A5100664460- Cardiomyopathy and Myosin Studies
- RNA Research and Splicing
- Protein purification and stability
- Influenza Virus Research Studies
- Cancer-related Molecular Pathways
- Galectins and Cancer Biology
- Wastewater Treatment and Nitrogen Removal
- Liver Disease and Transplantation
- Intraoperative Neuromonitoring and Anesthetic Effects
- Hepatitis B Virus Studies
- Pneumonia and Respiratory Infections
- Epigenetics and DNA Methylation
- Trypanosoma species research and implications
- Intraocular Surgery and Lenses
- RNA modifications and cancer
- Nuclear Structure and Function
- Cardiac Arrest and Resuscitation
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Immunology Research
- Urologic and reproductive health conditions
- Hepatitis Viruses Studies and Epidemiology
- Antibiotic Use and Resistance
- Liver Disease Diagnosis and Treatment
- Urological Disorders and Treatments
- Pediatric health and respiratory diseases
China Medical University
2015-2021
Jinan University
2021
Institute of Laboratory Animal Science
2021
Kunming University of Science and Technology
2015-2018
Affiliated Hospital of Hebei University
2014
Dilated cardiomyopathy (DCM) is a major cause of sudden cardiac death and heart failure, it characterized by genetic clinical heterogeneity, even for some patients with very poor prognosis; in the majority cases, DCM necessitates transplant. Genetic mutations have long been considered to be associated this disease. At present, over 50 genes related documented. This study was carried out elucidate characteristics gene DCM. The candidate that may include MYBPC3, MYH6, MYH7, LMNA, TNNT2, TNNI3,...
Hypertrophic cardiomyopathy (HCM), one of the most common forms myocardial diseases, is major cause sudden cardiac death in young adults and competitive athletes. Analyses gene mutations associated with HCM are valuable for its molecular diagnosis, genetic counseling, management familial HCM. To dissect relationship between clinical presentation HCM, characterizations 19 HCM-related genes 18 patients (8 cases from 6 pedigrees 10 without HCM) were detected using next-generation sequencing...
Discovery of 5-hydroxymethylcytosine (5hmC) in mammalian genomes has excited the field epigenetics, but information on genome-wide distribution 5hmC is limited. Globozoospermia a rare severe cause male infertility. To date, epigenetic mechanism, especially profiles involved globozoospermia progression, remains largely unknown. Here, utilizing chemical labeling and biotin-enrichment approach followed by Illumina HiSeq sequencing, we showed that (i) 6664, 9029 6318 genes contain normal,...
As a common cardiac disease mainly caused by gene mutations in sarcomeric cytoskeletal, calcium-handling, nuclear envelope, desmosomal, and transcription factor genes, inherited cardiomyopathy is becoming one of the major etiological factors sudden death (SCD) heart failure (HF). This characterized remarkable genetic heterogeneity, which makes it difficult to screen for pathogenic using Sanger sequencing. In present study, three probands, with familial hypertrophic (FHCM) two dilated (FDCM),...
Inherited cardiomyopathy is the major cause of sudden cardiac death (SCD) and heart failure (HF). The disease associated with extensive genetic heterogeneity; pathogenic mutations in sarcomere protein genes, cytoskeletal genes nuclear envelope have been linked to its etiology. Early diagnosis conducive clinical monitoring allows for presymptomatic interventions as needed. In present study, entire coding sequences flanking regions 12 (cardiomyopathy)-related [namely myosin, heavy chain 7,...
Yunnan is considered to be a geographical hotspot for the introduction, mutation and recombination of several viruses in China. However, there are limited data regarding genotypic profiles hepatitis B virus (HBV) this region. In study, we characterized 206 HBV strains isolated from chronic patients Yunnan, Initial genotyping based on 1.5 kb sequences revealed that genotype C was most prevalent at 52.4 % (108/206), followed by 30.6 (63/206) unclassified genotypes 17.0 (35/206). To...
Rabbit hepatitis E virus (HEV) has been reported for years and is thought to have the potential zoonotic transmission from rabbits humans. As reported, HEV genotype 3 (gt3) most prevalent form of in rabbits. To determine prevalence commercial rabbit livers, 176 liver samples were collected an abattoir Hebei Province, China. Three (1.7%) tested positive RNA HEV-ORF2 (open reading frames-2). Sequence analysis showed that three isolates shared high identities with each other (94.08–98.85%)....
Objective To observe the therapeutic effect of low molecular weight heparin on anterior ischemic optic neuropathy (AION).Methods Eighty patients (86 eyes) diagnosed as with AION were divided into treatment group (40 patients,44 and control patients,42 eyes).The two groups both received injection Ainpocetine,Coenzyme A ATP,retrobulbar dexamethasone,anisodamine lidocaine.All took vitamin B1 mecobalamine,14 days one course.The voluntarily infused abdominally subcutaneously 5000u LMWH every day...
Objective Quadrivalent influenza vaccines contain two lineages of type B virus, this study aimed to assess whether the result single radial immunodiffusion (SRID) are accurate. The cross-interference hemagglutinins remains unknown. Methods We detected vaccine samples developed by Jiangsu GDK Biological Technology Co., ltd SRID. Results There was no significant difference between HA content antigen reagent, bulk sample and mixed within 10 40 μg/ml (P>0.05). Then each...