A5006149699- Hepatitis C virus research
- Hepatitis B Virus Studies
- HIV Research and Treatment
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Viral Infections and Vectors
- HIV/AIDS Research and Interventions
- Mosquito-borne diseases and control
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- RNA modifications and cancer
- Systemic Lupus Erythematosus Research
- Cervical Cancer and HPV Research
- HIV, Drug Use, Sexual Risk
- Hepatitis Viruses Studies and Epidemiology
- Plant Molecular Biology Research
- Genome Rearrangement Algorithms
- Viral gastroenteritis research and epidemiology
- Cardiomyopathy and Myosin Studies
- Influenza Virus Research Studies
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- SARS-CoV-2 and COVID-19 Research
- Algorithms and Data Compression
Queen Elizabeth Hospital
2025
Shandong Center for Disease Control and Prevention
2025
Kunming University of Science and Technology
2015-2024
Shanxi Medical University
2024
Shanxi Academy of Medical Sciences
2024
Xinxiang University
2024
Chinese Center For Disease Control and Prevention
2024
First Affiliated Hospital of Zhengzhou University
2023
Northwestern University
2020-2022
Penn State Milton S. Hershey Medical Center
2017-2022
In the past decade, carbapenemase-producing Enterobacteriaceae (CPE) have been reported worldwide. Emergence of strains among has a challenge for treatment clinical infection. The present study was undertaken to investigate characteristics carbapenem-resistant Klebsiella pneumoniae recovered from an outbreak that affected 17 neonatal patients in intensive care unit (NICU) Kunming City Maternal and Child health Hospital, which is located city far southwest China. Minimum inhibitory...
Dilated cardiomyopathy (DCM) is a major cause of sudden cardiac death and heart failure, it characterized by genetic clinical heterogeneity, even for some patients with very poor prognosis; in the majority cases, DCM necessitates transplant. Genetic mutations have long been considered to be associated this disease. At present, over 50 genes related documented. This study was carried out elucidate characteristics gene DCM. The candidate that may include MYBPC3, MYH6, MYH7, LMNA, TNNT2, TNNI3,...
Significance DOT1L is a histone methyltransferase that catalyzes H3K79 methylation, chromatin modification correlated with active transcription. Inhibition of DOT1L’s catalytic activity has been studied for cancer therapy; however, the mechanisms underlying its function in development and pathogenesis remain elusive. To understand catalytic-dependent catalytic-independent functions DOT1L, we generated dead null embryonic stem cells found but not activity, required establishing proper...
ABSTRACT Hepatitis C virus (HCV)-related research has been hampered by the lack of appropriate small-animal models. It reported that tree shrews, or tupaias ( Tupaia belangeri ), can be infected with serum-derived HCV. However, these reports do not firmly establish tupaia as a reliable model HCV infection. Human CD81, scavenger receptor class B type I (SR-BI), claudin 1 (CLDN1), and occludin (OCLN) are considered essential receptors coreceptors for cell entry. In present study, roles...
GB virus C (GBV-C) is prevalent globally and particularly among individuals at risk of parental exposures. Based on genetic diversity, this now classified into six genotypes many subtypes with distinct geographical distribution. In study, 120 Injecting Drug Users (IDUs) were recruited from Yunnan province, China. Among them, 43 (35.8%) positive for GBV-C RNA, 70 (58.3%) 103 (85.8%) sero-positive HIV-1 HCV respectively. This revealed 18.3% IDUs having GBV-C/HIV/HCV triple infection, which...
Objective: To investigate the current status and related factors of antiviral treatment for chronic hepatitis B virus (HBV) infection in rural communities China. Methods: In 2023, 866 HBV-infected individuals from Zhangqiu District, Jinan City, were included study. Basic information, disease conditions infected collected through questionnaires, specimen collection laboratory tests. Univariate multivariate logistic regression used to analyze rate those who met indications treatment. Results:...
This study was designed to determine the Human papillomavirus (HPV) prevalence and its distribution of genotypes in various regions Yunnan Province, China.In this study, participants were recruited during routine gynecologic examination between Oct 2013 Feb 2015. A total 17,898 women recruited. Polymerase chain reaction used for detecting HPV positive samples geno-array test genotyping.The overall infection rate (19.9 %) among south-western significantly higher (P = 0.001) than that...
Abstract Background Genome evolution is shaped not only by nucleotide substitutions, but also structural changes including gene and genome duplications, insertions, deletions order rearrangements. The most popular methods for reconstructing phylogeny from rearrangements include GRAPPA MGR. However these are limited to cases where equal content or few can be assumed. Since conserved duplicated regions present in many chloroplast genomes, the inference of inverted repeats needed analysis...
To assess the prevalence, all-cause mortality and determinants of advanced HIV disease (AHD) or severe immunosuppression (SIS) in rural–urban communities Southwestern China. Retrospective cohort study. Data on HIV/AIDS cases reported 2005–20 were collected from Case Report System. A binary logistic regression model assessed risk factors AHD/SIS prevalence. Survival curves across regions compared using Kaplan–Meier estimates log-rank tests. Determinants identified Cox proportional hazard...
The tree shrew (Tupaia belangeri chinensis), a small animal widely distributed in Southeast Asia and southwest China, has the potential to be developed as an model for hepatitis C. To determine susceptibility of C virus (HCV) infection vitro vivo, well-established HCV, produced from J6/JFH1-Huh7.5.1 culture system, was used infect cultured primary tupaia hepatocytes (PTHs) shrews. results showed that HCV genomic RNA HCV-specific nonstructural protein 5A (NS5A) could detected PTH cell days...
The prevalence and genotype distribution of human papillomavirus (HPV) vary throughout the world. To assess HPV among three ethnic groups in two geographic locations north‐western Yunnan, we recruited 522 women Shangri‐le (n = 255) Lijiang 267). PCR amplification DNA was performed on cervical cells from these using consensus primer systems (MY09/11 GP5/6). Amplified‐HPV genotyped GenoArray test. Geographically, significantly higher ( P 0.002) than women. Infections with high‐risk (HR)‐HPV...
Human Pegivirus-1 (HPgV-1) may have a beneficial impact on disease progression in human immunodeficiency virus-1 (HIV-1) infection. However, analysis of the genotypic diversity HPgV-1 and its relevance to HIV-1 remains limited. A total 1062 HIV-1-infected individuals were recruited all sixteen prefectures Yunnan province, China. The reverse transcription nested polymerase chain reaction (RT-nPCR), phylogenetic analyses, clinical data analyses used detect infection, determine genotype,...
An outbreak of dengue virus (DENV) occurred in Yunnan province. More than 2,000 individuals were infected from August to November 2013. In this study, we aimed characterize the origin and prevalence DENV Dehong prefecture province using phylogenetic evolutionary analyses strains collected local patients foreign travelers.A total 41 DENV-positive serum samples randomly travelers who entered China at Ruili port or with fever province, China. The envelope (E) gene was amplified sequenced....
Zika virus (ZIKV) is a mosquito-borne flavivirus that caused the public health emergency. Recently, we have proved novel small animal tree shrew was susceptive to ZIKV infection and presented most common rash symptoms as patients. Here further cultured primary cells from different tissues of this determine tissue tropism in vitro. The results showed kidney, lung, liver, skin aorta were permissive could support viral replication by detection specific RNA intra- extra-cells. In comparing,...
Animal models of Zika virus (ZIKV) infection have recently been established in mice, guinea pigs, and nonhuman primates. Tree shrews (Tupaia belangeri) are an emerging experimental animal biomedical applications, but their susceptibility to ZIKV has not explored. In the present study, we show that subcutaneous inoculation led rapid viremia viral secretion saliva, as well typical dermatological manifestations characterized by massive diffuse skin rash on trunk. Global transcriptomic...
Our study aimed to identify inclisiran-related adverse events(AEs) for primary hypercholesterolemia and arteriosclerotic cardiovascular disease(ASCVD) from the US FDA Adverse Event Reporting System (FAERS) database, analyzing its links AEs in overall patient population sex-specific subgroups improve medication safety.
Arabidopsis RNA polymerase II (RNAPII) C-terminal domain (CTD) phosphatases regulate stress-responsive gene expression and plant development via the dephosphorylation of serine (Ser) residues CTD.Some these (CTD phosphatase-like 1 (CPL1) to CPL3) negatively ABA stress responses.Here, we isolated AtCPL5, a cDNA encoding protein containing two CTD phosphatase domains (CPDs).• To characterize analyzed patterns subcellular localization, investigated various phenotypes AtCPL5overexpressors...