A5100384771- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Sleep and Wakefulness Research
- Endoplasmic Reticulum Stress and Disease
- Ion channel regulation and function
- Effects and risks of endocrine disrupting chemicals
- Heme Oxygenase-1 and Carbon Monoxide
- Cardiac Imaging and Diagnostics
- Cellular transport and secretion
- Advanced Glycation End Products research
- Sleep and related disorders
- Neuroscience and Music Perception
- Alzheimer's disease research and treatments
- Cardiac Arrhythmias and Treatments
- Nerve injury and regeneration
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Paraquat toxicity studies and treatments
- Tryptophan and brain disorders
- Immune Response and Inflammation
- Thyroid Cancer Diagnosis and Treatment
- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
- Estrogen and related hormone effects
Nanjing Medical University
2016-2025
Jiangsu Province Hospital
2015-2025
Cangzhou Central Hospital
2025
Jiangnan University
2025
Anhui Polytechnic University
2024
Nanjing Drum Tower Hospital
2023
Sun Yat-sen University
2023
The First Affiliated Hospital, Sun Yat-sen University
2023
Second Affiliated Hospital of Nanjing Medical University
2021-2022
Jinan University
2021
Metastasis is the main cause of death in patients with advanced lung cancer. The exosomes released by cancer cells create tumor microenvironment, and then accelerate metastasis. Cancer-derived are considered to be driving force for metastasis niche formation at foreign sites, but mechanism Non-small cell carcinoma (NSCLC) unclear. In metastatic NSCLC patients, expression level miR-3157-3p circulating was significantly higher than that non-metastatic patients. Here, we found can transferred...
Abstract Chronic allograft dysfunction (CAD) induced by kidney interstitial fibrosis is the main cause of failure in transplantation. Endothelial‐to‐mesenchymal transition (EndMT) may play an important role fibrosis. We, therefore, undertook this study to characterize functions and potential mechanism EndMT transplant Proteins mRNAs associated with were examined human umbilical vein endothelial cells (HUVECs) treated transforming growth factor‐beta1 (TGF‐β1) at different doses or intervals...
Abstract Background Autophagic defects are involved in Methamphetamine (Meth)-induced neurotoxicity. Syntaxin 17 (Stx17), a member of the SNARE protein family, participating several stages autophagy, including autophagosome-late endosome/lysosome fusion. However, role Stx17 and potential mechanisms autophagic induced by Meth remain poorly understood. Methods To address mechanism Meth-induced cognitive impairment, adenovirus (AV) adeno-associated virus (AAV) were injected into hippocampus for...
Recent studies have revealed significant roles of neurotransmitters and gut microbiota along the gut–brain axis in Parkinson's disease (PD); however, potential mechanisms remain poorly understood. In current study, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced characteristic PD neurobehavior changes accompanied by increased α-synuclein, apoptotic protein Bim, cleaved caspase-3 decreased expression tyrosine hydroxylase (TH). Meanwhile, tryptophan (Trp) (Tyr) neurotransmitter...
Motivated by the potential of objective neurophysiological markers to index thalamocortical function in patients with severe psychiatric illnesses, we comprehensively characterized key non-rapid eye movement (NREM) sleep parameters across multiple domains, their interdependencies, and relationship waking event-related potentials symptom severity. In 72 schizophrenia (SCZ) 58 controls, confirmed a marked reduction spindle density SCZ extended these findings show that fast slow properties were...
Serum phosphate levels are strongly correlated with the prognosis of septic patients. However, previous studies have concentrated on individual levels, and relationship between change trends in serum in-hospital mortality has seldom been reported. We aimed to investigate whether level were associated mortality. classified patients using k-means clustering analysis into clusters changes used logistic regressions explore relationships different mortality, taking cluster smallest as a...
In addition to the high neurotoxicity, depression, and anxiety are most prominent characteristics of methamphetamine (Meth) withdrawal. Studies date on issue Meth-associated depression focused brain, however, whether peripheral homeostasis, especially "microbiota-gut" axis participates in these adverse outcomes, remains poorly understood. current study, with fecal microbiota transplantation (FMT) assay, mice received from Meth withdrawal displayed marked behaviors. The 16S rRNA sequencing...
Methamphetamine (Meth) is a potent psychoactive stimulant that triggers complex neurotoxicity characterized by autophagy-associated neuronal death. However, the potential mechanisms remain poorly understood. This study aimed to decipher Meth-induced necroptosis involving mitochondrial defect-initiated excessive mitophagy caused aberrant presenilin-associated rhomboid-like (PARL) cleavage of PTEN-induced kinase 1 (PINK1) and phosphoglycerate mutase family member 5 (PGAM5). With transcriptome...
Abstract This study aimed to investigate potential targets for the pathogenesis of atrial fibrillation facilitate development effective treatments. Atrial fibroblasts were isolated and stimulated with 1 μM angiotensin-II (Ang-II) 24 h. To increase interleukin 11 (IL-11) expression, overexpression plasmids transfected into fibroblasts. The role underlying mechanism IL-11 in examined by immunofluorescence, measurements reactive oxygen species (ROS) mitochondrial membrane (MMP), western...
Acute lung injury (ALI) is one of the fatal outcomes after exposure to high levels hydrogen sulfide (H2S), and matrix metalloproteinases (MMPs) especially MMP-2 MMP-9 are believed be involved in development ALI by degrading extracellular (ECM) blood-air barrier. However, roles H2S-induced mechanisms dexamethasone (DXM) treating clinical practice still largely unknown. The present work was aimed investigate protective effects DXM. In our study, SD rats were exposed H2S establish model...
The receptor-tyrosine-kinase (RTK)-like orphan receptor 1 (ROR1) is a transmembrane glycoprotein regarded as tumor-associated antigen. ROR1 plays an important role in cancer development, but the detailed function of diffuse large B-cell lymphoma (DLBCL) remains unclear. In this study, we first detected expression and evaluated relationship between clinicopathological characteristics DLBCL patients. Next employed shRNA-mediated knockdown cell line to explore development both vitro vivo....
Background/Aims: Resveratrol (Res), a polyphenol antioxidant found in red wine, has been shown to play cardioprotective role. This study was undertaken investigate whether Res can protect the heart suffering from hypertrophy injuries induced by isoproterenol (ISO), and protective effect is mediated endoplasmic reticulum (ER) stress. Methods: Cardiomyocytes were randomly assigned control group, ISO group (100 nM for 48 h), + (50 μM 100 h) 48h only). Hypertrophy estimated measuring cell...
Severe neurological inflammation is one of the main symptoms methamphetamine (meth)-induced brain injury. Studies have demonstrated that meth exposure facilitates neuroinflammation via Pellino E3 ubiquitin protein ligase 1 (Peli1)-mediated signaling. However, involved mechanisms remain incompletely understood. Herein, we used Peli1–/– mice and Peli1-knockdown microglial BV2 cells to decipher roles Peli1 downstream signaling in meth-induced neuroinflammation. After administration for seven...
The internal exposure dose of bisphenol S (BPS) is increasing since its use as a substitute for BPA. relationship between BPS and nonalcoholic liver disease (NAFLD) the underlying mechanism remain unclarified. In this study, we evaluated correlation with NAFLD in populations from Jiangsu Survey 2013–2016 National Health Nutrition Examination unraveled molecular pathway by which blocked hepatic autophagy, contributing to lipid accumulation. study found that serum urine were associated risks...
Brain damage following cerebral ischemia-reperfusion (I/R) is a complicated pathophysiological course, in which inflammation and oxidative stress have been suggested to serve an important role. Toll‑like receptor 4 (TLR4) has be involved secondary inflammatory process ischemia. Nuclear factor erythroid 2-related 2 (Nrf2), regulator of the antioxidant host defense, maintains cellular redox homeostasis. Tissue kallikrein (TK) proven elicit variety biological effects ischemic stroke through its...
Abstract To identify gene expression abnormalities in schizophrenia (SZ), we generated whole-genome profiles using microarrays on peripheral blood mononuclear cells (PBMCs) from 18 early-onset SZ cases and 12 controls. We detected 84 transcripts differentially expressed by diagnostic status, with 82 genes being upregulated 2 downregulated. identified two associated coexpression modules (green red), including 446 . The green module is positively correlated SZ, encompassing predominantly...