A5100727094- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Retinal and Macular Surgery
- Plant Micronutrient Interactions and Effects
- Hepatitis B Virus Studies
- Glycosylation and Glycoproteins Research
- Apelin-related biomedical research
- Ferroptosis and cancer prognosis
- Hepatitis C virus research
- Retinal Diseases and Treatments
- Regional Development and Environment
- Medical Research and Treatments
- Glaucoma and retinal disorders
- Plant Stress Responses and Tolerance
- Nuclear Receptors and Signaling
- Plant nutrient uptake and metabolism
- Peptidase Inhibition and Analysis
- Metabolomics and Mass Spectrometry Studies
- Sulfur Compounds in Biology
- Cancer Mechanisms and Therapy
- Autophagy in Disease and Therapy
- Respiratory viral infections research
- Berberine and alkaloids research
China Pharmaceutical University
2021-2025
State Key Laboratory of Natural Medicine
2021-2024
Zhejiang Lab
2024
First People's Hospital of Yunnan Province
2015-2024
Affiliated Hospital of Southwest Medical University
2024
Yangtze Normal University
2024
Hebei Eye Hospital
2019-2024
Anhui University of Finance and Economics
2024
Capital Medical University
2024
Huazhong Agricultural University
2017-2023
Hepatocyte apoptosis, a well-defined form of cell death in non-alcoholic steatohepatitis (NASH), is considered the primary cause liver inflammation and fibrosis. However, mechanisms underlying regulation hepatocyte apoptosis NASH remain largely unclear. We explored anti-apoptotic effect CD1d NASH.
Abstract Background Accumulating evidence shows that mesenchymal stem cells (MSCs) have the potential as a cellular therapy avenue for schistosome-induced liver injury. Extracellular vesicles (EVs) are membranous released by almost all cell types, and EVs produced MSCs (MSC-EVs) exert therapeutic effects in several disease models. However, of MSC-EVs schistosomiasis treatment remains unclear. Methods Using survival analysis, HE Masson’s trichrome staining, immunohistochemical, western blot...
The coexistence of ferroptosis and other modes death has great advantages in the treatment cancers. A series glutathione peroxidase 4 (GPX4) cyclin-dependent kinase (CDK) dual inhibitors were designed synthesized, given synergistic anticancer effect ML162 (GPX4 inhibitor) combination with indirubin-3′-oxime (IO) (CDK inhibitor). Compound B9 exhibited highest potential cytotoxic activity against all four cell lines displayed excellent inhibitory GPX4 (IC50 = 542.5 ± 0.9 nM) selective...
To investigate the effects of Genistein on osteogenic related gene expression profiles during osteoblastic differentiation human bone marrow mesenchymal stem cell (hBMSC) cultures, hBMSCs were cultured under medium with addition (10(-8)∼10(-5) M) for 12 days. The proliferation was measured by BrdU incorporation, while in hBMSC cultures assessed cellular alkaline phosphatase (ALP) activity. apoptosis determined caspase 3/7 activation. GEArray Q series osteogenesis array used to analyze...
To investigate the pharmacokinetics and pharmacodynamics of a dual-acting glucokinase activator, dorzagliatin, its safety, tolerability effect on pancreatic β-cell function in Chinese patients with type 2 diabetes (T2D).A total 24 T2D were selected, utilizing set predefined clinical biomarkers, randomized to receive dorzagliatin 75 mg twice or once daily (BID, QD respectively) for 28 days. Changes HbA1c glycaemic parameters from baseline Day assessed. In addition, changes 32...
Adenomyosis (AM) is a common benign uterine disorder that has deleterious effects on women's health. However, the pathogenesis of AM not clearly understood. We aimed to investigate pathophysiological changes and molecular mechanism in AM.Single-cell RNA sequencing (scRNA-seq) was employed construct transcriptomic atlas various cell subsets from ectopic endometrium (EC) eutopic (EM) one patient evaluate differential expression. The Cell Ranger software pipeline (version 4.0.0) applied conduct...
Avian coccidiosis is an intracellular intestinal parasitic disease, caused by parasites from the genus Eimeria, among which Eimeria tenella one of most pathogenic species and causes great economic losses. Frequent applications anticoccidial drugs have resulted in development drug-resistance E. tenella. In present study, we sought to determine genetic diversity isolates prevalent chicken farms Hubei Province China examine their sensitivity three drugs. The results provide useful information...
A novel visible-light-induced radical cascade bromocyclization of N-arylacrylamides has been accomplished. This reaction overcomes the overbromination at benzene rings suffered in traditional electrophilic reactions, thus enabling first highly chemoselective synthesis valuable 3-bromomethyloxindoles. The combination pyridine and anhydrous medium is identified as key factor for high chemoselectivity current photoreaction system, which might work by suppressing situ generation...
This paper qualitatively analyses China’s commercial pension insurance system from an international comparative angle, identifying issues such as insufficient tax incentives, product homogeneity, and a lack of policy coordination. On the basis experiences U.S. market-led Japan’s government–market synergy, “optimisation framework” “strong broad coverage, innovation” is constructed. Specifically, it proposes optimising incentive system, innovating products services, strengthening synergies,...
Apelin signaling to the family of mitogen-activated protein kinases (MAPKs), such as extracellular-regulated 1/2 (ERK1/2) and p38 MAPK, through coupling apelin receptor (APJ) G-protein, mediates important pathophysiological responses. Although fragments have been reported induce ERK1/2 activation Gi-protein, intracellular pathways by which APJ activates these MAPKs are only partially understood. Here, using stably transfected human embryonic kidney 293 (HEK293) cells overexpressing...
Abstract Due to the non-uniform distribution of inorganic phosphate (Pi) in soil, plants modify their root architecture improve acquisition this nutrient. In study, a split-root system was employed assess nature local and systemic signals that modulate Brassica napus grown with Pi availability. Lateral (LR) growth regulated systemically by distribution, increasing second-order LR (2°LR) density compartments high supply but decreasing it low Transcriptomic profiling identified groups genes...
Abstract Background Acute ischemic stroke (AIS) complicating an acute myocardial infarction (AMI) is not uncommon, but can severely worsen the clinical prognosis. This study aimed to investigate whether remote conditioning (RIC) could provide benefits patients with AIS AMI. Methods Subjects AMI were recruited in this double-blind, randomized, controlled trial; assigned RIC and sham groups; respectively underwent twice daily for 2 weeks. All subjects received standard medical therapy. The...
1. Clopidogrel is one of the most important antithrombotic drugs but has different efficacies in populations. The aim present study was to evaluate contribution CYP2C19 genetic polymorphisms inhibition ADP-induced platelet aggregation by clopidogrel healthy Chinese volunteers. 2. Eighteen male volunteers (six CYP2C19*1/CYP2C19*1, six CYP2C19*1/CYP2C19*2and*3 and CYP2C19*2/CYP2C19*2and*3) were enrolled study. Each subject took 300 mg on first day then 75 once daily for 2 consecutive days....
Activated hepatic stellate cells (HSCs) are the crucial factor responsible for liver fibrosis and involved in development of hepatocellular carcinoma (HCC) by interaction with tumour cells. Newcastle disease virus (NDV) has oncolytic characteristics intrinsically selective replication neoplasia transformed But, NDV HSCs effects on have not been reported.We detected effect conditioned medium (CM) from human HCC activation HSC line, LX-2 a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium...