A5101828196- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Pancreatitis Pathology and Treatment
- Protein purification and stability
- Monoclonal and Polyclonal Antibodies Research
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- Neurogenesis and neuroplasticity mechanisms
- S100 Proteins and Annexins
- Metabolism, Diabetes, and Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Speech and dialogue systems
- Nerve injury and regeneration
- Esophageal Cancer Research and Treatment
- Chronic Lymphocytic Leukemia Research
- Alzheimer's disease research and treatments
- Circular RNAs in diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Cholesterol and Lipid Metabolism
- Autophagy in Disease and Therapy
- Embedded Systems and FPGA Design
- Heat transfer and supercritical fluids
- Ion channel regulation and function
Sichuan University
2024
Wuxi No.2 People's Hospital
2017-2024
Jiangsu University
2015-2023
Jintan People's Hospital
2015-2023
Astellas Pharma (United States)
2023
Shenyang Pharmaceutical University
2022
Huahai Pharmaceutical (China)
2019
Nanjing Medical University
2009-2018
Jiangsu Province Hospital
2009-2018
Guangdong General Hospital
2015
Re-programming of lipogenic signaling has been previously demonstrated to result in significant alterations tumor cell pathology. Sterol regulatory element-binding protein 1 (SREBP-1) is a known transcription factor genes. Despite the fact that its functions proliferation and apoptosis have elucidated recent studies, role migration invasion, particularly breast cancer, remains unclear. In present study, messenger RNA expression levels SREBP-1 cancer tissues were observed be overexpressed...
Abstract Peripheral nerve injury results in limited regeneration and severe functional impairment. Mesenchymal stem cells (MSCs) are a remarkable tool for peripheral regeneration. The involvement of human umbilical cord MSC‐derived extracellular vesicles (hUCMSC‐EVs) regeneration, however, remains unknown. In this study, we evaluated recovery rats that received hUCMSC‐EV treatment after transection. We observed promoted the motor function axons; increased sciatic index; resulted generation...
Alzheimer's disease (AD) is a neurodegenerative disorder, and the most common type of dementia in elderly population.Growing evidence indicates that microRNAs (miRNAs) play crucial role neuroinflammation associated with AD progression.In this study, we analyzed expression microRNA-139 (miR-139) as well learning memory function AD.We observed miR-139 was significantly higher hippocampus aged senescence accelerated mouse prone 8 (SAMP8) mice (2.92 ± 0.13) than control (1.49 0.08).Likewise,...
Brain damage following cerebral ischemia-reperfusion (I/R) is a complicated pathophysiological course, in which inflammation and oxidative stress have been suggested to serve an important role. Toll‑like receptor 4 (TLR4) has be involved secondary inflammatory process ischemia. Nuclear factor erythroid 2-related 2 (Nrf2), regulator of the antioxidant host defense, maintains cellular redox homeostasis. Tissue kallikrein (TK) proven elicit variety biological effects ischemic stroke through its...
As an alternative mesenchymal stem cell- (MSC-) based therapy, MSC-derived extracellular vesicles (EVs) have shown promise in the field of regenerative medicine. We previously found that human umbilical cord cell-derived EVs (hUCMSC-EVs) improved functional recovery and nerve regeneration a rat model sciatic transection. However, underlying mechanisms are poorly understood. Here, we demonstrated for first time hUCMSC-EVs promoted proliferation Schwann cells by activating PI3K/AKT signaling...
Abstract This research aimed to determine the relationships between risk factors for nosocomial multidrug-resistant Acinetobacter baumannii (MDRAB) bacteremia and associated mortality. We analyzed 144 patients treated A. bacteremia, including 120 with MDRAB from March 2015 2020, in this retrospective study. The overall bacteremia-related mortality rate was 48.6%. rates were 25.0% 53.3% non-MDRAB respectively. Risk development of prior use cephalosporins [odds ratio (OR): 8.62; P <...
BACKGROUND Gremlin has been reported to be up-regulated in glomerular mesangial cells diabetic nephropathy (DN). However, the regulation of gremlin podocytes is still rarely reported. This study aimed investigate underlying mechanisms by which mediates pathogenesis DN via transforming growth factor-β (TGF-β) signaling pathways. MATERIAL AND METHODS Lentiviral and RNAi transfection were performed increase decrease expression high-glucose conditions. Expression at mRNA protein level was...
Background: Vasoactive drug alprostadil improves microcirculation and can be effective in treating disorders of peripheral nerves. Vascular endothelial growth factor (VEGF) has been shown to have protective action cerebral ischemia, spinal cord, also However, the mechanism VEGF nerve injuries is uncertain. Objectives: To study effect application on pathological functional repair crush expression VEGF. Materials Methods: Rat sciatic nerves were crushed by pincers establish model injury. All...
Objective. To determine serum glucose-6-phosphate isomerase (GPI) concentrations in patients with rheumatoid arthritis (RA), and to test whether they correlate objective measures of disease activity. Methods. Sera from 116 RA, 69 non-RA rheumatic diseases, 101 healthy controls were analyzed. Levels soluble GPI measured by ELISA. Histological activity was determined the synovitis score synovial needle biopsies 58 RA. Thirty-one synovium samples stained for CD68, CD3, CD20, CD38, CD79a, CD34...
Background: Still considered one of the most prevalent nutritional problems in world, anemia has been shown many studies to have deleterious effects on neurobehavioral development. While research efforts focused investigating social and emotional development infants by using a cross-sectional design, is still needed investigate whether early childhood anemia, beyond infantile years, linked with behavioral problems. Objective: This study assessed (1) hemoglobin (Hb) levels are associated...
This paper analyzes the advantages and disadvantages of traditional HDFS cluster architecture. An application framework designed for small medium-sized clusters is proposed in this to make up incomplete architecture, difficulties on deploying, inefficiency I/O processing files. In addition, a caching mechanism added optimize operation system Experiments show that plan feasible increased disk cache can significantly improve efficiency files system.
ABSTRACT FTY720 is a sphingosine 1 phosphate (S1P) receptor agonist approved for the treatment of multiple sclerosis, which chronic inflammatory autoimmune disorder. Sepsis complex syndrome associated with progressive endotoxemic developments, finally leads to damage organs, including heart. In critical patients, cardiovascular dysfunction due sepsis major cause death. Previous studies have shown an association between S1P and cardioprotection in situation ischemia reperfusion myocardial...