A5029077688- Lung Cancer Treatments and Mutations
- Computational Drug Discovery Methods
- Nanoplatforms for cancer theranostics
- Cancer therapeutics and mechanisms
- Liver physiology and pathology
- Peptidase Inhibition and Analysis
- HER2/EGFR in Cancer Research
- Pancreatic and Hepatic Oncology Research
- Quinazolinone synthesis and applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Synthesis and biological activity
- Lung Cancer Research Studies
- Click Chemistry and Applications
- Neuroendocrine Tumor Research Advances
- Cancer Research and Treatments
- Advanced Nanomaterials in Catalysis
- Melanoma and MAPK Pathways
- Antimicrobial Peptides and Activities
- Cell Image Analysis Techniques
- PI3K/AKT/mTOR signaling in cancer
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Jiangxi University of Traditional Chinese Medicine
2020-2025
Jiangxi Provincial Cancer Hospital
2023-2025
China Pharmaceutical University
2018-2023
Jiangxi Science and Technology Normal University
2016-2018
Surgical resection constitutes the first choice of treatment for colorectal cancer (CRC). Despite advancements in intraoperative navigation, there remains a considerable lack effective targeting probes imaging-guided surgical navigation CRC owing to their high heterogeneity. Hence, developing suitable fluorescent probe detect specific types populations is crucial. Herein, we labeled ABT-510, small, CD36-targeting thrombospondin-1–mimetic peptide overexpressed various types, with fluorescein...
Despite therapeutic advances in glioma, glioma-related mortality rates remain high due to its extremely poor prognosis and recurrence. Near-infrared (NIR) fluorescence imaging technologies, using the clinically approved fluorescent probe 5-ALA, have gained prominence facilitating visualization of glioma resection. However, false-positive false-negative results 5-ALA decrease sensitivity specificity detecting thereby hampering use surgical navigation. Herein, a novel molecular MPA-Pip-abt-510...
Despite advancements in pancreatic cancer treatment, it remains one of the most lethal malignancies with extremely poor diagnosis and prognosis. Herein, we demonstrated efficiency a novel peptide GB-6 labeled near-infrared (NIR) fluorescent dye 3H-indolium, 2-[2-[2-[(2-carboxyethyl)thio]-3-[2-[1,3-dihydro-3,3-dimethyl-5-sulfo-1-(3-sulfopropyl)-2H-indol-2-ylidene]ethylidene]-1-cyclohexen-1-yl]ethenyl]-3,3-dimethyl-5-sulfo-1-(3-sulfopropyl)-, inner salt (MPA) radionuclide technetium-99m...
Acquired resistance to EGFR is a major impediment in lung cancer treatment, highlighting the urgent need discover novel compounds overcome drug resistance. In this study, we utilized silico methods and bioactivity evaluation for discovery identify active anticancer agents targeting
Many patients with non-small cell lung cancer (NSCLC) initially benefit from epidermal growth factor receptor (EGFR) targeted therapy. Unfortunately, varying degrees of resistance or side effects eventually develop. Overcoming and preventing the EGFR inhibitors has become a hot topic research today. Based on previous studies AZD-9291, we designed synthesized two series 2,4-dichloro-6-methylpyrimidine derivatives, 19 compounds in total, as potential kinase. The most promising compound, L-18,...
The designed novel peptide GB-6 with targeted GRPR-binding possesses more favorable pharmacokinetic properties and metabolic stability, as well superior tumor-targeting ability in pancreatic cancer models, relative to BBN<sub>7–14</sub>.
Hepatocellular carcinoma (HCC) is characterized by a high mortality and early diagnosis treatment are critically needed. Ang II type 1 receptor (AT1R) has recently emerged as potential molecular target for cancer intervention. Here, we labeled angiotensin (Ang II), an AT1R ligand that overexpressed in various solid cancers, with the near-infrared fluorescent dye, MPA, radionuclide technetium-99m, evaluated its capacity HCC detection. These analyses were done vitro using HepG2 (AT1R-positive)...
AbstractRecently, some studies have proven that AXL plays a crucial role in the drug resistance of tumors. At present, no inhibitors on market and it is essential to discover novel compounds targeting overcome resistance. In this work, based anchor structure, 21,313 were obtained by substructure search from more than 400,000 compounds. Then, Qvina Ledock selected for virtual screening obtain 17 Next, four (ARRY614, AMI-1, NG25, Butein) bioactivity evaluation after hydrogen bond cluster...
The designed novel targeting peptide GB-6 binding to GRPR possesses more favorable pharmacokinetic properties with lower intestinal activity as well superior tumor-targeting ability in colorectal cancer models than BBN<sub>7–14</sub>.
Despite recent advancements in colorectal cancer (CRC) treatment, the prognosis remains unfavorable primarily due to high recurrence and liver metastasis rates. Fluorescence molecular imaging technologies, combined with specific probes, have gained prominence facilitating real-time tumor resection guided by fluorescence. Hepatocyte growth factor (HGF) is overexpressed CRC, but advancement of HGF fluorescent probes has been impeded absence effective HGF-targeting small-molecular ligands....
Facing the significant challenge of overcoming drug resistance in cancer treatment, particularly caused by mutations epidermal growth factor receptor (EGFR), aim our study was to identify potent EGFR inhibitors effective against T790M/C797S/L858R mutant, a key player mechanisms. Our integrated silico approach harnessed machine learning, virtual screening, and activity evaluation techniques screen 5105 compounds from three libraries, aiming find candidates capable conferred T790M C797S within...
Highlights•Six series of quinazoline derivatives bearing semicarbazone moiety were designed and synthesized.•Most the selected compounds showed excellent cytotoxicity activity with IC50 values.•Compound 2 exhibits kinase inhibitory against EGFR WT T790M/L858R.•AO staining, cell cycle analysis docking study carried out.AbstractAimed at discovering effective inhibitors, six a designed, synthesized evaluated in different cancer lines (A549, HepG2, MCF-7 PC-3). Most remarkable values reaching...
Objectives: The objective of this study is to identify dual-target inhibitors against EGFR/c-Met through virtual screening, dynamic simulation, and biological activity evaluation. This endeavor aimed at overcoming the challenge drug resistance induced by L858R/T790M mutants. Methods: Active structures were gathered construct sets molecules. Next, property filtering was applied within compound library. compounds then identified screening cluster analysis. Subsequently, we conducted MTT...