A5025160662- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Mechanisms of cancer metastasis
- Circadian rhythm and melatonin
- Signaling Pathways in Disease
- Enzyme Structure and Function
- Neuroscience and Neuropharmacology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Blood properties and coagulation
- Apelin-related biomedical research
- Glycosylation and Glycoproteins Research
- Ion channel regulation and function
- Cell Adhesion Molecules Research
- CAR-T cell therapy research
- Cardiac electrophysiology and arrhythmias
- Axon Guidance and Neuronal Signaling
- Photoreceptor and optogenetics research
- Protein Kinase Regulation and GTPase Signaling
- Fibroblast Growth Factor Research
- Protein Structure and Dynamics
- Monoclonal and Polyclonal Antibodies Research
- Genetics, Aging, and Longevity in Model Organisms
- Cellular transport and secretion
- ATP Synthase and ATPases Research
University of Chicago
2014-2020
University of Chicago Medical Center
2014
Adhesion G protein-coupled receptors (aGPCRs) play critical roles in diverse biological processes, including neurodevelopment and cancer progression. aGPCRs are characterized by large extracellular regions (ECRs) that autoproteolytically cleaved from their membrane-embedded signaling domains. Although ECRs regulate receptor function, it is not clear whether a direct regulatory role G-protein or simply serve as protective cap for the activating "
Adhesion G-protein-coupled receptors (aGPCRs) play critical roles in diverse cellular processes neurobiology, development, immunity, and numerous diseases. The lack of molecular understanding their activation mechanisms, especially with regard to the transmembrane domains, hampers further studies facilitate aGPCR-targeted drug development. Latrophilin-1/ADGRL1 is a model aGPCR that regulates synapse formation embryogenesis, its mutations are associated cancer attention-deficit/hyperactivity...
Determining macromolecular structures from X-ray data with resolution worse than 3 Å remains a challenge. Even if related starting model is available, its incompleteness or bias together low observation-to-parameter ratio can render the process unsuccessful very time-consuming. Yet, many biologically important macromolecules, especially large assemblies, membrane proteins and receptors, tend to provide crystals that diffract resolution. A new algorithm tackle this problem presented uses...
Abstract Blocking the interaction between cell-surface receptors and their ligands is a proven therapeutic strategy. Adhesion G protein-coupled (aGPCRs) are key that regulate numerous pathophysiological processes, large extracellular regions (ECRs) mediate ligand binding function. The aGPCR GPR56/ADGRG1 regulates central nervous system myelination melanoma progression by interacting with its ligand, tissue transglutaminase 2 (TG2), but molecular basis for this largely undefined. Here, we...
Adhesion G‐protein coupled receptors (aGPCRs) contain uniquely large, autoproteolyzed extracellular regions that are involved in cell adhesion and may couple cellular to receptor signaling. The latrophilin (Lphn/ADGRL) family of aGPCRs has important roles brain development, such as mediating interactions with fibronectin leucine‐rich repeat transmembrane proteins (FLRTs) order form synaptic junctions. There is growing interest Lphns promising drug targets because mutations associated...