A5101539535- Proteoglycans and glycosaminoglycans research
- Alzheimer's disease research and treatments
- Glycosylation and Glycoproteins Research
- Protein Hydrolysis and Bioactive Peptides
- Carbohydrate Chemistry and Synthesis
- RNA Research and Splicing
- RNA modifications and cancer
- Cholinesterase and Neurodegenerative Diseases
- RNA and protein synthesis mechanisms
- Wnt/β-catenin signaling in development and cancer
- Cancer-related Molecular Pathways
- Gut microbiota and health
- Virus-based gene therapy research
- Epigenetics and DNA Methylation
- Invertebrate Immune Response Mechanisms
- Cancer-related gene regulation
- Biochemical effects in animals
- Ubiquitin and proteasome pathways
- Enzyme Production and Characterization
- Phytochemicals and Antioxidant Activities
- Plant biochemistry and biosynthesis
- Phytase and its Applications
- Cancer, Hypoxia, and Metabolism
- Pharmacological Effects and Toxicity Studies
- Traditional Chinese Medicine Analysis
Qinghai University
2020-2025
Research Center for Eco-Environmental Sciences
2023-2025
State Key Laboratory of Environmental Chemistry and Ecotoxicology
2025
Chinese Academy of Sciences
2001-2025
University of Chinese Academy of Sciences
2023-2025
Jilin Agricultural University
2022-2024
Children's Hospital of Chongqing Medical University
2024
Shandong First Medical University
2022-2024
Shanxi Agricultural University
2024
Ministry of Agriculture and Rural Affairs
2024
Abstract Epigallocatechin gallate (EGCG) from green tea can induce apoptosis in cancerous cells, but the underlying molecular mechanisms remain poorly understood. Using SPR and NMR, here we report a direct, μM interaction between EGCG tumor suppressor p53 ( K D = 1.6 ± 1.4 μM), with disordered N-terminal domain (NTD) identified as major binding site 4 2 μM). Large scale atomistic simulations (>100 μs), SAXS AUC demonstrate that EGCG-NTD is dynamic causes emergence of subpopulation compact...
In February 2016, the World Health Organization declared a Public Emergency of International Concern on Zika Virus (ZIKV), because its association with severe fetal anomalies congenitally infected humans. This has led to urgent efforts by academic, federal, and industry research groups improve our understanding pathogenesis ZIKV develop detection methods, therapeutic strategies, vaccines. Although we still do not have entire picture ZIKV, extensive been conducted related pathogenic...
Abstract Prion‐like transcellular spreading of tau in Alzheimer's Disease (AD) is mediated by binding to cell surface heparan sulfate (HS). However, the structural determinants for tau–HS interaction are not well understood. Microarray and SPR assays structurally defined HS oligosaccharides show that a rare 3‐ O ‐sulfation (3‐ ‐S) significantly enhances binding. In Hs3st1 −/− (HS ‐sulfotransferase‐1 knockout) cells, reduced ‐S levels diminished both internalization tau. culture, addition...
We have been effectively protected by disposable propylene face masks during the COVID-19 pandemic; however, they may pose health risks due to release of fine particles and chemicals. measured micro/nanoparticles organic chemicals in medical masks, surgical (K)N95 respirators. In breathing-simulation experiment, no notable differences were found total number among mask types or between breathing intensities. However, when considering subranges, <2.5 μm accounted for ∼90% micro/nanoparticles....
Self-assembly of the microtubule-associated protein tau into neurotoxic oligomers, fibrils, and paired helical filaments, cell-to-cell spreading these pathological species are critical processes underlying pathogenesis Alzheimer's disease other tauopathies. Modulating self-assembly process inhibiting formation such toxic promising strategies for therapy development. A challenge in investigating vitro is that, unlike most amyloidogenic proteins, does not aggregate absence posttranslational...
Abstract The role of epithelial membrane protein 1 (EMP1) in tumor microenvironment (TME) remodeling has not yet been elucidated. In addition, the biological function EMP1 triple-negative breast cancer (TNBC) is largely unclear. this study, we examined infiltration landscape cell types TME cancer, and found that expression was positively correlated with stromal microenvironmental scores. Infiltration analysis immunohistochemical (IHC) staining serial sections confirmed critical...
A targeted heptasaccharide library was synthesised to prepare a heparan sulphate (HS) microarray. The array probed with two glycan-binding proteins, HS 3-O-sulphotransferase 1 and antithrombin, demonstrating the binding selectivity between proteins. microarray technique will accelerate understanding of structure function relationships HS.
Neural stem cells and progenitor (NPCs) are increasingly appreciated to hold great promise for regenerative medicine treat CNS injuries neurodegenerative diseases. However, evidence effective stimulation of neuronal production from endogenous or transplanted NPCs neuron replacement with small molecules remains limited. To identify novel chemical entities/targets neurogenesis, we had established a NPC phenotypic screen assay validated it using known small-molecule neurogenesis inducers....
Apolipoprotein E (ApoE)'s ϵ4 alle is the most important genetic risk factor for late onset Alzheimer's Disease (AD). Cell-surface heparan sulfate (HS) a cofactor ApoE/LRP1 interaction and prion-like spread of tau pathology between cells. 3-O-sulfo (3-O-S) modification HS has been linked to AD through its with tau, enhanced levels 3-O-sulfated 3-O-sulfotransferases in brain. In this study, we characterized ApoE/HS interactions wildtype ApoE3, AD-linked ApoE4, AD-protective ApoE2...
Background Hand-foot-and-mouth disease_(HFMD) is one of the most typical diseases in children that associated with high morbidity. Reliable forecasting crucial for prevention and control. Recently, hybrid models have become popular, wavelet analysis has been widely performed. Better prediction accuracy may be achieved using wavelet-based models. Thus, our aim to forecast number HFMD cases Materials methods We fitted a seasonal autoregressive integrated moving average (SARIMA)–neural network...
Tree peony is a traditional famous flower of China, and plays an important role in Chinese culture. But the floral scent tree vivo little known. In this study, order to explore composition peony, volatiles six cultivars, including Paeonia suffruticosa 'Zhaofen' (ZF), P. 'Luoyanghong' (LYH), ostii 'Fengdanbai' (FDB), <TEX>${\times}$</TEX> lemonei 'High noon' (HN), 'Renown' (R), rockii 'Gaoyuanshenghuo' (GYSH) were collected by dynamic headspace then identified Automated Thermal Desorption-Gas...
Identification of novel chemotherapeutic agents from traditional medicines and elucidation the molecular basis their anticancer effects are critical urgently needed for modern pharmacotherapy. We previously found that analogs compounds present in Valeriana jatamansi, a medicine used to treat mental disorders, possess notable antitumor properties; however, underlying mechanisms have not been fully demonstrated. In this study, we evaluated IVHD-valtrate, one most active jatamansi derivatives,...
Langerin, a C-type lectin, is expressed in Langerhans cells. It was reported that langerin binds sulfated glycans, which an important initial step for its role blocking human immunodeficiency virus (HIV) transmission by capturing HIV pathogens and mediating their internalization into Birbeck granules elimination. fundamentally to understand these interactions at the molecular level design of new highly specific therapeutic agents HIV. Surface plasmon resonance (SPR), allows real-time,...