A5100715357- Cardiomyopathy and Myosin Studies
- RNA modifications and cancer
- Cardiovascular Function and Risk Factors
- Viral Infections and Immunology Research
- Neurogenetic and Muscular Disorders Research
- Cardiovascular Effects of Exercise
- Atrial Fibrillation Management and Outcomes
- Congenital heart defects research
- Cardiac Arrhythmias and Treatments
- Congenital Anomalies and Fetal Surgery
- Cardiac pacing and defibrillation studies
- Receptor Mechanisms and Signaling
- Low-power high-performance VLSI design
- Cardiac electrophysiology and arrhythmias
- Radiation Effects in Electronics
- Genomics and Rare Diseases
- Acute Myocardial Infarction Research
- Neonatal and fetal brain pathology
- Hydrocarbon exploration and reservoir analysis
- Epilepsy research and treatment
- Mitochondrial Function and Pathology
- Synthesis and biological activity
- Cerebral Palsy and Movement Disorders
- Advanced Measurement and Detection Methods
- Analog and Mixed-Signal Circuit Design
Shanghai Municipal Human Resources and Social Security Bureau
2025
Chengdu Medical College
2014-2025
Sichuan University
2014-2025
West China Second University Hospital of Sichuan University
2014-2025
Ministry of Education of the People's Republic of China
2025
Boston Children's Hospital
2014-2023
Fudan University
2017-2023
Wuhan University of Technology
2022-2023
Zhongnan University of Economics and Law
2023
Zhongshan Hospital
2017-2023
Circulating platelets roll along exposed collagen at vessel injury sites and respond with filipodia protrusion, shape change, surface area expansion to facilitate platelet adhesion plug formation. Various glycoproteins were considered be both responders mediators of adhesion, yet the signaling kinetics emanating from these receptors do not fully account for rapid cytoskeletal changes that occur in blood flow. We found free N-terminal fragment G protein-coupled receptor (GPCR) GPR56 human...
Adhesion G protein-coupled receptors (aGPCRs) represent a distinct family of GPCRs that regulate several developmental and physiological processes. Most aGPCRs undergo GPCR autoproteolysis-inducing domain-mediated protein cleavage, which produces cryptic tethered agonist (termed Stachel (stinger)), cleavage-dependent -independent aGPCR signaling mechanisms have been described. G1 (ADGRG1 or receptor 56 (GPR56)) has pleiotropic functions in the development multiple organ systems, broad...
Polymerase chain reactions (PCR), thermally activated chemical which are widely used for nucleic acid amplification, have recently received much attention in microelectromechanical systems and micro total analysis because a wide variety of DNA/RNA molecules can be enriched by PCR further analyses. In the present work, droplet-based oscillating-flow chip was designed fabricated silicon microfabrication technique. Three different temperature zones, were stable at denaturation, extension...
Spinal muscular atrophy (SMA) is a progressive degenerative neuromuscular disease. Nusinersen, with its quick onset of action, can benefit patients early in the treatment course. However, there are currently no clinical studies regarding improvement motor function and nutritional status after loading period nusinersen. Here, we aimed to determine efficacy nusinersen improving children SMA treated Western China.In this retrospective study, data for all pediatric (aged < 18 years), genetically...
To evaluate the effectiveness and safety of nusinersen for treatment 5q-spinal muscular atrophy (SMA) among Chinese pediatric patients.
BACKGROUND Hypertrophic cardiomyopathy (HCM) is one of the most prevalent inherited myocardial disorders and characterized by considerable genetic phenotypic heterogeneity. A subset patients with HCM progress to a dilated phase (DPHCM), which associated poor prognosis; however, underlying pathogenesis remains inadequately understood. CASE SUMMARY In this study, we present case involving pedigree familial DPHCM conduct retrospective review identified gene mutations. Through panel sequencing...
Background: Supraventricular tachycardia (SVT) is very common in daily clinical practice, especially the emergency department, with rapid onset and urgent management. The review highlights recent genetic predispositions mechanisms SVT. Methods: Through analysis of epidemiology, familial clustering, gene mutations relevant literature，the elucidates properties potential pathophysiology Results: There are many pathophysiological related to atrioventricular node reentrant (AVNRT) (AVRT)....
ABSTRACT Introduction O'Donnell–Luria–Rodan (ODLURO) syndrome is an autosomal dominant disorder associated with KMT2E gene variants. ODLURO characterized mainly by developmental delay, intellectual disability and macrocephaly or microcephaly; in some patients, it may manifest as autism epilepsy. Methods Trio whole‐exome sequencing was performed on a female infant unexplained West regression. A de novo splicing variant the identified. The effects of this were analysed via minigene splice...
Abstract Background Nusinersen was the first approved disease modifying therapy (DMT) for spinal muscular atrophy (SMA). Intrathecal administration of nusinersen enables drug delivery directly to central nervous system, where motor neurons are located. Per package insert, individuals with SMA receive 4 loading doses followed by maintenance every months thereafter. The aim this analysis investigate practices and adherence in Chinese children SMA. Methods Data were analyzed from a...
Breeding productive tree genotypes is crucial for sustainable forestry, yet the hydraulic architecture along root-stem-leaf continuum that constrains biomass yield remains unclear. Here, six poplar hybrid with contrasting were used to quantify whole-plant resistance, its partitioning patterns, and anatomical traits continuum. We observed substantial genetic variations in resistance parameters. Roots contributed largest proportion of (> 54%). Components well-coordinated, all components was...
To explore and analyze the clinical characteristics of childhood functional neurological disorder (FND) identify key factors influencing prognosis to optimize practice. In this retrospective study, data children with FND who visited Department Pediatric Neurology West China Second Hospital Sichuan University between March 2020 2023 were collected their prognosis. And 173 patients completed follow-up one year after diagnosis. Logistic regression was used associated Among 248 patients, a...
Bermond, Jackson and Jaeger [J. Combin. Theory Ser. B 35 (1983): 297-308] proved that every bridgeless ordinary graph $G$ has a circuit $4$-cover Fan 54 (1992): 113-122] showed $6$-cover which together implies $k$-cover for even integer $k\ge 4$. The only left case when $k = 2$ is the well-know double cover conjecture. For signed of graphs, it known $k\leq 5$, there are infinitely many coverable graphs without eulerian admit nowhere-zero $2$-flow but don't $1$-cover. conjectured $6$-cover....
Two series of novel sorafenib analogs containing a sulfonylurea unit were synthesized and their chemical structures confirmed by 1H-NMR, 13C-NMR, MS spectrum elemental analysis. The compounds evaluated for the cytotoxicity against A549, Hela, MCF-7, PC-3 cancer cell lines. Some showed moderate cytotoxic activity, especially 1-(2,4-difluorophenylsulfonyl)-3-(4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea (6c) 1-(4-bromophenylsulfonyl)-3-(4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea...
Recent studies in septic models have shown that myocardial calpain activity and TNF-α expression increase during sepsis inhibition of activation downregulates improves cardiac dysfunction. However, the mechanism underlying this pathological process is unclear. Thus, present study, we aimed to explore whether IκBα/NF-κB signaling linked mice. Adult male mice were injected with LPS (4 mg/kg ip) induce sepsis. Myocardial activity, assessed, function was evaluated using Langendorff system. In...
Atrial fibrillation (AF) is the most common cardiac arrhythmia among older patients (≥ 80 years) in clinical practice. The index of neutrophil percentage-to-albumin ratio (NPAR) a reliable predictor adverse outcomes cardiovascular diseases. There scarce evidence regarding association between NPAR and mortality with AF.The research was conducted 1141 AF January 2015 June 2020, hospitalized at Huadong Hospital affiliated Fudan University. primary outcome were 28-day all-cause mortality. Cox...