Ischemic stroke, accounting for 85% of stroke cases, leads to severe disabilities and increased mortality. Its global incidence rose by 87.55% from 1990 2019, posing significant health economic burdens. The BRICS-plus nations-Brazil, Russia, India, China, South Africa, five others-represent a large population, presenting unique public challenges. This study aims evaluate the epidemiological trends variations in burden ischemic across nations timely manner. Data on number, all-age rate,...

<h3>Background</h3> Prevalences of Alzheimer disease (AD) and vascular dementia (VaD) in China reportedly differ from those Western countries. <h3>Objective</h3> To estimate prevalence AD VaD 4 regions China. <h3>Design</h3> Cross-sectional, population-based survey with a stratified, multistage cluster sampling design. <h3>Setting</h3> Rural (n = 99) urbanized 71) communities Beijing, Xian, Shanghai, Chengdu. <h3>Participants</h3> A sample 34 807 community residents (94% eligible) 55 years...

Repairing infected bone defects relies on a scaffold that can not only fill the to promote formation but also kill clinically present bacterial pathogens such as Staphylococcus aureus (S. aureus). To meet this demand, here, we develop new copper (Cu) containing natural polymeric with full potential for repairing defects. Instead of directly adding antibacterial Cu2+ ions polymer mixtures, which caused uncontrolled cross-linking, added Cu nanoparticles mixture anionic carboxymethyl chitosan...

The antibacterial mechanism of the Cu‐containing materials has not been fully understood although such understanding is crucial for sustained clinical use as bone implants. aim this study to investigate molecular mechanisms by which Gram‐positive Staphylococcus aureus inactivated through Cu‐bearing titanium alloys (Ti6Al4V5Cu). Cu ions released from are found contribute lethal damage bacteria. They destroy permeability bacterial membranes, resulting in leakage reducing sugars and proteins...

Abstract A theranostic platform combining synergistic therapy and real‐time imaging attracts enormous attention but still faces great challenges, such as tedious modifications lack of efficient accumulation in tumor. Here, a novel type agent, bismuth sulfide@mesoporous silica (Bi 2 S 3 @mPS) core‐shell nanoparticles (NPs), for targeted image‐guided human epidermal growth factor receptor‐2 (HER‐2) positive breast cancer is developed. To generate NPs, polyvinylpyrrolidone decorated rod‐like Bi...

Abstract Rheumatoid arthritis (RA) is a worldwide inflammatory disease that seriously threatens human health and needs more effective treatment approaches. Near infrared (NIR) light can efficiently penetrate inflamed joints affected by RA, so phototherapy, including photothermal therapy (PTT) photodynamic (PDT), may provide new opportunities. In this work, the unique Cu 7.2 S 4 nanoparticles (NPs) are prepared for RA enlightened fact copper (Cu)‐based nanomaterials simultaneously serve as...

Abstract Despite its 5‐year event‐free survival rate increasing to 60–65% due surgery and chemotherapy, osteosarcoma (OS) remains one of the most threatening malignant human tumors, especially in young patients. Therefore, a new approach that combines early diagnosis with efficient tumor eradication bioimaging is urgently needed. Here, type mesoporous silica–coated bismuth sulfide nanoparticles (Bi 2 S 3 @MSN NPs) developed. The well distributed pores large surface areas hold great promise...

Abstract Osteosarcoma resection is challenging due to the variable location of tumors and their proximity with surrounding tissues. It also carries a high risk postoperative complications. To overcome challenge in precise osteosarcoma resection, computer-aided design (CAD) was used patient-specific guiding templates for on basis computer tomography (CT) scan magnetic resonance imaging (MRI) human patients. Then 3D printing technique fabricate templates. The were guide surgery, leading more...

Abstract Toll-like receptor 9 (TLR9) senses bacterial DNA characteristic of unmethylated CpG motifs to induce innate immune response. TLR9 is de novo expressed in podocytes some patients with glomerular diseases, but its role podocyte injury remains undetermined. Since activates p38 MAPK and NFkB that are known mediate apoptosis, we hypothesized induces apoptosis diseases. We treated immortalized puromycin aminonucleosides (PAN) observed accompanied by upregulation. Prevention upregulation...

In the present work, bulk and homogeneous composite hydrogels were successfully constructed from positively charged chitosan (CS) negatively carrageenan (CG) in alkali/urea aqueous solution via a simple one-step approach for first time. An electroneutral CS was achieved alkali/urea, leading to blended by CG, which could not be realized acidic medium because of agglomeration caused polycation polyanion. Subsequently, CS/CG with multiple cross-linked networks prepared blend using...

Zero-dimensional carbon dots (CD) and their effects on osteogenesis have been rarely studied in bone repair scaffolds. Here, we fabricate a novel CD doped chitosan/nanohydroxyapatite (CS/nHA/CD) scaffold with full potential to promote regeneration by facile freeze-drying method. The CS/nHA/CD scaffolds enhanced cell adhesion osteoinductivity rat mesenchymal stem cells up-regulating genes involved focal vitro, which significantly improved the formation of vascularized new tissue at 4 weeks...

Abstract The influence of Mg-1Ca-xwt.% Sr (x = 0.2, 0.5, 1.0, 2.0) alloys on the osteogenic differentiation and mineralization pre-osteoblast MC3T3-E1 were studied through typical markers, such as intracellular alkaline phosphatase (ALP) activity, extracellular collagen secretion calcium nodule formation. It was shown that Mg-1Ca with different content promoted cell viability enhanced levels osteoblasts Mg-1Ca-2.0Sr alloy had most remarkable significant effect among all. To further...

&lt;i&gt;Objective:&lt;/i&gt; To characterize sociodemographic variations in the prevalence of AD and VaD China. &lt;i&gt;Methods:&lt;/i&gt; Data were collected a 1997–1998, cross-sectional, door-to-door survey 34,807 community residents ages ≧55 years Beijing, Shanghai, Chengdu Xian. Initial diagnoses assessed by clinicians using standardized protocols, according to NINCDS-ADRDA NINDS-AIREN criteria; confirmed after 6 months repeating neuropsychological evaluations. Prevalence odds ratios...

In Brief Study Design. vitro biomechanical study. Objective. To compare the pullout strengths and stabilities afforded by C1 lateral mass screws pedicle using bicortical unicortical fixation techniques. Summary of Background Data. Posterior screw techniques in atlas including screw. The shortcomings technique potential risks method were recently described; with might overcome these anatomic clinical drawbacks. However, it is unknown whether characteristics are comparable that Methods....

Biodegradable plastics are urgently needed in the biomedical field to avoid secondary surgery for implants after completing repair of nonload bearing bone defects. Herein, novel chitin based were successfully fabricated by changing shape and aggregation state structure hydrogels through drying under a negative pressure, which led plastic deformation. The prepared using an environmentally friendly aqueous NaOH/urea solvent, then radially oriented pressure form bioplastics (CP) on basis...

This study is conducted to investigate the biocompatibility and biodegradation behavior of calcium phosphate-coated Mg alloy in vivo. Calcium phosphate (Ca–P) was coated on (AZ31) by a chemical process. Samples Ca–P rods, naked degradable polymer as controls were implanted into thighbone rabbits bone response at early stage. The reduction implant volume determined micro-computed tomography three-dimensional reconstruction remaining segmented from matrix. It observed that rate faster than...

Microwave ablation has been widely accepted in treating bone tumor. However, its procedure is time-consuming and usually results postoperative fractures. To solve this problem, we designed fabricated titanium plates customized to the patients' structures. The personalized were then used for fixation after removal of tumorous tissue. Specifically, 3D models tumor-bearing segments constructed by using computed tomography (CT) magnetic resonance imaging (MRI). design plates. plate model was...

Implant-related bacterial infections are one of the most common but tricky problems in orthopedic clinics because formation biofilms inhibits penetration antibiotics to kill bacteria effectively; thus, a new strategy is urgently needed. Antibacterial nanomaterials [e.g., copper (Cu)-based nanoparticles (NPs)] combined with near-infrared (NIR) irradiation show enhanced antibacterial activity against clinical bacteria. However, their efficiency toward implant-related and biofilm remains...

Anatomic bony measurements were manually performed on 50 dry atlantoaxial vertebral complexes with an electronic digital caliper, and a reliable landmark for insertion of pedicle screw in C1 vertebra was described evaluated.To investigate the feasibility placing evaluate reliability C2 lateral mass as determining optimal site entry.The use C1-C2 screws additional rods or plates has been alternative method stabilization patients who are unsuitable transarticular stabilization. However, portal...

An anatomic study evaluating the feasibility of posterior screw fixation on lateral mass atlas and comparing pullout force C1 screws with that occipital C2 pedicle screws.To feasibility, anatomy, biomechanics within atlas.Occipitocervical fusion is a common choice for atlantoaxial dislocations. After movement occipitocervical region will be restricted. If could placed in atlas, 1) C0-C1 junction preserved; 2) through dislocated pulled backward; 3) fractured can fixed using directly.Thirty...

There is a dearth of literature on the incidence dementia in China.Using stratified, multistage, cluster-sampling method, 16,921 nondemented participants ≥55 years were recruited from four regional centers China 1997 and followed up to 4.5 years. Cases identified through three-step protocol, according standardized criteria for dementia, Alzheimer's (AD), vascular (VaD).The crude persons ≥65 was 12.1/1000 person-years 8.2/1000 AD, 3.1/1000 VaD. After adjusting sociodemographic factors, older...