A5114021798- Neuroscience and Neuropharmacology Research
- Cellular transport and secretion
- Genetic Neurodegenerative Diseases
- Mass Spectrometry Techniques and Applications
- Lysosomal Storage Disorders Research
- Heavy Metal Exposure and Toxicity
- Metabolism and Genetic Disorders
- Studies on Chitinases and Chitosanases
- Alcoholism and Thiamine Deficiency
- Biochemical Acid Research Studies
- Viral-associated cancers and disorders
- T-cell and Retrovirus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Lymphoma Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Cancer Research and Treatments
- Receptor Mechanisms and Signaling
- Lipid Membrane Structure and Behavior
- Pancreatic and Hepatic Oncology Research
- Genetics and Neurodevelopmental Disorders
- Trace Elements in Health
Fudan University
2023-2025
Shanghai Stomatological Hospital
2023-2024
Chinese PLA General Hospital
2022
Monoamine neurotransmitters such as serotonin and dopamine are loaded by vesicular monoamine transporter 2 (VMAT2) into synaptic vesicles for storage subsequent release in neurons. Impaired VMAT2 function underlies various neuropsychiatric diseases. inhibitors reserpine tetrabenazine used to treat hypertension, movement disorders associated with Huntington's Disease Tardive Dyskinesia. Despite its physiological pharmacological significance, the structural basis underlying substrate...
Abstract The secretion and quality control of glycosylphosphatidylinositol-anchored proteins (GPI-APs) necessitates post-attachment remodeling initiated by the evolutionarily conserved PGAP1, which deacylates inositol in nascent GPI-APs. Impairment PGAP1 activity leads to developmental diseases humans fatality infertility animals. Here, we present three structures (2.66−2.84 Å), revealing its 10-transmembrane architecture product-enzyme interaction details. holds GPI-AP acyl chains an...
Thiamine and pyridoxine are essential B vitamins that serve as enzymatic cofactors in energy metabolism, protein nucleic acid biosynthesis, neurotransmitter production. In humans, thiamine transporters SLC19A2 SLC19A3 primarily regulate cellular uptake of both vitamins. Genetic mutations these transporters, which cause deficiency, have been implicated severe neurometabolic diseases. Additionally, various prescribed medicines, including metformin fedratinib, manipulate complicating the...
Abstract Monoamine neurotransmitters such as serotonin and dopamine are loaded by vesicular monoamine transporter 2 (VMAT2) into synaptic vesicles for storage subsequent release in neurons. Impaired VMAT2 function underlies various neuropsychiatric diseases. inhibitors reserpine tetrabenazine used to treat hypertension, movement disorders associated with Huntington’s Disease Tardive Dyskinesia. Despite its physiological pharmacological significance, the structural basis underlying substrate...
Background: Positive circulating EBV-DNA is associated with a very poor outcome in Natural killer/T cell lymphoma (NKTCL). Efforts to further improve treatment of plasma EBV positive NKTCL are urgently needed. Aims: To investigate the clinical efficacy, load and safety P-GEMOXD combined anti-programmed death 1 (anti-PD-1) antibody Tislelizumab first-line NKTCL. Methods: In this prospective, single-arm, phase 2 trial, we recruited patients aged 18–70 years newly diagnosed who were Henan...