A5084644302- Advanced biosensing and bioanalysis techniques
- Lung Cancer Treatments and Mutations
- Gold and Silver Nanoparticles Synthesis and Applications
- Cytokine Signaling Pathways and Interactions
- Synthesis and biological activity
- RNA Interference and Gene Delivery
- Polyamine Metabolism and Applications
- ATP Synthase and ATPases Research
- Synthesis and Characterization of Pyrroles
- Cancer therapeutics and mechanisms
- Identification and Quantification in Food
- Click Chemistry and Applications
- Biosensors and Analytical Detection
- Melamine detection and toxicity
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced Biosensing Techniques and Applications
- Neuroblastoma Research and Treatments
- PI3K/AKT/mTOR signaling in cancer
Jiangxi Science and Technology Normal University
2024
State Key Laboratory of Food Science and Technology
2022-2023
Jiangnan University
2022-2023
Many patients with non-small cell lung cancer (NSCLC) initially benefit from epidermal growth factor receptor (EGFR) targeted therapy. Unfortunately, varying degrees of resistance or side effects eventually develop. Overcoming and preventing the EGFR inhibitors has become a hot topic research today. Based on previous studies AZD-9291, we designed synthesized two series 2,4-dichloro-6-methylpyrimidine derivatives, 19 compounds in total, as potential kinase. The most promising compound, L-18,...