A5056843658- Extracellular vesicles in disease
- Lung Cancer Treatments and Mutations
- Parasites and Host Interactions
- Lung Cancer Research Studies
- MicroRNA in disease regulation
- Macrophage Migration Inhibitory Factor
- Lung Cancer Diagnosis and Treatment
- Nerve injury and regeneration
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Neonatal Respiratory Health Research
- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
- RNA Interference and Gene Delivery
- Mesenchymal stem cell research
- Inflammasome and immune disorders
- Inflammation biomarkers and pathways
- Eicosanoids and Hypertension Pharmacology
- Bioactive natural compounds
- Epigenetics and DNA Methylation
- Parasite Biology and Host Interactions
- Studies on Chitinases and Chitosanases
- IL-33, ST2, and ILC Pathways
- Infant Nutrition and Health
- Immune Response and Inflammation
Jiangsu University
2017-2025
Jintan People's Hospital
2017-2025
Affiliated Hospital of Jiangsu University
2019-2025
Betta Pharmaceuticals (China)
2018-2024
Nanjing Medical University
2020-2021
BeiGene (China)
2021
First Affiliated Hospital of Chinese PLA General Hospital
2020
Sir Run Run Shaw Hospital
2020
Zhejiang University
2020
Abstract Background As one of the main functional forms mesenchymal stem cells (MSCs), MSC-derived extracellular vesicles (MSC-EVs) have shown an alternative therapeutic option in experimental models allergic asthma. Oxygen concentration plays important role self-renewal, proliferation, and EV release MSCs a recent study found that anti-asthma effect was enhanced by culture hypoxic conditions. However, potential EVs (Hypo-EVs) asthma is still unknown. Methods BALB/c female mice were...
Abstract Peripheral nerve injury results in limited regeneration and severe functional impairment. Mesenchymal stem cells (MSCs) are a remarkable tool for peripheral regeneration. The involvement of human umbilical cord MSC‐derived extracellular vesicles (hUCMSC‐EVs) regeneration, however, remains unknown. In this study, we evaluated recovery rats that received hUCMSC‐EV treatment after transection. We observed promoted the motor function axons; increased sciatic index; resulted generation...
Asthma is a prevalent respiratory disease, and its management remains largely unsatisfactory. Mesenchymal stem cells (MSCs) have been demonstrated to be efficacious in reducing airway inflammation experimental allergic diseases, representing potential alternative treatment for asthma. Migrasomes are recently identified extracellular vesicles (EVs) generated migrating facilitate intercellular communication. The objective of this study was investigate the therapeutic effects migrasomes...
Abstract Background Accumulating evidence shows that mesenchymal stem cells (MSCs) have the potential as a cellular therapy avenue for schistosome-induced liver injury. Extracellular vesicles (EVs) are membranous released by almost all cell types, and EVs produced MSCs (MSC-EVs) exert therapeutic effects in several disease models. However, of MSC-EVs schistosomiasis treatment remains unclear. Methods Using survival analysis, HE Masson’s trichrome staining, immunohistochemical, western blot...
Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are extremely promising nanoscale cell-free therapeutic agents. We previously identified that intravenous administration (IV) of human umbilical cord MSC-EVs (hUCMSC-EVs), especially hypoxic hUCMSC-EVs (Hypo-EVs), could suppress allergic airway inflammation and remodeling. Here, we further investigated the effects Hypo-EVs by atomizing inhalation (INH), which is a non-invasive efficient drug delivery method for lung diseases....
Migrasomes comprise a recently identified unique type of extracellular vesicle (EV) containing varying numbers small vesicles. However, the final fate these vesicles is still unclear. Here, we report discovery EV‐like migrasome‐derived nanoparticles (MDNPs) that are produced by migrasomes releasing internal via self‐rupture and through process similar to cell plasma membrane budding. Our results demonstrate MDNPs have structure with typical round‐shaped morphology characteristic markers...
Osteoarthritis (OA) constitutes a widespread degenerative joint disease predominantly affecting the elderly, leading to disability. There is still lack of biomarkers for OA, so it cannot be intervened in time. OA were identified from human cartilage datasets using LASSO and SVM-RFE, followed by ROC analysis. LOXL1 was prioritized further research due its high expression robust predictive performance. Anterior cruciate ligament transection (ACLT) surgery-induced rats used explore correlation...
Accumulation of advanced glycation end products (AGEs) and endothelial dysfunction are major factors that contribute to the progression vascular complications in diabetes. Migrasomes, a newly discovered organelle involved mitocytosis, play an important role selective removal damaged mitochondria. Our research shows human umbilical vein cells (HUVECs) can release migrasomes undergo mitocytosis. In addition, when exposed oxidative stress from AGEs, mitochondrial damage worsens, leading...
Abstract Helminths and their products can shape immune responses by modulating cells, which are dysfunctional in inflammatory diseases such as asthma. We previously identified SJMHE1, a small molecule peptide from the HSP60 protein of Schistosoma japonicum . SJMHE1 inhibit delayed‐type hypersensitivity collagen‐induced arthritis mice. In present study, we evaluated this peptide's potential intervention effect mechanism on ovalbumin‐induced asthma treatment suppressed airway inflammation...
Harnessing helminth-based immunoregulation is a novel therapeutic strategy for many immune dysfunction disorders, including inflammatory bowel diseases (IBDs). We previously identified small molecule peptide from Schistosoma japonicum and named it SJMHE1. SJMHE1 can suppress delayed-type hypersensitivity, collagen-induced arthritis asthma in mice. In this study, we assessed the effects of on dextran sulfate sodium (DSS)-induced acute chronic colitis.Acute colitis were induced C57BL/6 mice by...
Peripheral nerve injury and regeneration are complex processes involve multiple molecular signalling components. However, the involvement of long non-coding RNA (lncRNA) in this process is not fully clarified. In study, we evaluated expression lncRNA maternally expressed gene 3 (MEG3) rats after sciatic transection explored its potential mechanisms. The MEG3 was up-regulated following observed Schwann cells (SCs). down-regulation SCs enhanced proliferation migration via PTEN/PI3K/AKT...
Asthma is a complex and heterogeneous inflammatory response characterized by various immune cells, including myeloid-derived suppressor cells (MDSCs) CD4 + T-cell subsets.However, few studies on MDSC subsets the association between MDSCs in asthma are reported.In present study, we detected T evaluated relationship of these mice with ovalbumin-induced asthma.We found that asthmatic showed severe airway cell infiltration lungs bronchoalveolar lavage fluid.We also noted increased numbers Th2,...
Abstract Background There are controversial data supporting the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with advanced lung squamous cell carcinoma (SCC). In this study, icotinib unselected and EGFR ‐mutated SCC was assessed. Methods We retrospectively analyzed survival time treated for at least 5 months between June 2013 2016, selected appropriate EGFR‐ mutated ADC to have 1:1 ratio propensity score matching patients, factors were...
Introduction: Esophageal-Squamous Cell Carcinoma (ESCC) is often diagnosed at the middle or late stage, thus requiring more effective therapeutic strategies. Pharmacologically, anti-tumor activity of principal active constituent Sophora flavescens, matrine (MA), has been explored widely. Notwithstanding, it significant to nanotechnologically enhance MA in view its potential distribute non-tumor cells. Methods: Herein, MA-loaded Nano-Liposomes (MNLs) were prepared effect anti-ESCC. The MNL...
The role of platelet to mean volume ratio in the identification adult-onset still's disease from sepsis Suohua Ge 0 -0 , I,# Yongbin Ma Mengxiao Xie II,# Tengfei Qiao -
Lung cancer is a global health problem with high mortality, and the development of target therapy has led to revolution in treatment lung recent years. Favorable efficacy safety icotinib have been demonstrated patients non-small cell (NSCLC). Currently, minimal data are available describe long-term NSCLC patients.We reviewed from 1,321 advanced who were treated icotinib. The primary endpoint was safety, defined as any adverse drug reactions (ADRs) occurred after 6 months administration.Fewer...
The pathogenesis of infective endocarditis (IE) is a complex process which can include tissue damage to the valves during bacteraemia, pathogen adherence leading formation non-bacterial thrombotic vegetations, platelet aggregation at sites damage, and variety biological interactions between pathogens host matrix molecules (e.g. platelets).1,2 In past few decades, incidence IE has increased significantly, may be result an aging population, delayed diagnosis valvular heart disease, even new...
The effect of icotinib on non-small cell lung cancer (NSCLC) patients with EGFR exon 19 deletions (19-Del) or L858R point mutation in 21 (21-L858R) remains inconsistent. This study aimed to evaluate the efficacy and safety advanced NSCLC harboring these 2 mutations.We retrospectively assessed clinical effects first-line classic mutations. Kinase activity assays were used reaffirm preclinical efficacy.Among 2,757 patients, 2,365 (86%) harbored 19-Del (1,346/2,757, 49%) 21-L858R (1,019/2,757,...
Abstract Aim To report the efficacy and safety of ensartinib, an anaplastic lymphoma kinase (ALK) inhibitor, in treating patients with ALK‐positive advanced lung squamous cell carcinoma (LUSC) or adenosquamous (LASC) China. Methods This retrospective study analyzed data for 36 advanced‐stage LUSC (cohort A) 13 LASC B) between December 16, 2020 2021. All received once‐daily ensartinib 225 mg. Outcome analysis included demographic characteristics, tumor response, progression‐free survival...