efficiency for Escherichia coli (E. coli), which up to 94.27 %. Compared with N-doping (N-CDs),...
Gamma delta (γδ) T cells, a unique cell subgroup, are crucial in various immune responses and immunopathology
BACKGROUND:Curcumin has well-known, explicit biological anti-tumor properties. The Wnt/β-catenin signaling pathway plays a central role in tumor cell proliferation and curcumin can regulate the Wnt/b-catenin of several carcinomas. aim this study was to investigate impact on human gastric cancer cells. MATERIAL AND METHODS:We used 3 lines: SNU-1, SNU-5, AGS. Research methods were MTT assay, flow cytometry, clonogenic annexin V/PI method, Western blotting analysis, formation vivo TUNEL assay....
One of the fundamental questions in bone biology is where osteoblasts originate and how osteoblast differentiation regulated. The mechanism underlying which factors regulate chondrocyte to lineage commitment remains unknown. Our data showed that Runt-related transcription factor 1 (Runx1) expressed at different stages both differentiation. Runx1 chondrocyte-specific knockout (Runx1f/fCol2α1-cre) mice exhibited impaired cartilage formation, decreased density, an osteoporotic phenotype....
Periodontitis is initiated by serious and sustained bacterial infection ultimately results in chronic immune-mediated inflammation, tissue destruction, bone loss. The pathogenesis of periodontitis remains unclear. Host immunological responses to periodontal bacteria determine the severity mechanisms governing progression. This study aimed clarify effect hypoxia-inducible factor-1α (HIF-1α) activator dimethyloxalylglycine (DMOG) on a mouse model its underlying role macrophage polarization....
The aim of the present study was to obtain prevalence malocclusions in preschool children Shanghai, China. A cross-sectional survey conducted among 2335 aged 3–5 years from kindergartens. Several occlusal parameters were clinically assessed, including second deciduous molar terminal plane, canine relationship, degree overjet and overbite, anterior posterior crossbite, presence or absence physiologic spaces crowding. All parents subjects asked fill oral health knowledge questionnaires....
Conductive fibers are vital for next-generation wearable and implantable electronics. However, the mismatch of mechanical, electrical, biological properties between existing conductive human tissues significantly retards their further development. Here, concept neuro-like to meet these aforementioned requirements is proposed. A new wet spinning process established continuously produce pure gelatin hydrogel fibers. The key controllable rapid gelation solutions based on salting-out effect,...
Small extracellular vesicles (sEVs) are natural biocarriers for biomolecule transfer between cells and promising therapeutic strategies bone defect repair. In this study, human periodontal ligament stem cell (PDLSC)-derived sEVs (P-EVs) were immobilized in Matrigel to establish a topical cell-free transplantation strategy repair.PDLSCs cultured P-EVs isolated from the culture supernatant. rat bilateral calvarial model, P-EV/Matrigel was plugged into one PBS/Matrigel applied other. Bone...
Silk fibroin is regarded as a promising biomaterial in various areas, including bone tissue regeneration. Herein, Laponite® (LAP), which can promote osteogenic differentiation, was introduced into regenerated silk (RSF) to prepare an RSF/LAP hybrid hydrogel. This thixotropic hydrogel injectable during the operation process, favorable for repairing defects. Our previous work demonstrated that greatly promoted differentiation of osteoblasts vitro. In present study, found have excellent...