A5101947402- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Fluoride Effects and Removal
- Tropical and Extratropical Cyclones Research
- Ocean Waves and Remote Sensing
- Ship Hydrodynamics and Maneuverability
- RNA and protein synthesis mechanisms
- Arsenic contamination and mitigation
- Cardiovascular Disease and Adiposity
- Spinal Cord Injury Research
- Ovarian cancer diagnosis and treatment
- Advanced Statistical Process Monitoring
- Genetic diversity and population structure
- Inclusion and Disability in Education and Sport
- IL-33, ST2, and ILC Pathways
- Cerebral Palsy and Movement Disorders
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Meat and Animal Product Quality
- Genomics and Rare Diseases
- Nutritional Studies and Diet
- Genetics and Neurodevelopmental Disorders
- Genetic Associations and Epidemiology
Shanghai Jiao Tong University
2016-2025
Cipher Gene (China)
2025
Sichuan University
2025
China Medical University
2024
Collaborative Innovation Centre for Advanced Ship and Deep-Sea Exploration
2019
Shanghai Veterinary Research Institute
2018
Shenzhen Center for Disease Control and Prevention
2011-2013
Abstract Platinum-based chemotherapy remains one of the major choices for treatment ovarian cancer (OC). However, primary or acquired drug resistance severely impairs their efficiency, thereby causing failure and poor prognosis. SH3 domain containing ring finger 2 (SH3RF2) has been linked to development cancer. Here we find higher levels SH3RF2 in tumor tissues from cisplatin-resistant OC patients when compared those cisplatin-sensitive patients. Similarly, cells also express than normal...
Adherence to the healthy eating index-2020 before and after diagnosis is associated with better overall survival in patients ovarian cancer.
Control charts are widely used to detect process variations that can reveal out-of-control events. Among various methods in the literature, spectral control popular for monitoring processes with periodic behavior. Yet, highly noisy environments, their performance may become unsatisfactory, because they designed on features (e.g., periodogram), which could be easily masked by strong noise. Moreover, would incorrectly report many correlated-but-not-periodic signals as ones, leading a high...
ABSTRACT Introduction O'Donnell–Luria–Rodan (ODLURO) syndrome is an autosomal dominant disorder associated with KMT2E gene variants. ODLURO characterized mainly by developmental delay, intellectual disability and macrocephaly or microcephaly; in some patients, it may manifest as autism epilepsy. Methods Trio whole‐exome sequencing was performed on a female infant unexplained West regression. A de novo splicing variant the identified. The effects of this were analysed via minigene splice...
Abstract The differences in artificial and natural selection have been some of the factors contributing to phenotypic diversity between Chinese western pigs. Here, 830 individuals from pig breeds were genotyped using reduced-representation genotyping method. First, we identified signatures for different breeds. By comparing pigs along first principal component, growth gene IGF1R ; immune genes IL1R1 , IL1RL1 DUSP10 RAC3 SWAP70 meat quality-related SNORA50 olfactory OR1F1 as candidate...
Summary Inbreeding, which has several causes including genetic drift, population bottlenecks, mating of close relatives and selection, can leave tracts runs homozygosity ( ROH ) along genomes. Recently, decreasing performance on reproductive traits, might have resulted from inbreeding, been observed in Chinese pigs. In this study, 830 individuals Western pig breeds were genotyped using the reduced‐representation sequencing method. After imputation quality control, 60 850 high‐confidence SNP...
Summary The Chinese Meishan pig breed is well known for its high prolificacy. Moreover, this can be divided into three types based on their body size: big Meishan, middle ( MMS ) and small SMS pigs. Few studies have reported the genetic signatures of pigs, particularly a genome‐wide scale. Exploring could quite valuable revealing architecture phenotypic variation. Thus, we performed research in two parts genome reducing sequencing data 143 pigs (74 69 pigs). First, detected selection among...
Chinese indigenous pigs in Zhejiang Province are well known for their high fecundity. In order to verify breed subdivision at the genomic level, we investigated genetic diversity and population structure of seven breeds made comparisons with three Western pig using next-generation sequencing data. Parameters obtained from allelic richness proportion polymorphic markers indicated that was higher than pigs, highest lowest values found Chaluand Landrace respectively. Both neighbor-joining tree...
The relationship between growth and immune phenotypes has been presented in the context of physiology energy allocation theory, but rarely explained genetically humans. As more summary statistics genome-wide association studies (GWAS) become available, it is increasingly possible to explore genetic traits at level statistics. In this study, publicly available related were used evaluate correlation coefficients traits, as well cause effect them. addition, pleiotropic variants KEGG pathways...
Pudong White (PW) pigs are distributed in the Taihu region of China and characterized by their completely white coats. A heated debate concerning this genetic resource its relationship to western pig breeds has arisen, due coat animals. To determine whether PW is a unique resource, we performed detailed assessment relationships among PW, six from population three breeds, based on whole-genome single nucleotide polymorphism (SNP) data. total 68 102 SNPs were identified genomes tested...
Objective Porcine respiratory disease is one of the most important health problems causing significant economic losses. To understand genetic basis for susceptibility to swine enzootic pneumonia (EP) in pigs, we detected 102,809 single nucleotide polymorphisms a total 249 individuals based on genome-wide sequencing data. Methods Genome comparison EP three pig breeds (Jinhua, Erhualian, and Meishan) with two western lines that are considered more resistant (Duroc Landrace) using...
In this study, we investigated the genetic variants, including SNPs and indels (short insertions or deletions, less than 50 bp in length), genomes structures of five pig populations (in northern Taihu Lake region, Jiangsu Province) using genotyping by genome reducing sequencing (GGRS) approach. A total 581 million good reads with an average depth 11× coverage 2.16% were used to call variants. general, 202 106 34 415 obtained, which 2690 224 capable inducing protein-coding changes. The genes...