A5017332714- Nanoparticle-Based Drug Delivery
- Nanoparticles: synthesis and applications
- Gut microbiota and health
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- CRISPR and Genetic Engineering
- Climate variability and models
- Graphene and Nanomaterials Applications
- MicroRNA in disease regulation
- Meteorological Phenomena and Simulations
- Probiotics and Fermented Foods
- Luminescence Properties of Advanced Materials
- Bioactive natural compounds
- Microplastics and Plastic Pollution
- Melanoma and MAPK Pathways
- Clostridium difficile and Clostridium perfringens research
- Tropical and Extratropical Cyclones Research
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Computational Drug Discovery Methods
- Animal Genetics and Reproduction
- Epigenetics and DNA Methylation
- Quantum Dots Synthesis And Properties
- PI3K/AKT/mTOR signaling in cancer
Beijing National Laboratory for Molecular Sciences
2015-2025
Peking University
2015-2025
South China Sea Institute Of Oceanology
2023-2025
Institute of Oceanology
2023-2025
Chinese Academy of Sciences
2011-2025
Northeastern University
2024-2025
Southern University of Science and Technology
2023-2025
University of Chinese Academy of Sciences
2019-2025
Yangtze University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2024
Abstract Freestanding, robust electrodes with high capacity and long lifetime are of critical importance to the development advanced lithium–sulfur (Li–S) batteries for next‐generation electronics, whose potential applications greatly limited by lithium polysulfide (LiPS) shuttle effect. Solutions this issue have mostly focused on design cathode hosts a polar, sulfurphilic, conductive network, or introduction an extra layer suppress LiPS shuttling, which either results in complex fabrication...
Abstract Sulfur (S) is an attractive cathode material with advantages including high theoretical capacity and low cost. However, issues such as the lithium polysulfide shuttle effect its insulating properties greatly limit future applications of lithium‐sulfur (Li‐S) batteries. Here, a viscous aqueous ink nanoscale S uniformly decorated on polar, metallically conductive titanium carbide MXene nanosheets (S@Ti 3 C 2 T x ) reported to address these issues. Importantly, it observed that Ti...
Background Extreme wildfires pose a serious threat to forest vegetation and human life because they spread more rapidly are intense than conventional wildfires. Detecting extreme is challenging due their visual similarities traditional fires, existing models primarily detect the presence or absence of fires without focusing on distinguishing providing warnings. Aims To test system for real time detection four Methods We proposed novel lightweight model, called LEF-YOLO, based YOLOv5...
Microplastics (MPs) are environmental pollutants and can be inhaled by humans to threaten health. The lung tissue, responsible for the gas exchange between body environment, is vulnerable MPs exposure. However, from perspective of cellular senescence, effect on cells tissues has not yet been deeply dissected. In this study, we reported that all four typical exhibited significant biological effects in term inducing senescence human derived A549 BEAS-2B vitro. We further found polyvinyl...
Itaconate is an anti-inflammatory metabolite involved in pathogen–macrophage interactions, but the mechanisms underlying its effect are not fully understood. Competitive cysteine profiling has been performed to interrogate itaconate's reactivity cell lysates, methods for analyzing targets of itaconation directly living macrophages still lacking. In this work, we developed a specific bioorthogonal probe, itaconate–alkyne (ITalk), quantitative and site-specific chemoproteomic inflammatory...
Breast cancer is the leading cause of death in women. Chemotherapy to inhibit proliferation cells considered be most important therapeutic strategy. The development long-circulating PEG and targeting liposomes a major advance drug delivery. However, techniques used liposome preparation mainly involve conventional liposomes, which have short half-life, high concentrations liver spleen reticuloendothelial system, no active targeting.Four kinds paclitaxel were prepared characterized by various...
Protected areas (PAs) play a key role in mitigating ecological crises. Currently, priority protected (PPAs) focus on biological conservation, and few studies have considered the connectivity between patches. Few formulated future conservation measures from two dimensions of security pattern (ESP) reserve effectiveness. To fill this gap, study use ESP to identify that meet objectives. We take Wuhan metropolitan area as research area. constructed framework for formulating development plans...
Abstract Titanium dioxide nanoparticles (TiO 2 NPs) are widely found in food‐related consumer products. Understanding the effect of TiO NPs on intestinal barrier and absorption is essential vital for safety assessment orally administrated NPs. In this study, cytotoxicity translocation two native NPs, these pretreated with digestion simulation fluid or bovine serum albumin were investigated undifferentiated Caco‐2 cells, differentiated cells monolayer. a concentration less than 200 µg ml –1...
As a novel fluorescent probe in the second near-infrared window, Ag2Se quantum dots (QDs) exhibit great prospect vivo imaging due to their maximal penetration depth and negligible background. However, behavior toxicity of QDs still largely remain unknown, which severely hinders wide-ranging biomedical applications. Herein, we systematically studied blood clearance, distribution, transformation, excretion, polyethylene glycol (PEG) coated mice after intravenous administration with high dose 8...
Abstract Purpose: mTOR is a validated target in cancer. It remains to be determined whether melanoma patients bearing mutation could selected for treatment with PI3K–AKT–mTOR pathway inhibitors. Experimental Design: A total of 412 samples were included. Gene aberrations all exons detected by Sanger sequencing and confirmed using Agilent's SureSelect Target Enrichment System. HEK293T cells stably expressing mutants constructed transcription activator-like effector nucleases technique....
Mucosal melanoma (MM) is the second most common subtype in Asian populations. Deregulation of microRNAs (miRNAs) has been extensively investigated various cancers, including cutaneous melanoma. However, roles miRNAs MM are unclear. In this study, we carried out miRNA profiling MM, and clinical biological miR-23a-3p MM. Methods: expression was profiled by microarray analysis. The quantitated qRT-PCR a cohort 117 patients with its prognostic significance evaluated. effect demonstrated both...
Rationale: Tumor energy metabolism has been a well-appreciated target of cancer therapy; however, the change cells between oxidative phosphorylation and glycolysis poses challenge to above.In this study, we constructed an innovative mitochondrion-targeted supramolecular "nano-boat" based on peptide self-assembly for tumor combined chemo-radiotherapy by simultaneously inhibiting dual metabolism.Methods: A lipophilic self-assembled positively charged cyclen were integrated fabricate brand new...
Aristolochic acid (AA), mainly derived from herbal Aristolochia and Asarum plants, was listed as a human carcinogen class I in 2002.Aristolochic nephropathy (AAN) is rapidly progressive tubulointerstitial nephritis urothelial cancer caused by AA.However, the targeting molecular mechanisms of AAs-induced nephrotoxicity are largely unclear.This study aims to dissect AA-induced nephrotoxicity.Activity-based protein profiling (ABPP) combination with cellular thermal shift assay (CETSA) performed...
Abstract From 17–22 July 2021, Henan Province experienced the most severe torrential rainfall event since 1975 with a maximum hourly precipitation of 201.9 mm appeared in Zhengzhou, which was largest thus far observed by meteorological observation stations over Chinese Mainland. The appearance long‐lived (21‐hr) northwestward‐moving mesoscale convective vortex (MCV) and its interaction parent system (MCS) crucial to produce extremely strong heavy Zhengzhou. backward trajectory analysis...
Hepatic stellate cells (HSCs) are essential drivers of fibrogenesis. Inducing activated-HSC apoptosis is a promising strategy for treating hepatic fibrosis. 18beta-glycyrrhetinic acid (18β-GA) natural compound that exists widely in herbal medicines, such as Glycyrrhiza uralensis Fisch, which used multiple liver diseases, especially Asia. In the present study, we demonstrated 18β-GA decreased fibrosis by inducing activated HSCs. inhibited expression α-smooth muscle actin and collagen type I...
Ovarian cancer is the second cause of death among gynecological malignancies. In this study, we designed a novel estrogen-targeted PEGylated liposome loaded with oxaliplatin and paclitaxel (ES-SSL-OXA/PTX) which could target estrogen receptor (ER) highly expressed on surface SKOV-3 cells to enhance therapeutic efficacy reduce side effects for tumor therapy. ES-SSL-OXA/PTX was prepared by thin film hydration method exhibited uniform spherical morphology. Encapsulation efficiency (EE) were...
In this paper, we propose a new type of nonlinear strict distance and similarity measures for intuitionistic fuzzy sets (IFSs). Our proposed methods not only have good properties, but also improve the drawbacks by Mahanta Panda (Int J Intell Syst 36(2):615-627, 2021) in which, example, their value [Formula: see text] is always equal to maximum 1 any number text]. To resolve these problems 2021), establish parametric measure IFSs prove that it satisfies axiomatic definition distances...
Abstract Background The pattern recognition receptor Dectin-1 was initially discovered to play a pivotal role in mediating pulmonary antifungal immunity and promoting neutrophil-driven inflammation. Recent studies have revealed that is overexpressed asthma, but the specific mechanism remains elusive. Additionally, has been implicated pyroptosis, hallmark of severe asthma airway Nevertheless, involvement non-classical pyroptosis signal caspase-11/4 its upstream regulatory mechanisms not...
Abstract Malaria continues to pose a serious global health threat, and artemisinin remains the core drug for malaria control. However, situation of resistance has become increasingly severe due emergence spread resistance. In recent years, significant progress been made in understanding mechanism action (MoA) artemisinin. Prior research on MoA mainly focused covalently bound targets that are alkylated by artemisinin‐free radicals. less attention given reversible noncovalent binding targets,...