A5028555994- Spine and Intervertebral Disc Pathology
- Nitric Oxide and Endothelin Effects
- Mesenchymal stem cell research
- Spinal Fractures and Fixation Techniques
- Renin-Angiotensin System Studies
- Periodontal Regeneration and Treatments
- Tissue Engineering and Regenerative Medicine
- Wound Healing and Treatments
- Pelvic and Acetabular Injuries
- Photoreceptor and optogenetics research
- Toxin Mechanisms and Immunotoxins
- Neuroscience and Neural Engineering
- Neurogenesis and neuroplasticity mechanisms
- Cancer, Hypoxia, and Metabolism
- Microbial Inactivation Methods
- Tendon Structure and Treatment
- Advanced Sensor and Energy Harvesting Materials
- Heme Oxygenase-1 and Carbon Monoxide
- Cervical and Thoracic Myelopathy
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- MicroRNA in disease regulation
- Electrospun Nanofibers in Biomedical Applications
- Neonatal Health and Biochemistry
- Hemoglobin structure and function
- Ion Channels and Receptors
Shanghai Stomatological Hospital
2012-2024
Shandong Normal University
2009-2024
Jining University
2024
Fudan University
2011-2023
Tongji University
2019-2023
Shenzhen University
2021-2023
Shandong Provincial Hospital
2021-2023
Xijing University
2023
Shanghai Jiao Tong University
2023
Sun Yat-sen University
2021-2023
Hydrogels are emerging as the most promising dressings due to their excellent biocompatibility, extracellular matrix mimicking structure, and drug loading ability. However, existing hydrogel exhibit limited breathability, poor environmental adaptability, potential resistance, options, which extremely restrict therapeutic effect working scenarios. Here, current research introduces first paradigm of textile based on novel gelatin glycerin (glyhydrogel) fibers fabricated by Hofmeister wet...
Tissue hypoxia caused by upper airway collapse is a main cause of excessive oxidative stress and systemic inflammation in obstructive sleep apnea (OSA) patients. Increased reactive oxygen species (ROS) inflammatory responses affect cell survival ultimately contribute to tissue injury. In the present study, we proposed that induction ROS hypoxia, as an intrinsic stress, activates myoblast pyroptosis OSA. We found increased death abnormal expression markers skeletal muscle OSA mice. vitro...
Conductive fibers are vital for next-generation wearable and implantable electronics. However, the mismatch of mechanical, electrical, biological properties between existing conductive human tissues significantly retards their further development. Here, concept neuro-like to meet these aforementioned requirements is proposed. A new wet spinning process established continuously produce pure gelatin hydrogel fibers. The key controllable rapid gelation solutions based on salting-out effect,...
Treatment of cancer often involves uses multiple therapeutic strategies with different mechanisms action. In this study we investigated combinations nanosecond pulsed electric fields (nsPEF) low concentrations gemcitabine on human oral cells. Cells (Cal-27) were treated pulse parameters (20 pulses, 100 ns in duration, intensities 10, 30 and 60 kV/cm) then cultured medium 0.01 µg/ml gemcitabine. Proliferation, apoptosis/necrosis, invasion morphology those cells examined using MTT, flow...
Alveolar bone defects can arise as a consequence of trauma, infection, periodontal disease, or congenital alveolar fenestration. Many approaches have been employed in an effort to treat overcome such defects, but the ability effectively achieve regeneration remains elusive. Platelet-derived growth factor-BB (PDGF-BB) has shown serve key factor capable orchestrating cell proliferation, angiogenesis, and chemoattraction context osteogenic processes. Exactly how PDGF-BB affects human ligament...
Neural stem cells (NSCs) can generate new neurons to repair brain injury and central nervous system disease by promoting neural regeneration. MicroRNAs (miRNAs) involve in development, damage, neurological diseases repair. Recent reports show that several miRNAs express NSCs are important neurogenesis. Neurites play a key role NSC-related However, the mechanism of NSC neurite generation is rarely studied. We surprisingly noticed neurites increased after bone morphogenetic protein (BMP)...
Abstract Background Denis and Ferguson et al.’s three-column spinal theory has been widely accepted applied. However, this was proposed based solely on observation experience without thorough documented data analysis. The aim of study to analyze improve propose a novel concept in epidemiology, morphology biomechanics. Methods A retrospective analysis the computed tomography imaging patients with diagnosis T11-L5 vertebral fractures conducted between February 2010 December 2018....
Abstract Introduction The basis of orthodontic tooth movement (OTM) is the reconstruction periodontal tissue under stress. Increasing speed OTM has always been focus attention. Objectives Periodontal ligament stem cells (PDLSCs) are direct effector mechanical force, but mechanism by which PDLSCs sense stimuli unclear. Methods Human (hPDLSCs) were analyzed in presence or absence force loading with Flexcell system vitro. Then, tissues after stimulation vivo. In addition, a confined...
Objective: The immune compromised patients after treatment of oral cancer may have a chance infection by drug-resistant opportunistic microbes. We investigated the occurrence microorganisms in aged individuals receiving follow-up examinations China. Material and Methods: These were used as test group respective age grouped healthy control group. In this study, cavity such bacteria yeast taken for analysis. After screening representative microorganisms, their aptitude pervasiveness against...
Innate lymphoid cells (ILCs) are emerging as important players in inflammatory diseases. The oral mucosal barrier harbors all ILC subsets, but how these regulate the immune responses periodontal ligament tissue during periodontitis remains undefined. Here, we show that total ILCs markedly increased of patients compared with healthy controls. Among them, ILC1s and ILC3s, particularly NKp44 + ILC3 subset, predominant subsets accumulated ligament. Remarkably, ILC3s from produce more IL-17A...
Abstract Soluble guanylate cyclase (sGC) is a heme-containing metalloprotein in NO-sGC-cGMP signaling. NO binds to the heme of sGC catalyze synthesis second messenger cGMP, which plays critical role several physiological processes. However, molecular mechanism for mediate signaling remains unclear. Here fluorophore FlAsH-EDT 2 and fluorescent proteins were employed study NO-induced activation. labeling revealed that binding H-NOX domain increased distance between PAS separation coiled-coil...
Glutamate-induced excitotoxicity plays a critical role in the neurological impairment caused by middle cerebral artery occlusion. Achyranthes bidentata polypeptides have been shown to protect against functional damage occlusion, but underlying neuroprotective mechanisms and relationship glutamate-induced remain unclear. Therefore, current study, we investigated protective effects of cultured hippocampal neurons. Hippocampal neurons were treated with Mg2+-free extracellular solution...
Heterotopic ossification (HO) is a poorly characterized disease with ectopic bone formation in the musculoskeletal soft tissues.HO widely considered as tissue repair process goes away, endochondral to be major pathological basis.The molecular mechanism of how resident/recruited progenitor cells for regeneration error differentiated into chondrocytes remains unknown.Here, we found Transforming Growth Factor B Induced Gene Human Clone 3 (βig-h3) was highly expressed inflammation and...