A5037062221- Fungal Biology and Applications
- Microbial Natural Products and Biosynthesis
- Research on Leishmaniasis Studies
- Enzyme function and inhibition
- Plant Pathogens and Fungal Diseases
- Redox biology and oxidative stress
- Phytochemical Studies and Bioactivities
- Genomics, phytochemicals, and oxidative stress
- Polysaccharides and Plant Cell Walls
- Parasites and Host Interactions
- Berberine and alkaloids research
- Malaria Research and Control
- Alkaloids: synthesis and pharmacology
- Plant chemical constituents analysis
- Drug Transport and Resistance Mechanisms
- Platelet Disorders and Treatments
- Selenium in Biological Systems
- Advanced Nanomaterials in Catalysis
- Garlic and Onion Studies
- 14-3-3 protein interactions
- Metal-Catalyzed Oxygenation Mechanisms
- Organoselenium and organotellurium chemistry
- Biocrusts and Microbial Ecology
- Ion Channels and Receptors
- Fungal and yeast genetics research
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Huanghe Science and Technology College
2022
Rush University Medical Center
2018-2021
China Academy of Chinese Medical Sciences
2021
Xinjiang Institute of Materia Medica
2021
Institute of Chinese Materia Medica
2021
Institute of Microbiology
2017-2021
Chinese Academy of Sciences
2017-2021
State Key Laboratory of Mycology
2021
Peking University
2018-2020
Abstract Artemisinins are a family of sesquiterpene lactones originally derived from the sweet wormwood ( Artemisia annua ). Beyond their well‐characterized role as frontline antimalarial drugs, artemisinins have also received increased attention for other potential pharmaceutical effects, which include antiviral, antiparsitic, antifungal, anti‐inflammatory, and anticancer activities. With concerted efforts in further preclinical clinical studies, artemisinin‐based drugs to be viable...
The composition of serum is extremely complex, which complicates the discovery new pharmacodynamic biomarkers via proteome for disease prediction and diagnosis. Recently, nanoparticles have been reported to efficiently reduce proportion high-abundance proteins enrich low-abundance in serum. Here, we synthesized a silica-coated iron oxide nanoparticle developed highly efficient reproducible protein corona (PC)-based proteomic analysis strategy improve range analysis. We identified 1,070 with...
Abstract Background Acetaminophen (APAP)-induced hepatotoxicity has attracted considerable attention in clinical settings due to the limited treatment options available. Liensinine stands out as a key alkaloid known for its pharmaceutical activities. However, role of liensinine mitigating APAP-induced liver injury remains unclear. Objective The aim study was explore protective effects against injury. Methods C57BL/6 male mice were treated with dose 200 mg/kg N-acetylcysteine or varying doses...
Schistosomiasis is a widespread human parasitic disease currently affecting over 200 million people. Chemotherapy for schistosomiasis relies exclusively on praziquantel. Although significant advances have been made in recent years to reduce the incidence and intensity of schistosome infections, these gains will be at risk should drug-resistant parasites evolve. Thioredoxin glutathione reductase (TGR) selenoprotein parasite essential survival schistosomes mammalian host. Several...
By deleting the COP9 signalosome subunit PfcsnE from Pestalotiopsis fici, seven compounds that were newly produced by mutant could be characterized, including five new structures, pestaloficins A–E (1 and 3–6). Pestaloficin A (1) represents a type of dimeric cyclohexanone derivative linked through an unprecedented pentacyclic spiral ring.
Members of the FAD/NAD-linked reductase family are recognized as crucial targets in drug development for cancers, inflammatory disorders, and infectious diseases. However, individual FAD/NAD reductases difficult to inhibit a selective manner with off-target inhibition reducing usefulness identified compounds. Thioredoxin glutathione (TGR), high molecular weight thioredoxin reductase-like enzyme, has emerged promising target treatment schistosomiasis, parasitosis afflicting more than 200...
By disruption of LaeB, a global regulator recently characterized in <italic>Aspergillus nidulans</italic>, eight cryptic compounds the mutant were identified, including seven polyketides and one NRPS-like product.
Fragment screening is a powerful drug discovery approach particularly useful for enzymes difficult to inhibit selectively, such as the thiol/selenol-dependent thioredoxin reductases (TrxRs), which are essential and druggable in several infectious diseases. Several known inhibitors reactive electrophiles targeting selenocysteine-containing C-terminus thus often suffering from off-target reactivity vivo. The lack of structural information on interaction modalities C-terminus-targeting...
One new coumarin, muralatin R, was isolated from the leaves of Murraya alata Drake (Rutaceae). Its structure elucidated by extensive analysis NMR and MS data, along with specific rotation comparison. Muralatin R found to be capable activating transient receptor potential vanilloid 1 (TRPV1) channel through desensitization mechanism. The results supply reference for clarification therapeutic basis mechanism action plants treating psychogenic pain or somatoform disorders.
By genome mining and LC-MS analysis, a novel cyclodepsipeptide isaridin H (<bold>1</bold>) seven known analogs were isolated genetically identified from guanophilic fungus<italic>Amphichorda guana</italic>.
We present the first example that a single fungal HR-PKS could synthesize multiple complicated compounds.
Polyphyllins are the active ingredients of medicinal plant Paris polyphylla. The biosynthesis different types polyphyllins all require catalysis glycosyltransferases. Even though significant efforts have been made to identify PpUGTs capable catalyzing initial glycosylation reaction, specific glycosyltransferases responsible for synthesis trillin not reported in P. Here, we identified a new synthase, named PpUGT91BP1, which was highly expressed rhizome. Importantly, PpUGT91BP1 could...
Abstract The phytochemical investigation of the leaves and stems Murraya tetramera C.C. Huang, a traditional folk medicine used as an anti‐inflammatory agent, yielded 19 simple carbazole alkaloids, two which (1‐ethoxy‐3‐methyl‐9 H ‐carbazol‐2‐ol ( 1 ) 7‐hydroxy‐2,8‐dimethoxy‐6‐methyl‐9 ‐carbazole‐1‐carbaldehyde 2 )) are new ones. structures compounds were determined by extensive spectroscopic analysis including NMR HR‐EI‐MS experiments, well comparison with reported data. Most isolates...