A5029219785- Glioma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Alcohol Consumption and Health Effects
- Nutritional Studies and Diet
- Cancer, Hypoxia, and Metabolism
- Gout, Hyperuricemia, Uric Acid
- Metabolomics and Mass Spectrometry Studies
- Tryptophan and brain disorders
- Mitochondrial Function and Pathology
- Cardiac Health and Mental Health
- Radiomics and Machine Learning in Medical Imaging
- Immune cells in cancer
- Diabetes Management and Education
- Circadian rhythm and melatonin
- Redox biology and oxidative stress
- Air Quality and Health Impacts
- MicroRNA in disease regulation
- Climate Change and Health Impacts
- Diet and metabolism studies
- Cancer Genomics and Diagnostics
- Hepatitis Viruses Studies and Epidemiology
Yunnan Provincial Department of Education
2025
Kunming Medical University
2015-2024
Beijing Institute of Neurosurgery
2019-2021
Capital Medical University
2019-2021
Beijing Tian Tan Hospital
2020
Kunming Institute of Zoology
2011-2015
Guangzhou University of Chinese Medicine
2015
University of Chinese Academy of Sciences
2013
Chinese Academy of Sciences
2013
Kunming University of Science and Technology
2009-2012
•Epidemiologic evidence on the potential role of ambient air pollution in MAFLD is limited.•This study found significant positive associations between and odds MAFLD.•Unhealthy lifestyle habits presence central obesity may exacerbate harmful effects.•This large-scale human provides robust results calls for more prospective studies. Background & AimsAccumulating animal studies have demonstrated contribution (AP) to metabolic dysfunction-associated fatty liver disease (MAFLD), but...
Health-related quality of life is a multi-dimensional concept that involves individual's perceived physical and mental health, social relationships, environment. Family members are the primary caregivers people living with schizophrenia in China, caregiver generally poorer, which may indirectly affect schizophrenia. We conducted comprehensive survey on based Schizophrenia-specific cohort Less-developed Multi-ethnic Region Southwest China to validate accessibility effectiveness family care...
Drug addiction is a chronic brain disease that serious social problem and causes enormous financial burden. Because mitochondrial abnormalities have been associated with opiate addiction, we examined the effect of morphine on mtDNA levels in rat mouse models cultured cells. We found copy number was significantly reduced hippocampus peripheral blood morphine-addicted rats mice compared control animals. Concordantly, decreased elevated damage were observed from opiate-addicted patients,...
Autophagy is involved in the pathogenesis of neurodegenerative diseases including Parkinson disease (PD). However, little known about regulation autophagy process. In this study, we characterized aberrant activation induced by neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) and demonstrated that melatonin has a protective effect on neurotoxicity. We found an excessive monkey brain tissues C6 cells, MPTP, which mediated CDK5 (cyclin-dependent kinase 5). MPTP treatment...
GB virus C (GBV-C) is prevalent globally and particularly among individuals at risk of parental exposures. Based on genetic diversity, this now classified into six genotypes many subtypes with distinct geographical distribution. In study, 120 Injecting Drug Users (IDUs) were recruited from Yunnan province, China. Among them, 43 (35.8%) positive for GBV-C RNA, 70 (58.3%) 103 (85.8%) sero-positive HIV-1 HCV respectively. This revealed 18.3% IDUs having GBV-C/HIV/HCV triple infection, which...
Isocitrate dehydrogenase (IDH) wild-type diffuse lower-grade glioma (LGG) is usually associated with poor outcome, but there have been disputes over its clinical outcome and classification. We present here a robust gene expression-based molecular classification of IDH LGG into two subtypes distinct biological features. A discovery cohort 49 LGGs from the Chinese Glioma Genome Atlas (CGGA) was subjected to clustering function analysis. Seventy-three tumors The Cancer (TCGA) were used validate...
Transcriptomic data derived from bulk sequencing have been applied to delineate the tumor microenvironment (TME) and define immune subtypes in various cancers, which may facilitate design of immunotherapy treatment strategies. We herein gathered published gene expression diffuse lower-grade glioma (LGG) patients identify subtypes. Based on profiles 402 LGG The Cancer Genome Atlas, we performed consensus clustering determine robust clusters patients, evaluated their reproducibility three...
Glioblastoma is one of the most common neoplasms in central nervous system characterized by limited immune response and unlimited expansion capability. Cancer stem cells (GSCs), a small fraction tumor cells, possess pivotal regulation capability microenvironment with superior proliferation ability. We aimed to reveal interaction between glioma (GSCs) during tumorigenesis. Single-cell sequencing data from seven surgical specimens glioblastoma patients patient-derived GSCs co-cultured...
While exercise has been shown to reduce the negative effects of substance withdrawal symptoms, no research investigated if Tai Chi, a traditional Chinese exercise, similar effects. Here, we observed physiological Chi on protracted abstinence syndrome (PAS) in female heroin addicts by comprehensively inspecting their immune system function, complete blood count, hepatic function and renal function. To determine psychological effects, used Hamilton Rating Scale for Depression (HRSD) rating...
The tree shrew (Tupaia belangeri chinensis), a small animal widely distributed in Southeast Asia and southwest China, has the potential to be developed as an model for hepatitis C. To determine susceptibility of C virus (HCV) infection vitro vivo, well-established HCV, produced from J6/JFH1-Huh7.5.1 culture system, was used infect cultured primary tupaia hepatocytes (PTHs) shrews. results showed that HCV genomic RNA HCV-specific nonstructural protein 5A (NS5A) could detected PTH cell days...
Abstract Aims We aimed to create a tumor recurrent‐based prediction model predict recurrence and survival in patients with low‐grade glioma. Methods This study enrolled 291 (188 the training group 103 validation group) clinicopathological information transcriptome sequencing data. LASSO‐COX algorithm was applied shrink predictive factor size build recurrent signature. GO, KEGG, GSVA analyses were performed for function annotations of The calibration curves C‐Index assessed evaluate...
Glutaredoxin is central to cellular redox chemistry and regulates homeostasis malignant progression of many cancers. In glioma, the role its coding gene ( GLRX ) remains unclear. We aimed elucidate glutaredoxin at transcriptome level clinical prognostic value in glioma. total, we evaluated 1,717 glioma samples with data corresponding as well single-cell sequencing from 6 patients publicly available databases. Gene set variation analysis ontology were performed reveal biological function ....
Background: Inhibitors of immune checkpoints have shown little effect in clinical trials involving glioma patients. Here, we explored novel targets for use future treatments. Previous studies showed the sialic acid-binding Ig-like lectin (Siglec) family to a specific role immunosuppression. We aimed study characteristics and function Siglec members. Methods: Transcriptome data from 1024 samples 1551 single cells were used our study. Clinical molecular pathology information was also included....
To determine the association of physical activity (PA) and sedentary time (ST; leisure total ST), commuting mode with hyperuricemia in a multiethnic Chinese population, to analyze difference between sexes.Baseline data were analyzed from 22,094 participants China Multi-Ethnic Cohort study Yunnan region, China. PA behavior assessed through questionnaires. Hyperuricemia was defined as serum urate > 7.0 mg/dL among men 6.0 women. A restricted cubic spline (RCS) created model possible nonlinear...
Abstract Context Loss of sleep or disturbance sleep-wake cycles has been related to metabolic impairments. However, few studies have investigated the association between daily duration and hyperuricemia. Objective We (daytime napping nocturnal sleep) with hyperuricemia risk. Methods cross-sectionally analyzed data from China Multi-Ethnic Cohort (CMEC), Yunnan region. A total 22 038 participants aged 30 79 years were recruited in 2018. Hyperuricemia was defined as serum uric acid (SUA) above...
Previous studies in patients with hepatitis C virus (HCV)/HIV coinfection have shown that the presence of GBV-C is associated significantly less compensated and decompensated cirrhosis, an improvement cirrhosis-free survival.This study aimed to describe effect chronic HIV coinfection.We retrospectively studied 105 injecting drug users 72 HCV mono-infections. Plasma samples were tested for RNA primers 5'untranslated region gene. viral load, CD4(+) CD8(+) cell count, levels alanine...