A5001022424- Sleep and Wakefulness Research
- Sleep and related disorders
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Neuroscience and Music Perception
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Obstructive Sleep Apnea Research
- Visual perception and processing mechanisms
- Restless Legs Syndrome Research
- Neural and Behavioral Psychology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Wind and Air Flow Studies
- Ophthalmology and Eye Disorders
- Sports Analytics and Performance
- Systemic Sclerosis and Related Diseases
- Epilepsy research and treatment
- Advanced Neuroimaging Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Neurological disorders and treatments
- Liquid Crystal Research Advancements
- Autoimmune Neurological Disorders and Treatments
- Aerodynamics and Fluid Dynamics Research
Harvard University
2018-2025
Massachusetts General Hospital
2018-2025
Athinoula A. Martinos Center for Biomedical Imaging
2018-2025
University of Patras
2022
National Technical University of Athens
2011-2015
National and Kapodistrian University of Athens
1996
Sleep has been shown to be critical for memory consolidation, with some research suggesting that certain memories are prioritized consolidation. Initial strength of a appears an important boundary condition in determining which consolidated during sleep. However, the role consolidation-mediating oscillations, such as sleep spindles and slow this preferential consolidation not explored. Here, 54 human participants (76% female) studied pairs words three distinct encoding strengths, recall...
Abstract Study Objectives Converging evidence from neuroimaging, sleep, and genetic studies suggest that dysregulation of thalamocortical interactions mediated by the thalamic reticular nucleus (TRN) contribute to autism spectrum disorder (ASD). Sleep spindles assay TRN function, their coordination with cortical slow oscillations (SOs) indexes communication. These mediate memory consolidation during sleep. In present study, we comprehensively characterized SOs in relation age children ASD....
Slow oscillations and sleep spindles, the canonical electrophysiological of nonrapid eye movement sleep, are thought to gate incoming sensory information, underlie processes sleep-dependent memory consolidation, altered in various neuropsychiatric disorders. Accumulating evidence predominantly local expression these individual oscillatory rhythms suggests that their cross-frequency interactions may have a similar component. However, it is unclear whether locally coordinated exist across...
Motivated by the potential of objective neurophysiological markers to index thalamocortical function in patients with severe psychiatric illnesses, we comprehensively characterized key non-rapid eye movement (NREM) sleep parameters across multiple domains, their interdependencies, and relationship waking event-related potentials symptom severity. In 72 schizophrenia (SCZ) 58 controls, confirmed a marked reduction spindle density SCZ extended these findings show that fast slow properties were...
Research on the role of hippocampus in memory acquisition has generally focused active learning. But to understand memory, it is at least as important processes that happen offline, during both wake and sleep. In a study patients with amnesia, we previously demonstrated although functional not necessary for procedural motor training session, required its offline consolidation Here, investigated whether an intact also while awake. Patients amnesia due hippocampal damage ( n = 4, all male)...
Rhythmic gymnastics (RG) is an aesthetic event balancing between art and sport that also has a performance rating system (Code of Points) given by the International Gymnastics Federation. It one sports in which competition results greatly depend on judges' evaluation. In current study, we explored five-gymnast ensemble routine.An expert-novice paradigm (10 international-level, 10 national-level, novice-level judges) was implemented under fully simulated procedure judgment routine RG using...
Abstract Sleep spindles, defining oscillations of non‐rapid eye movement stage 2 sleep (N2), mediate memory consolidation. Spindle density (spindles/minute) is a stable, heritable feature the electroencephalogram. In schizophrenia, reduced spindle correlates with impaired sleep‐dependent consolidation and promising treatment target. Measuring spindles also important for basic studies memory. However, overnight are expensive, time consuming require considerable infrastructure. Here we...
Critical aspects of motor learning and memory happen offline, during both wake sleep. When healthy young people learn a sequence task, most their performance improvement happens not while typing, but interleaved rest breaks. In contrast, the patients with dense amnesia due to hippocampal damage actually gets worse over breaks improves typing. These findings indicate that an intact hippocampus is necessary for offline wake, do specify its mechanism. Here, we studied epilepsy (n=17) undergoing...
Increased reaction time intra-subject variability (RT-ISV) in fast decision tasks has been confirmed patients with schizophrenia and hypothesized to result from a deficit the control of attention. Here, an attentional task functional brain imaging were used probe neural correlates increased RT-ISV schizophrenia. Thirty 30 age sex matched controls performed Eriksen flanker spatial attention concurrent measurement activity using magnetic resonance (fMRI). The behavioral measures included...
Abstract There is converging evidence that abnormal thalamocortical interactions contribute to attention deficits and sensory sensitivities in autism spectrum disorder (ASD). However, previous functional MRI studies of connectivity ASD have produced inconsistent findings terms both the direction (hyper vs. hypoconnectivity) location group differences. This may reflect, part, confounding effects head motion during scans. In present study, we investigated resting‐state 8–25 year‐olds with...
Abstract Sleep has been shown to be critical for memory consolidation, with some research suggesting that certain memories are prioritized consolidation. Initial strength of a appears an important boundary condition in determining which consolidated during sleep. However, the role consolidation-mediating oscillations, such as sleep spindles and slow this preferential consolidation not explored. Here, 54 human participants (76% female) studied pairs words three distinct encoding strengths,...
Abstract In oddball paradigms, infrequent stimuli elicit larger P300 event related potentials (ERPs) than frequent ones. One hypothesis is that modulations reflect the degree of “surprise” associated with unexpected stimuli. That represents how unlikely stimulus and this signal then used to update observer’s expectations. It could be hypothesized modulated by any factor affecting an expectations, not only target probability. Alternatively, may evaluative process engaged whenever a...
Healthy aging and many disorders show reduced sleep-dependent memory consolidation corresponding alterations in non-rapid eye movement sleep oscillations. Yet physiology remains a relatively neglected target for improving memory. We evaluated the effects of closed-loop auditory stimulation during (CLASS) on slow oscillations (SOs), spindles, their coupling, all relation to motor procedural consolidation. Twenty healthy young adults had two afternoon naps: one with SO upstates another no...
Multiple facets of sleep neurophysiology, including electroencephalography (EEG) metrics such as non-rapid eye movement (NREM) spindles and slow oscillations, are altered in individuals with schizophrenia (SCZ). However, beyond group-level analyses, the extent to which NREM deficits vary among patients is unclear, their relationships other sources heterogeneity clinical factors, ageing, cognitive profiles medication regimens. Using newly collected high-density EEG data on 103 SCZ 68...
Disrupted nighttime sleep (DNS) is common in pediatric Narcolepsy type 1, yet its cognitive impact unknown. As N2 spindles are necessary for sleep-dependent memory consolidation, we hypothesized that Type 1 impairs consolidation via fragmentation and spindle alterations.
Multiple facets of sleep neurophysiology, including electroencephalography (EEG) metrics such as non-rapid eye movement (NREM) spindles and slow oscillations (SO), are altered in individuals with schizophrenia (SCZ). However, beyond group-level analyses which treat all patients a unitary set, the extent to NREM deficits vary among is unclear, their relationships other sources heterogeneity clinical factors, illness duration ageing, cognitive profiles medication regimens. Using newly...