A5100319123- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Chemical Synthesis and Analysis
- RNA modifications and cancer
- Antibiotic Resistance in Bacteria
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Click Chemistry and Applications
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Metabolomics and Mass Spectrometry Studies
- Cancer therapeutics and mechanisms
- Insect Resistance and Genetics
- Biochemical and Molecular Research
- Hippo pathway signaling and YAP/TAZ
- Signaling Pathways in Disease
- Ocular Surface and Contact Lens
- Monoclonal and Polyclonal Antibodies Research
- Traditional Chinese Medicine Analysis
- Plant Virus Research Studies
- Inflammatory mediators and NSAID effects
- Cancer Genomics and Diagnostics
- NF-κB Signaling Pathways
- Plant-based Medicinal Research
Broad Institute
2021-2025
Shandong University of Traditional Chinese Medicine
2025
Shandong Academy of Sciences
2024-2025
Qilu University of Technology
2024-2025
Tongji Hospital
2020-2025
Huazhong University of Science and Technology
2020-2025
Liaocheng University
2025
Dalian Medical University
2018-2024
First Affiliated Hospital of Dalian Medical University
2024
Ningbo University
2023-2024
The hallmark of a molecular glue is its ability to induce cooperative protein–protein interactions, leading the formation ternary complex, despite weaker binding toward one or both individual proteins. Notably, extent cooperativity distinguishes glues from bifunctional compounds, which constitute second class inducers interactions. However, apart serendipitous discovery, there have been limited rational screening strategies for high exhibited by glues. Here, we propose binding-based screen...
ABSTRACT Gancao Fuzi decoction (GCFZT) is a traditional Chinese formula, which has been commonly used in clinical practice to treat inflammatory diseases. However, the active substance of GCFZT treatment inflammation not fully clarified. In this study, we orthogonal experiments design different formulations, resulting total 16 formulations. Subsequently, UPLC‐Q‐TOF‐MS/MS was analyze chemical composition and anti‐inflammatory activity differences these formulations were evaluated through an...
Abstract Colorectal cancer stem cells (CCSCs) play a critical role in mediating chemoresistance. Lactylation is post-translational modification induced by lactate that regulates gene expression. However, whether lactylation affects the chemoresistance of CCSCs remains unknown. Here, we demonstrate histone enhances CCSC both vitro and vivo. Furthermore, our findings showed p300 catalyzes H4 at K12, whereas HDAC1 facilitates its delactylation CCSCs. Notably, H4K12 (H4K12la) upregulates GCLC...
Muscle contraction and relaxation is regulated by transient elevations of myoplasmic Ca(2+). Ca(2+) released from stores in the lumen sarco(endo)plasmic reticulum (SER) to initiate formation activation a class release channels referred as ryanodine receptors (RyRs) pumped back into SER Ca(2+)-ATPases (SERCAs) terminate transient. Mutations type 1 receptor gene, RYR1, are associated with 2 skeletal muscle disorders, malignant hyperthermia (MH), central core disease (CCD). The evaluation...
Abstract Uneven oxygen supply in solid tumors leads to hypoxic and normoxic regions. Hypoxic cells exhibit increased secretion of lactate, which creates an acidic tumor microenvironment (TME). This TME is positively associated with metastasis. Despite the metastatic capacity cells, they are located relatively further away from blood vessels have limited access circulatory system. Studies shown that cancer stem (CSCs) enriched for metastasis-initiating generally undergo aerobic respiration,...
Diabetic nephropathy is one of the common microvascular complications diabetes. Iron death a recently reported way cell death. To explore effects iron on diabetic nephropathy, score was analyzed based network and pathway levels. Furthermore, markers related to were screened. Using RNA-seq data samples clustered uniformly disease classified. Differentially expressed gene analysis conducted typed samples, WGCNA algorithm used obtain key modules. String database perform protein interaction...
Scarlet fever is one of a variety diseases caused by group A Streptococcus (GAS). During 2011, scarlet epidemic characterized peak monthly incidence rates 2.9-6.7 times higher than those in 2006-2010 occurred Beijing, China. the epidemic, hospital-based enhanced surveillance for and pharyngitis was conducted to determine characteristics circulating GAS strains. The identified 3,359 clinical cases or pharyngitis. isolated from 647 patients; 76.4% strains were type emm12, 17.1% emm1. Almost...
The study aimed to investigate the state of human papillomavirus (HPV) infection in patients with cervical cancer Uyghur population China and identify miRNA as biomarker for HPV infection. We also performed genotyping determine variation types HPV. Using microRNA (miRNA) microarray technology, differential expression between HPV-infected uninfected normal tissues was determined; results were verified by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) using 20 samples...
To investigate whether curcumin regulates Notch signaling to cause neuroprotection and neurogenesis after focal ischemia reperfusion injury.Focal injury was modeled in rats by occluding the middle cerebral artery. These animals were given either (300 mg/kg) or corn oil (vehicle) intraperitoneal injection starting 1 h stroke continuing for 7 d. In parallel, sham-operated control received vehicle. All killed on day 12. The different treatment groups compared terms of neurobehavioral deficits,...
Both substance P and hypoxia-inducible factor 1 alpha (HIF-1α) are involved in inflammation angiogenesis. However, the relationship between HIF-1α rat periodontitis is still unknown.Ligation-induced was established to observe distribution expression of by immunohistochemistry. Rat gingival fibroblasts were cultured stimulated with Porphyromonas gingivalis lipopolysaccharide (LPS). Recombinant applied elaborate vitro. Primary mouse bone marrow-derived macrophages (BMMs) isolated effect on...