A5100456156- Nanoplatforms for cancer theranostics
- Nanocluster Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Carbon and Quantum Dots Applications
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Luminescence and Fluorescent Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Electrochemical sensors and biosensors
- Molecular Sensors and Ion Detection
- Photoacoustic and Ultrasonic Imaging
- Photodynamic Therapy Research Studies
- Extracellular vesicles in disease
- Crystallization and Solubility Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Immune cells in cancer
- X-ray Diffraction in Crystallography
- Advanced Photocatalysis Techniques
- Chemical Synthesis and Reactions
- Conducting polymers and applications
- Immunotherapy and Immune Responses
- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Sulfur Compounds in Biology
- Lanthanide and Transition Metal Complexes
Hong Kong University of Science and Technology
2024-2025
University of Hong Kong
2024-2025
Michigan Technological University
2024-2025
Ocean University of China
2023-2025
Hangzhou Normal University
2022-2024
Nanjing University
2014-2024
Central South University
2023-2024
Shanxi University
2015-2024
Gansu Provincial Hospital
2024
Shanxi University of Traditional Chinese Medicine
2014-2024
Ag2S quantum dots (QDs) emitting in the second near-infrared region (NIR-II, 1.0–1.4 μm) are demonstrated as a promising fluorescent probe with both bright photoluminescence and high biocompatibility for first time. Highly selective vitro targeting imaging of different cell lines achieved using biocompatible NIR-II QDs ligands. The cytotoxicity study illustrates negligible effects altering proliferation, triggering apoptosis necrosis, generating reactive oxygen species, causing DNA damage....
Shutting down glucose supply by oxidase (GOx) to starve tumors has been considered be an attractive strategy in cancerous starvation therapy. Nevertheless, the vivo applications of GOx-based therapy are severely restricted poor GOx delivery efficiency and self-limiting therapeutic effect. Herein, a biomimetic nanoreactor fabricated for starvation-activated cancer encapsulating prodrug tirapazamine (TPZ) erythrocyte membrane cloaked metal-organic framework (MOF) nanoparticle (TGZ@eM). The...
Abstract In this study, an organic semiconducting pro‐nanostimulant (OSPS) with a near‐infrared (NIR) photoactivatable immunotherapeutic action for synergetic cancer therapy is presented. OSPS comprises polymer nanoparticle (SPN) core and immunostimulant conjugated through singlet oxygen ( 1 O 2 ) cleavable linkers. Upon NIR laser irradiation, generates both heat to exert combinational phototherapy not only ablate tumors but also produce tumor‐associated antigens. More importantly,...
Abstract The fabrication of functional nanoplatforms for combating multidrug‐resistant bacteria is vital importance. Among them, silver nanoparticles (Ag NPs) have shown an antibacterial effect; however, the remainder cores Ag NPs after use might a toxic effect on humans. Thus, ions based materials been fabricated to substitute applications. Nevertheless, always‐on release state leads low biocompatibility, which limits their biomedical In addition, single also restricts ability. Herein,...
Abstract Development of real‐time non‐invasive imaging probes to assess infiltration and activation cytotoxic T cells (CTLs) is critical predict the efficacy cancer immunotherapy, which however remains challenging. Reported here an activatable semiconducting polymer nanoprobe (SPNP) for near‐infrared fluorescence (NIRF) photoacoustic (PA) a biomarker (granzyme B) associated with CTLs. SPNP comprises (SP) conjugated granzyme B cleavable dye‐labeled peptide as side chain, both emit NIRF PA...
Abstract The regulation of tumor immunosuppressive microenvironments via precise drug delivery is a promising strategy for preventing recurrence and metastasis. Inspired by the stealth strategy, stealthy nanovehicle based on neutrophil camouflage developed to achieve immunotherapy triggering pyroptosis. comprises anti‐CD11b‐ IR820‐conjugated bovine serum albumin nanoparticles loaded with decitabine. Camouflaged neutrophils, nanovehicles efficient hitchhiking owing biotropism neutrophils...
We first used oligomer polyamide resin as carbon source to prepare dots (CDs) that can emit white fluorescence via one step ultrasound at room temperature. have had a further understanding in the surface morphology and chemical characteristics of CDs by performing TEM, XPS, XRD, FT-IR, Raman spectroscopy. It has been found such good dispersion, low crystallinity, rich functional groups, easy large-scale production. The quantum yield fluorescent was enhanced from 3.3% 28.3% adding silane...
Abstract Reactive oxygen species (ROS) depletion and low ROS production that result from the intratumoral redox metabolism equilibrium energy conversion efficiency ultrasound mechanical to ROS‐represented chemical energy, respectively, are two vital inhibitory factors of sonodynamic therapy (SDT). To address concerns, a tumor metabolism‐engineered composite nanoplatform capable intervening metabolism, breaking equilibrium, reshaping microenvironment is constructed reinforce SDT against...
Nanoparticle-based radio-sensitizers can amplify the effects of radiation therapy on tumor tissue even at relatively low concentrations while reducing potential side to healthy surrounding tissues. In this study, we investigated a hybrid anisotropic nanostructure, composed gold (Au) and titanium dioxide (TiO2), as radio-sensitizer for triple-negative breast cancer (TNBC). contrast other gold-based radio sensitizers, dumbbell-like Au-TiO2 nanoparticles (DATs) show synergistic therapeutic...
Nowadays, efficient endo/lysosomal escape and the subsequent release of drugs into cytosol are major obstacles for nanoplatform-based cancer therapy. Herein, we first report a metal-organic framework-based nanoplatform (doxorubicin@ZIF-8@AS1411) intracellular environment-responsive enhanced In our system, was targeted toward cells. Then, it entrapped in endo/lysosomes, where pH-responsive decomposition occurred abundant Zn ions were released. The released could induce an influx counterions,...
A green approach to synthesise nitrogen/sulfur co-doped carbon dots has been developed and the product was successfully analysed by HPLC.
Controllable and visible delivery of therapeutic agents is critical for tumor precise therapy. Tumor targeting deep penetration are still challenging issues controllable delivery. Visible drug with imaging navigation can optimize the treatment window personalized medicine. Herein, a biomimetic platelet intelligent vehicle (IRDNP-PLT) was developed to achieve system, driving loading system. The platelets acted as engines repositories exert target functions. fluorescent photothermal agent...
Imaging to evaluate tumor-associated neutrophils (TANs) is imperative for cancer immunotherapy but remains challenging. We herein report an activatable semiconducting polymer nanoprobe (SPCy) near-infrared fluorescence (NIRF) and photoacoustic (PA) imaging of neutrophil elastase (NE), a biomarker TANs. SPCy comprises conjugated with hemicyanine (hemi-Cy) dye caged by NE-cleavable peptide as the side chain. After systemic administration, passively targets tumor reacts NE "uncage" hemi-Cy,...
Abstract Near‐infrared (NIR) chemiluminescence imaging holds potential for sensitive of cancer due to its low background; however, few NIR chemiluminophores are available, which share the drawback quantum yields (Φ CL ). Herein, we report synthesis and laparotomy. Molecular engineering electron‐withdrawing group at para‐position phenol‐dioxetane leads a highly bright chemiluminophore (DPT), showing Φ (4.6×10 −2 Einstein mol −1 ) that is 3 5‐fold higher than existing chemiluminophores. By...
Ionic liquid (IL)-loaded or metal ions-enriched nanoparticles have been witnessed to assist microwave ablation (MWA) and heighten heat utilization for tumor treatment, which, however, inevitably brings about cell dys-homeostasis severely endangers normal cells tissues. In this report, a nonionic MWA sensitizer that encapsulates ethyl formate (EF) doxorubicin (DOX) in liposomes (EF-DOX-Lips) was constructed reinforce combined therapy against incomplete MWA-induced recurrence. EF EF-DOX-Lips...