A5013250427- Cancer therapeutics and mechanisms
- Quinazolinone synthesis and applications
- Synthesis and biological activity
- PI3K/AKT/mTOR signaling in cancer
- Liver physiology and pathology
- Immune Response and Inflammation
- Biochemical and Molecular Research
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- NF-κB Signaling Pathways
- Chemical Synthesis and Analysis
- Synthesis and Biological Evaluation
- Synthesis of heterocyclic compounds
- Click Chemistry and Applications
- Microbial bioremediation and biosurfactants
- Synthesis and pharmacology of benzodiazepine derivatives
- HER2/EGFR in Cancer Research
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Synthesis and Characterization of Heterocyclic Compounds
- Inflammation biomarkers and pathways
- RNA Research and Splicing
- Monoclonal and Polyclonal Antibodies Research
- Enzyme function and inhibition
- Microbial Community Ecology and Physiology
Wenzhou Medical University
2020-2025
University of Chinese Academy of Sciences
2022-2025
Yanbian University
2025
Jinan University
2024
Guangdong Provincial People's Hospital
2024
First Affiliated Hospital of Wenzhou Medical University
2024
Jiangxi Science and Technology Normal University
2015-2023
Wenzhou University
2022
Zhejiang Lab
2022
Dalian University of Technology
2020-2021
Discovering effective anti-inflammatory drugs and targets is a critical research priority. Herein, 28 novel phenylamide derivatives were designed synthesized. Compound D9 showed favorable activities in acute lung injury (ALI) sepsis mouse models. The target of was predicted studied, c-Kit identified by surface plasmon resonance (SPR) cellular thermal shift assay (CETSA), which demonstrated high selectivity kinase activity profiling. It further verified that participated the LPS-induced...
Myeloid differentiation primary response protein 88 (MyD88) is crucial to immune cascades mediated by Toll-like receptors (TLRs) and interleukin-1 (IL-1Rs). MyD88 dysregulation has been linked a wide variety of inflammatory diseases, making it promising new target for anti-inflammatory cancer therapy development. In this study, 46 compounds were designed synthesized inspired virtual screen hit. The activity was evaluated biologically, c17 discovered have high binding affinity with MyD88. It...
Acute lung injury (ALI) and sepsis are both serious complex conditions associated with high mortality, yet there no effective treatments. Herein, we designed synthesized a series of diphenyl 6-oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide analogues exhibiting anti-inflammatory activity. The optimal compound J27 decreased the release TNF-α IL-6 in mouse human cells J774A.1 THP-1 (IL-6 IC50 = 0.22 μM) through NF-κB/MAPK pathway. demonstrated remarkable protection against ALI vivo...
Two series of novel sorafenib analogs containing a sulfonylurea unit were synthesized and their chemical structures confirmed by 1H-NMR, 13C-NMR, MS spectrum elemental analysis. The compounds evaluated for the cytotoxicity against A549, Hela, MCF-7, PC-3 cancer cell lines. Some showed moderate cytotoxic activity, especially 1-(2,4-difluorophenylsulfonyl)-3-(4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea (6c) 1-(4-bromophenylsulfonyl)-3-(4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea...
UC and ALI are inflammatory diseases with limited treatment in the clinic. Herein, fragment-based anti-inflammatory agent designs were carried out deriving from cyclohexylamine/cyclobutylamine several fragments agents our lab. AF-45 (IC50 = 0.53/0.60 μM on IL-6/TNF-α THP-1 macrophages) was identified as optimal molecule using ELISA MTT assays 33 synthesized compounds. Through mechanistic studies a systematic target search process, found to block NF-κB/MAPK pathway IRAK4, promising for...
Abstract BACKGROUND Petroleum hydrocarbon pollution has become a global concern, and seeking an appropriate strategy for treatment of petroleum hydrocarbons is necessary, especially under saline–alkaline conditions. In this study, microbial consortia capable utilizing low‐molecular‐weight aliphatic ( n ‐decane, ‐dodecane ‐hexadecane) as the sole carbon source were enriched from crude‐oil‐contaminated soils, their community profiles evaluated using high‐throughput sequencing 16S rRNA gene....