A5086815085- Pharmacological Effects of Natural Compounds
- Rheumatoid Arthritis Research and Therapies
- Cancer-related molecular mechanisms research
- Natural Compounds in Disease Treatment
- MicroRNA in disease regulation
- Computational Drug Discovery Methods
- Nanoplatforms for cancer theranostics
- Natural product bioactivities and synthesis
- Advanced Nanomaterials in Catalysis
- RNA modifications and cancer
- Plant-based Medicinal Research
- Graphene and Nanomaterials Applications
- Circular RNAs in diseases
- Pain Mechanisms and Treatments
- Cancer Mechanisms and Therapy
- Bone and Joint Diseases
- Ferroptosis and cancer prognosis
- Advanced biosensing and bioanalysis techniques
- Bone health and treatments
- Bioactive Natural Diterpenoids Research
- Ginseng Biological Effects and Applications
- Extracellular vesicles in disease
- Synthesis and biological activity
- Metabolomics and Mass Spectrometry Studies
- RNA Research and Splicing
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
China Academy of Chinese Medical Sciences
2015-2025
Harbin Medical University
2018-2025
First Affiliated Hospital of Harbin Medical University
2023-2025
Hunan University of Traditional Chinese Medicine
2023-2024
Jiangxi Science and Technology Normal University
2022-2024
Wuhan Institute of Technology
2022
Beijing YouAn Hospital
2020-2021
Capital Medical University
2020-2021
Xuchang University
2021
We describe LncACTdb 2.0 (http://www.bio-bigdata.net/LncACTdb/), an updated and significantly expanded database which provides comprehensive information of competing endogenous RNAs (ceRNAs) in different species diseases. have with more data several new features, including (i) manually curating 2663 experimentally supported ceRNA interactions from >5000 published literatures; (ii) expanding the scope up to 23 213 diseases/phenotypes; (iii) types such as circular pseudogenes; (iv) identifying...
Abstract Wu-tou decoction (WTD) has been extensively used for the treatment of rheumatoid arthritis (RA). Due to lack appropriate methods, pharmacological mechanisms WTD acting on RA have not fully elucidated. In this study, a list putative targets compositive compounds containing in were predicted by drugCIPHER-CS. Then, interaction network and known RA-related was constructed hub nodes identified. After constructing hubs, four topological features each hub, including degree, node...
Celastrol (cel) was one of the earliest isolated and identified chemical constituents Tripterygium wilfordii Hook. f. Based on a cel probe (cel-p) that maintained bioactivity parent compound, targets in cerebral ischemia-reperfusion (I/R) injury were comprehensively analyzed by quantitative proteomics method.We constructed an oxygen-glucose deprivation (OGD) model primary rat cortical neurons middle artery occlusion (MCAO) adult rats to detect direct binding I/R. By combining various...
Abstract Immunotherapy has good potential to eradicate tumors in the long term. However, due low immunogenicity of tumor cells, current cancer immunotherapies are not effective. To address this limitation, we constructed a BSA-FA functionalized iron-containing metal-organic framework (TPL@TFBF) that triggers potent systemic anti-tumor immune response by inducing ferroptosis and pyroptosis cells releasing large quantities damage-associated molecular patterns (DAMPs) induce immunogenicity,...
Sorafenib is the most widely used first-line drug for treatment of advanced hepatocellular carcinoma (HCC). Unfortunately, sorafenib resistance often limits its therapeutic efficacy. To evaluate efficacy artesunate against sorafenib-resistant HCC and to investigate underlying pharmacological mechanisms, a "sorafenib related gene-ART candidate target" interaction network was constructed, signaling axis consisting with target AFAP1L2 SRC, downstream FUNDC1-dependent mitophagy identified as...
Bacterial infection poses a significant challenge to wound healing and skin regeneration, leading substantial economic burdens on patients society. Therefore, it is crucial promptly explore develop effective methodologies for bacterial infections. Herein, we propose novel approach synthesizing nanostructures based antisense oligonucleotides (ASOs) through the coordination-driven self-assembly of Zn2+ with ASO molecules. This aims provide synergistic therapy chronic infections caused by...
Background and Objective: Peptic ulcer is a high incidence gastrointestinal disease in China. Berberine (BBR) natural product isolated from the Chinese herb Coptis chinensis Franch that has protective effects digestive diseases. We aimed to evaluate ability of BBR attenuate acute gastric induced by one-time administration ethanol rat. Methods: Tissue pathological morphology, macroscopic score, healing rate, serum levels inflammatory cytokines nitric oxide (NO), interleukin-6 (IL-6),...
Our previous study identified AKT1, AKT2 and AKT3 as unfavorable prognostic factors for patients with hepatocellular carcinoma (HCC). However, limited data are available on their exact mechanisms in HCC. Since microRNAs (miRNAs) implicated various human cancers including HCC, we aimed to screen miRNAs targeting AKTs investigate underlying HCC by integrating bioinformatics prediction, network analysis, functional assay clinical validation. Five online programs of miRNA target prediction...
LnCeVar (http://www.bio-bigdata.net/LnCeVar/) is a comprehensive database that aims to provide genomic variations disturb lncRNA-associated competing endogenous RNA (ceRNA) network regulation curated from the published literature and high-throughput data sets. 119 501 variation-ceRNA events thousands of samples cell lines, including: (i) more than 2000 experimentally supported circulating, drug-resistant prognosis-related lncRNA biomarkers; (ii) 11 418 somatic mutation-ceRNA TCGA COSMIC;...
Hepatic stellate cells (HSCs) are essential drivers of fibrogenesis. Inducing activated-HSC apoptosis is a promising strategy for treating hepatic fibrosis. 18beta-glycyrrhetinic acid (18β-GA) natural compound that exists widely in herbal medicines, such as Glycyrrhiza uralensis Fisch, which used multiple liver diseases, especially Asia. In the present study, we demonstrated 18β-GA decreased fibrosis by inducing activated HSCs. inhibited expression α-smooth muscle actin and collagen type I...
Abstract Due to the limitations of H 2 O under physiological conditions and defective activity, nanozyme‐catalyzed therapy for infected diabetic wound healing is still a huge challenge. Here, this work designs novel multifunctional hybrid glucose oxidase (GOx)–CeO @black phosphorus (BP)/Apt nanosheet that features GOx CeO dual enzyme loading with photothermal enhancement effect targeting ability treatment wounds in type II mice. Combined properties BP nanosheets, cascade nanozyme extremely...
Endometriosis (EMs), the ectopic planting of functional endometrium outside uterus, is a leading cause infertility and pelvic pain. As fundamental mRNA modification, N6-methyladenosine (m6A) participates in various pathological processes. However, role m6A RNA modification endometriosis remains unclear. The present study explores METTL3-mediated mechanisms involved endometriosis.The dominant regulators EMs were analysed using RT‒PCR. Candidate targets possible METTL3 assessed by m6A-mRNA...
Glycyrrhetinic acid (GA) shows great efficiency against non-small cell lung cancer (NSCLC), but the detailed mechanism is unclear, which has limited its clinical application. Herein, we investigated potential targets of GA NSCLC by activity-based protein profiling (ABPP) technology and combination histopathology proteomics validation. In vitro in vivo results indicated significantly inhibited via promotion peroxiredoxin-6 (Prdx6) caspase-3 (Casp3)-mediated mitochondrial apoptosis. This...
Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) presents great challenges due to various effects steroids on multi-system pathways involved into osteoblast differentiation, and osteoclast apoptosis, lipid metabolism, calcium metabolism coagulation. As one most frequently used herbs in Traditional Chinese Medicine formulas that are prescribed for regulation bone mineral therapeutic Achyranthes bidentata steroid-induced ONFH remain unclear. Thus, aim current study was...