A5114417948- Natural Compounds in Disease Treatment
- Nanoparticle-Based Drug Delivery
- Orthopedic Infections and Treatments
- Bone fractures and treatments
- Surgical site infection prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced Proteomics Techniques and Applications
- Drug Transport and Resistance Mechanisms
- Phytoplasmas and Hemiptera pathogens
- MicroRNA in disease regulation
- Pharmacological Effects of Natural Compounds
- Malaria Research and Control
- Drug-Induced Hepatotoxicity and Protection
- RNA Interference and Gene Delivery
- Nanoparticles: synthesis and applications
- Liver Disease Diagnosis and Treatment
- Carbohydrate Chemistry and Synthesis
- Plant Virus Research Studies
- Plant Pathogenic Bacteria Studies
- Cancer Research and Treatments
- Venous Thromboembolism Diagnosis and Management
- Natural product bioactivities and synthesis
- Kruppel-like factors research
- Characterization and Applications of Magnetic Nanoparticles
- Nanoplatforms for cancer theranostics
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Chinese Academy of Sciences
2024-2025
Third Hospital of Hebei Medical University
2020-2025
Hebei Medical University
2020-2025
Qingdao Institute of Bioenergy and Bioprocess Technology
2024-2025
University of Chinese Academy of Sciences
2024-2025
North University of China
2024
Jiangxi Agricultural University
2024
Renji Hospital
2022-2023
Shanghai Ocean University
2022-2023
Ferroptosis is a form of regulated cell death, characterized by excessive membrane lipid peroxidation in an iron- and ROS-dependent manner. Celastrol, natural bioactive triterpenoid extracted from Tripterygium wilfordii, shows effective anti-fibrotic anti-inflammatory activities multiple hepatic diseases. However, the exact molecular mechanisms action direct protein targets celastrol treatment liver fibrosis remain largely elusive. Here, we discover that exerts effects via promoting...
Abstract Background Sepsis involves life-threatening organ dysfunction and is caused by a dysregulated host response to infection. No specific therapies against sepsis have been reported. Celastrol (Cel) natural anti-inflammatory compound that shows potential systemic inflammatory diseases. This study aimed investigate the pharmacological activity molecular mechanism of Cel in models endotoxemia sepsis. Methods We evaluated efficacy mice macrophage cultures treated with lipopolysaccharide...
Celastrol (cel) was one of the earliest isolated and identified chemical constituents Tripterygium wilfordii Hook. f. Based on a cel probe (cel-p) that maintained bioactivity parent compound, targets in cerebral ischemia-reperfusion (I/R) injury were comprehensively analyzed by quantitative proteomics method.We constructed an oxygen-glucose deprivation (OGD) model primary rat cortical neurons middle artery occlusion (MCAO) adult rats to detect direct binding I/R. By combining various...
Aristolochic acid (AA), mainly derived from herbal Aristolochia and Asarum plants, was listed as a human carcinogen class I in 2002.Aristolochic nephropathy (AAN) is rapidly progressive tubulointerstitial nephritis urothelial cancer caused by AA.However, the targeting molecular mechanisms of AAs-induced nephrotoxicity are largely unclear.This study aims to dissect AA-induced nephrotoxicity.Activity-based protein profiling (ABPP) combination with cellular thermal shift assay (CETSA) performed...
Hepatic stellate cells (HSCs) are essential drivers of fibrogenesis. Inducing activated-HSC apoptosis is a promising strategy for treating hepatic fibrosis. 18beta-glycyrrhetinic acid (18β-GA) natural compound that exists widely in herbal medicines, such as Glycyrrhiza uralensis Fisch, which used multiple liver diseases, especially Asia. In the present study, we demonstrated 18β-GA decreased fibrosis by inducing activated HSCs. inhibited expression α-smooth muscle actin and collagen type I...
Background Monkeypox or mpox virus (mpox) is a double-stranded DNA that poses significant threat to global public health security. The F3 protein, encoded by mpox, an apoenzyme believed possess RNA-binding domain (dsRBD). However, limited research has been conducted on its function. In this study, we present data the transcriptomics and proteomics of F3L-transfected HEK293T cells, aiming enhance our comprehension F3L. Methods gene expression profiles pCAGGS-HA-F3L transfected cells were...
Abstract Malaria continues to pose a serious global health threat, and artemisinin remains the core drug for malaria control. However, situation of resistance has become increasingly severe due emergence spread resistance. In recent years, significant progress been made in understanding mechanism action (MoA) artemisinin. Prior research on MoA mainly focused covalently bound targets that are alkylated by artemisinin‐free radicals. less attention given reversible noncovalent binding targets,...
Aristolochic acid nephropathy (AAN) is characterized by acute proximal tubule necrosis and immune cell infiltration, contributing to the global burden of chronic kidney disease urothelial cancer. Although has been defined as primary target aristolochic acids I (AAI), mechanistic underpinning gross renal deterioration caused AAI not explicitly explained, prohibiting effective therapeutic intervention. To this point, we employed integrated single-cell RNA-Seq, bulk mass spectrometry–based...
Abstract Background Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions people in developing countries. In the history anti-malaria campaign, chloroquine (CQ) has played an indispensable role, however, its mechanism action (MoA) not fully understood. Methods We used principle photo-affinity labeling and click chemistry-based functionalization design CQ probe developed combined deconvolution strategy activity-based protein profiling (ABPP) mass...
Background In this study, we investigated the epidemiological characteristics and predictors of diabetic peripheral neuropathy (DPN) in adult patients with type 2 diabetes mellitus (DM). Methods The study was designed as a retrospective cohort trial at First Affiliated Hospital Wenzhou Medical University. From January 2017 to December 2020, total 1,262 DM were enrolled assess risk factors for DPN. divided into two groups (DPN group non-DPN group). Mann–Whitney U test or t -test, receiver...
Cardiovascular disease (CVD) is the major cause of disability-adjusted life years (DALY) and death globally. The most common internal modification mRNA N6-adenosylate methylation (m6A). Recently, a growing number studies have been devoted to researching cardiac remodeling mechanisms, especially m6A RNA methylation, revealing connection between cardiovascular diseases. This review summarized current understanding regarding elucidated dynamic modifications writers, erasers, readers....
Abstract Idiopathic pulmonary fibrosis (IPF) represents a chronic interstitial lung disease with an unclear underlying mechanism and currently lacks definitive treatment. Cordyceps sinensis (CS), renowned for its pharmacological properties in traditional Chinese medicine extensive use treatment, holds promise as therapeutic agent IPF. However, the specific role of CS treating IPF remains unclear. In this study, we aimed to assess efficacy unravel potential mechanisms. Our results demonstrate...
ABSTRACT The insufficient infiltration and functional inhibition of CD8 + T cells due to tumor microenvironment (TME) are considered enormous obstacles anti‐tumor immunotherapy. Herein, a pH‐responsive core‐shell manganese phosphate nanomodulator co‐loading siPD‐L1 Mn 2+ into nanoparticles coated with hyaluronic acid was prepared, which aimed at the bidirectional reprogramming microenvironment: (1) “Brakes off,” restoring function by knockdowning PD‐L1 expression cells; (2) “Step on...
ABSTRACT Clostridium ljungdahlii , as a model acetogen strain, represents novel platform for biotechnological production CO 2 fixation. The genome of C. harbors two gene loci associated with glycyl radical enzyme-associated microcompartments (GRMs), which are predicted to play essential roles in choline and 1,2-propanediol (1,2-PD) metabolism. This study validated the functions these GRM identified inducible promoters, P choline1 was induced by choline, while 1,2-PD 1,2-PD. Subsequently,...
Background: The use of cephalosporins for surgical site infection (SSI) prevention has become a clinical routine, however, high-level evidence regarding the optimal generation open fractures is currently limited. This study aims to investigate association between and SSI risk in fractures. Methods: prospective cohort used data from Surgical Site Infection Orthopedic Surgery (SSIOS), prospectively maintained database, conducted at tertiary orthopedic university hospital October 2014 December...
The in-hospital death rate in cases of hip fracture ranges from 6% to 10%. Pneumonia is a serious complication for patients that contributes longer hospital stays and higher mortality rates; however, the prevalence risk factors are not well established. To address this issue, present study investigated incidence postoperative pneumonia (IHPOP) following geriatric intertrochanteric surgery.Information on 1495 (>65 years) who underwent surgery at our between October 2014 December 2018 was...