A5047716489- Synthesis and biological activity
- Quinazolinone synthesis and applications
- Cancer therapeutics and mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- HIV/AIDS drug development and treatment
- Liver physiology and pathology
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Cancer Mechanisms and Therapy
- Synthesis and Reactivity of Heterocycles
- PI3K/AKT/mTOR signaling in cancer
- Irrigation Practices and Water Management
- Drug Transport and Resistance Mechanisms
- Synthesis of heterocyclic compounds
- Lung Cancer Treatments and Mutations
- Bioactive Compounds and Antitumor Agents
- Protein Degradation and Inhibitors
- Synthesis and Reactions of Organic Compounds
- Chemical Synthesis and Analysis
- Plant Physiology and Cultivation Studies
- Synthetic Organic Chemistry Methods
- Multicomponent Synthesis of Heterocycles
- Histone Deacetylase Inhibitors Research
Shenyang Pharmaceutical University
2016-2025
Jilin University
2025
Xinjiang Production and Construction Corps
2017-2024
Shihezi University
2008-2024
Xinjiang Academy of Animal Science
2024
Animal Science Research Institute
2024
Guangzhou University of Chinese Medicine
2024
Changchun University of Science and Technology
2015-2024
Xuzhou Medical College
2024
Institute of Physics
2024
Tumor necrosis factor (TNF)-alpha is a key mediator of sepsis-associated multiorgan failure, including the acute respiratory distress syndrome. We examined role protein tyrosine phosphorylation in TNF-alpha-induced pulmonary vascular permeability. Postconfluent human lung microvascular and artery endothelial cell (EC) monolayers exposed to recombinant TNF-alpha displayed dose- time-dependent increase transendothelial [(14)C]albumin flux absence EC injury. also increased proteins, several...
Inhibition of the programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) interaction using small-molecule inhibitors is an emerging immunotherapeutic approach. A novel series [1,2,4]triazolo[4,3-a]pyridines were designed and found to be potent PD-1/PD-L1 interaction. Among them, compound A22 exhibited most activity, as assessed by homogenous time-resolved fluorescence assay, with IC50 92.3 nM. Furthermore, dose-dependent elevated interferon-γ production in a co-culture model...
A series of novel 1-anilino-4-(arylsulfanylmethyl)phthalazines were designed and synthesized. The structures all the compounds confirmed by IR, 1H-NMR, elemental analysis MS. analogues 1-(3-chloro-4-fluoroanilino)-4-(3,4- difluorophenylthio-methyl)phthalazine (12) 1-(4-fluoro-3-trifluoromethylanilino)-4- (3,4-difluorophenyl-thiomethyl)phthalazine (13) showed higher activity than a cisplatin control when tested in vitro against two different cancer cell lines using microculture tetrazolium...
Proteolytic processing of amyloid precursor protein (APP) by β- and γ-secretases generates β-amyloid (Aβ) peptides, which accumulate in the brains individuals affected Alzheimer disease. Detergent-resistant membrane microdomains (DRM) rich cholesterol sphingolipid, termed lipid rafts, have been implicated Aβ production. Previously, we others reported that four integral subunits γ-secretase associate with DRM. In this study investigated mechanisms underlying DRM association subunits. We...
A series of novel pyrazolo[1,5-a]pyrimidines were designed and synthesized in order to find potent anti-tumor compounds. The structures all the compounds confirmed by IR, (1)H-NMR, elemental analysis, MS. Their activities against cancer cell lines tested MTT method vitro. Compound 19 displayed activity.
A series of novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives has been designed and synthesized in order to find anti-tumor compounds. The structures all the compounds were confirmed by IR, 1H-NMR, MS elemental analysis. Their activities against cancer cell lines (HT-1080 Bel-7402) tested MTT method vitro. Among them, compound 19 displayed best activity with IC50 values 12.3 μM 6.1 Bel-7402 HT-1080 respectively.