A5046974147- Chemical synthesis and pharmacological studies
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Synthesis and Reactions of Organic Compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Immune Response and Inflammation
- Venous Thromboembolism Diagnosis and Management
- Neurological Disorders and Treatments
- Intramuscular injections and effects
- Cardiac Ischemia and Reperfusion
- Phytochemicals and Antioxidant Activities
- Inflammasome and immune disorders
- X-ray Diffraction in Crystallography
- COVID-19 Clinical Research Studies
- Free Radicals and Antioxidants
- Organic Chemistry Cycloaddition Reactions
- Synthesis and Biological Evaluation
- Ultrasound and Hyperthermia Applications
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Chemistry and Chemical Engineering
- Eicosanoids and Hypertension Pharmacology
- Infrared Thermography in Medicine
- Crystallization and Solubility Studies
- Medicinal plant effects and applications
Bashkir State Medical University
2014-2025
Ministry of Health of the Russian Federation
2020-2024
Kazan Federal University
2022
Background: Hormone signaling plays a significant role in cancerogenesis. This review presents comprehensive analysis of FDA-approved drugs, as well recent clinical trials drugs acting on hormone pathways. It discusses traditional methods hormonal cancer therapy and identifies new mechanisms signaling. The has made use the databases Clinicaltrials.gov PubMed to find trends development anti-cancer related hormonal-dependent breast cancer. Methods: A search Drugs@FDA database was conducted...
Kaempferia rhizome is a famous traditional herbal medical in tropical and subtropical areas. Kaempferol (KPF) one of the main bioactive compounds rhizome, with anti-oxidant/anti-inflammatory effects demonstrated various disease models, including cancers, obesity diabetes. Inflammation plays an important role pathogenesis diabetic nephropathy (DN). TRAF6 functions as signal transducer toll-like receptor 4 NF-κB pro-inflammatory signaling pathway. We aimed at investigate whether KPF able to...
Objective: Low fetal resistance to hypoxia is a factor in stillbirth and neonatal encephalopathy. This review examines movement patterns response as predictor of the likelihood stillbirth. Monitoring dynamics movements during maternal apnea could allow assessment hypoxia. The goal this study describe practical application method by doctors pregnant women. Mechanism: We searched relevant keywords international scientific literature databases Scopus Web Science, well for patents granted China,...
Obesity has been recognized as a major risk factor for the development of chronic cardiomyopathy, which is associated with increased cardiac inflammation, fibrosis, and apoptosis. We previously developed an anti-inflammatory compound C66, prevented inflammatory diabetic complications via targeting JNK. In present study, we have tested hypothesis that C66 could prevent obesity-induced cardiomyopathy by suppressing JNK-mediated inflammation. High-fat diet (HFD)-induced obesity mouse model...
A protocol for the preparation of 7-amido indoles via regioselective C–H bond functionalization has been first accomplished under Ru(II) catalysis. Indole derivatives and 4-aryl/heteroaryl/benzyl/alkyl dioxzaolines containing various substituents were applicable this transformation, readily providing amidated in moderate to good yields. This novel process many advantages, including compatibility with diverse functional groups, broad substrate scopes, mild reaction conditions. Deuteration...
Introduction. Among the various animal models of depression used to study pathogenesis and evaluate antidepressant action new compounds, based on social stress are characterized by high constructive, face predictive validity. The rat model repeated defeats allows induce a depressive-like state corresponding in humans effect substances with activity. Aim. To 3-ethoxythietane-1,1-dioxide (3ETD) rats using resident-intruder paradigm. Materials methods. White outbred male weighing 200–250 g...
The development of new drugs derived from plant sources is significant interest in modern pharmacy. One the promising for introduction into pharmaceuticals Tripleurospermum inodorum (L.) Sch. Bip., also known as perforatum (Merat.) M. This has been shown to possess various biological activities, including anti-inflammatory, antimicrobial, and antimycotic among others. However, a review current literature reveals paucity studies investigating chemical composition herb Bip. study presents...
Introduction — Magnetic resonance imaging-guided focused ultrasound (MRgFUS) is used for ablation of various solid tumors and treatment neurological diseases. During ablation, brain tissue injured, resulting in the formation necrosis edema zones. Therefore, strategies to minimize damage are highly relevant. The goal our research was study neuroprotective effect remote ischemic preconditioning (RIPC) movement disorders using MRgFUS. Material Methods design blinded randomized controlled...
Introduction. The use of synthetic drugs is associated with a number side effects. When choosing therapy to correct symptoms and treat dental diseases such as stomatitis, periodontitis, gingivitis, cheilitis, it preferable herbal medicines in combination traditional therapy, which would improve the resistance periodontal tissues pathogenic microorganisms. Herbal preparations are highly effective well tolerated, allows them be used modern medicine. Aim. To develop medicinal collection...
Introduction. In pathological practice, one of the primary histochemical methods for detecting early ischemic damage to cardiomyocytes is staining with hematoxylin-basic fuchsin-picric acid (HBFP), commonly known as Lie method. HBFP results in red-brown sarcoplasm due basic fuchsin, while intact myocytes appear yellow picric acid. However, critical evaluations have raised concerns about using method postmortem diagnosis. Therefore, improve diagnosis damage, it appears reasonable supplement...
Suffocation syndrome is the leading cause of hypoxia and mortality in most common lung diseases, asthma COVID-19. Inhaled corticosteroids (ICSs) have been shown to be main-stay critical care these diseases. Meanwhile, from strangulated highest low-income countries because ICSs are not currently available many patients. Warm alkaline hydrogen peroxide solutions (WAHPSs) reportedly invented recent years urgently turn thick sputum, mucus, pus, serous fluid, blood clots other biological masses...
Pyolytics are drugs that dissolve thick pus when applied topically. This group of was discovered in early 21st century Russia as a result successful repurposing antiseptics hydrogen peroxide, sodium bicarbonate and chloride from to pyolytics. Prior this watershed event pharmacy, the problem effective treatment purulent diseases had not been solved. The fact is before various mainly disinfectants solutions were used, which hypertonic solution 3 - 6% peroxide took leading role "antipurulent"...
Introduction. A review of the scientific literature showed that current standards for assessing quality drugs does not include an assessment osmotic activity drug solutions and their local irritant effect on tissues at sites subcutaneous, intramuscular intravenous injections. Therefore, currently injectable considered to be high may have isotonic postinjection safety. Text. study concentration range ready injection acceptable value main ingredients is in 0.01 76 %. Direct measurement with...
The local action of hydrogen peroxide solutions on such dense biological masses, as pus, mucus, sputum, and blood clots, is influenced not only by the concentration but also alkalinity solution temperature interaction medium. Increasing from 24C26C to 45C55C its pH 7.0 8.48.5 enhances pyolytic, mucolytic, hemolytic, bleaching, oxygen-releasing activity solutions. Simple heating achieves desired level hyperthermia, while addition sodium bicarbonate provides indicated alkalinity.
...
A series of new fluorinated 1-benzylisatins was synthesized in high yields via a simple one-pot procedure order to explore the possible effect ortho-fluoro (3a), chloro (3b), or bis-fluoro (3d) substitution on biological activity this pharmacophore. Furthermore, isatins could be converted into water-soluble isatin-3-hydrazones using their acid-catalyzed reaction with Girard's reagent P and its dimethyl analog. The cytotoxic action these substances is associated induction apoptosis caused by...
Injection of high-quality drugs can occasionally cause unexpected and unexplained local complications. As the current standard for drug quality control does not include an assessment irritation effects drugs, this effect may postinjection Simultaneously, be assessed based on tissue inflammation. The dynamics temperature assess Infrared monitoring skin at subcutaneous, intramuscular, intravenous injection sites under experimental clinical conditions improve their safety. Therefore, there is a...
Natural monoterpenes and their derivatives are widely considered as effective ingredients for the design production of new biologically active compounds with high antioxidant, antimicrobial anti-protozoa properties. In this study, we synthesized two series thiotherpenoids "sulfide-sulfoxide-sulfone", different bicyclic monoterpene skeleton (bornane pinane) structures. The effect obtained on platelet aggregation was investigated by using molecular docking technique. data revealed that all may...