A5100360938- Vibrio bacteria research studies
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Bacteriophages and microbial interactions
- Hepatitis B Virus Studies
- RNA modifications and cancer
- Aquaculture disease management and microbiota
- Escherichia coli research studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Pleural and Pulmonary Diseases
- Cancer, Lipids, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Cervical Cancer and HPV Research
- Circular RNAs in diseases
- Mycobacterium research and diagnosis
- Urban Heat Island Mitigation
- Clostridium difficile and Clostridium perfringens research
- Herpesvirus Infections and Treatments
- Effects of Vibration on Health
- Genomics and Phylogenetic Studies
- Cytokine Signaling Pathways and Interactions
- Vibration Control and Rheological Fluids
- Identification and Quantification in Food
Columbia University
2022-2024
Columbia University Irving Medical Center
2022-2024
Nanjing Forestry University
2021-2024
Yangzhou University
2019-2024
Yuhuangding Hospital
2019-2024
Qingdao University
2019-2024
Cancer Genetics (United States)
2022-2024
Southwest University
2024
Ningbo First Hospital
2020-2023
Chinese PLA General Hospital
2023
Neurodegeneration and astrocytic activation are pathologic hallmarks of progressive multiple sclerosis (MS) can be quantified by serum neurofilament light chain (sNfL) glial fibrillary acidic protein (sGFAP). We investigated sNfL sGFAP as tools for stratifying patients with MS based on progression disease activity status.We leveraged our Comprehensive Longitudinal Investigation at the Brigham Women's Hospital (CLIMB) natural history study, which includes clinical, MRI data samples collected...
Gastric cancer (GC) is among the most malignant tumor types, which causes heavy healthy and economic burden to people societies all around world. Establishment of an effective set prognostic marker will benefit a lot treatment GC patients clinically. Ferroptosis newly identified regulated cell death modality, with tight relevance development. However, its application in prognosis has not been studied detail. Deregulated messenger RNA (mRNA) long non-coding (lncRNA) expression profile can...
Abstract YEATS domain-containing protein GAS41 is a histone reader and oncogene. Here, through genome-wide CRISPR-Cas9 screenings, we identify as repressor of ferroptosis. interacts with NRF2 critical for to activate its targets such SLC7A11 modulating By recognizing the H3K27-acetylation (H3K27-ac) marker, recruited promoter, independent binding. bridging interaction between H3K27-ac acts an anchor on chromatin in promoter-specific manner transcriptional activation. Moreover, GAS41-mediated...
Liver cancer is a generic term referring to several types arising from the liver. Every year, liver causes lots of deaths and other burdens people all over world. Though techniques in diagnosis therapy have undergone significant advances, current status treating not satisfactory enough. The improvement for prognosis patients will be great supplement treatment cancer. Cuproptosis newly identified regulatory cell death type, which may close connection pathology. Here, we developed prognostic...
IEM101, a Vibrio cholerae O1 El Tor Ogawa strain naturally deficient in CTXPhi, was previously selected as live cholera vaccine candidate. To make better and safer that can induce protective immunity against both the bacteria toxin (CT), new candidate, IEM108, constructed by introducing ctxB gene an Tor-derived rstR into IEM101. The codes for antigen CTB subunit, mediates phage immunity. stable expression of two genes managed chromosome-plasmid lethal balanced system based on housekeeping...
STAT6 participates in classical IL-4/IL-13 signaling and stimulator of interferon genes-mediated antiviral innate immune responses. Aberrations STAT6-mediated are linked to development asthma diseases the system. In addition, remains constitutively active multiple types cancer. Therefore, targeting is an attractive proposition for treating related diseases. Although a lot known about role transcriptional regulation, molecular details on how recognizes binds specific segments DNA exert its...
Purpose Suicide is a global concern, especially among young people. prediction models have the potential to make it easier identify patients who are at high risk of suicide, but they very little predictive power when there positive value for suicide mortality. Therefore, aim study uncover factors associated with by self-poisoning and further provide trustworthy nomogram predict poisoned patients. Methods This prospectively enrolled 237 were treated poisoning Fifth Medical Center PLA General...
This study was designed to determine the Human papillomavirus (HPV) prevalence and its distribution of genotypes in various regions Yunnan Province, China.In this study, participants were recruited during routine gynecologic examination between Oct 2013 Feb 2015. A total 17,898 women recruited. Polymerase chain reaction used for detecting HPV positive samples geno-array test genotyping.The overall infection rate (19.9 %) among south-western significantly higher (P = 0.001) than that...
Abstract Background Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions people in developing countries. In the history anti-malaria campaign, chloroquine (CQ) has played an indispensable role, however, its mechanism action (MoA) not fully understood. Methods We used principle photo-affinity labeling and click chemistry-based functionalization design CQ probe developed combined deconvolution strategy activity-based protein profiling (ABPP) mass...
Given rapid global urban development, increases to impervious surfaces, population growth, building construction, and energy consumption result in the heat island (UHI) phenomenon. However, spatial extent of UHIs is not clearly mapped many UHI studies based on a remote sensing approach. Therefore, we developed method extract during period from 2000 2021 Nanjing, China, explored impact two- three-dimensional expansion intensity. After cropland effects (i.e., bare soil) were eliminated, our...
Background PANoptosis is a newly discovered cell death type, and tightly associated with immune system activities. To date, the mechanism, regulation application of in tumor largely unknown. Our aim to explore prognostic value PANoptosis-related genes colon adenocarcinoma (COAD). Methods Analyzing data from The Cancer Genome Atlas-COAD (TCGA-COAD) involving 458 COAD cases, we concentrated on five pathways Molecular Signatures Database (MSigDB) comprehensive set immune-related genes. approach...
The prevalence and genotype distribution of human papillomavirus (HPV) vary throughout the world. To assess HPV among three ethnic groups in two geographic locations north‐western Yunnan, we recruited 522 women Shangri‐le (n = 255) Lijiang 267). PCR amplification DNA was performed on cervical cells from these using consensus primer systems (MY09/11 GP5/6). Amplified‐HPV genotyped GenoArray test. Geographically, significantly higher ( P 0.002) than women. Infections with high‐risk (HR)‐HPV...
The effect of Tsusanli acupuncture point (S36 acupoint) stimulation on splenic natural killer (NK) cytotoxicity was examined in Fischer 344 (F344) rats. Electro-acupuncture (voltage intensity, 1 to 5 V; duration, ms; frequency, Hz) applied bilateral S36 acupoints once a day (1 h) for 3 d. NK measured by the standard 4-h 51Cr release assay. Successive treatment d significantly enhanced (p < 0.001) first after final as compared that control. However, similar abdominal muscle did not influence...
Abstract Thallium is highly toxic and its effects are cumulative. The clinical symptoms of thallium poisoning non-specific, thereby delaying admission treatment. This study aimed to summarize the features treatment experience patients with delayed who poisoning. We conducted a retrospective descriptive analysis in our hospital from 2008 2018 had experienced delay admission. time symptom onset was assessed. were divided into 3 groups analyses their characteristics, including basic patient...