A5100318647- RNA Research and Splicing
- Genetic Associations and Epidemiology
- Obsessive-Compulsive Spectrum Disorders
- Sleep and Wakefulness Research
- Sleep and related disorders
- Epigenetics and DNA Methylation
- Autism Spectrum Disorder Research
- Bipolar Disorder and Treatment
- Bioinformatics and Genomic Networks
- Transcranial Magnetic Stimulation Studies
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Music Perception
- MicroRNA in disease regulation
- Alzheimer's disease research and treatments
- Gene expression and cancer classification
- Molecular Biology Techniques and Applications
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Tryptophan and brain disorders
- Eating Disorders and Behaviors
- Immune Cell Function and Interaction
- Health, Environment, Cognitive Aging
- Genetics and Plant Breeding
- Liquid Crystal Research Advancements
- Educational and Psychological Assessments
Jiangxi Mental Health Center
2024
Jiangnan University
2024
Nanjing Medical University
2014-2022
Wuxi People's Hospital
2014-2022
BACKGROUNDMajor depressive disorder (MDD) and posttraumatic stress (PTSD) are highly comorbid exhibit strong correlations with one another. We aimed to investigate mechanisms of underlying relationships between PTSD 3 kinds phenotypes, namely, MDD, depressed affect (DAF), depression (DEP, including both MDD the broad definition depression).METHODSGenetic phenotypes were tested using linkage disequilibrium score regression. Polygenic overlap analysis was used estimate shared trait-specific...
Motivated by the potential of objective neurophysiological markers to index thalamocortical function in patients with severe psychiatric illnesses, we comprehensively characterized key non-rapid eye movement (NREM) sleep parameters across multiple domains, their interdependencies, and relationship waking event-related potentials symptom severity. In 72 schizophrenia (SCZ) 58 controls, confirmed a marked reduction spindle density SCZ extended these findings show that fast slow properties were...
Transcriptional factors (TFs) and microRNAs (miRNAs) have been recognized as 2 classes of principal gene regulators that may be responsible for genome coexpression changes observed in schizophrenia (SZ). This study aims to (1) identify differentially coexpressed genes (DCGs) 3 mRNA expression microarray datasets; (2) explore potential interactions among the DCGs, expressed miRNAs identified our dataset composed early-onset SZ patients healthy controls; (3) validate levels some key...
Background: Previous findings are inconsistent; yet, converging evidence suggests an association between schizophrenia (SZ) and the impairment of posttranscriptional regulation brain development through microRNA (miRNA) systems. Methods: This study aims to (1) compare overall frequency 121 rare variants (RVs) in 59 genes associated with miRNA system genome-wide studies (GWAS)-derived data including 768 SZ cases 1348 healthy controls validated independent GWAS 1802 1447 controls; (2) profile...
Abstract To identify gene expression abnormalities in schizophrenia (SZ), we generated whole-genome profiles using microarrays on peripheral blood mononuclear cells (PBMCs) from 18 early-onset SZ cases and 12 controls. We detected 84 transcripts differentially expressed by diagnostic status, with 82 genes being upregulated 2 downregulated. identified two associated coexpression modules (green red), including 446 . The green module is positively correlated SZ, encompassing predominantly...
Abstract Schizophrenia (SZ) is a severe chronic mental disorder with high heritability. Current microarray analyses typically focus on identifying differentially expressed genes or enriched pathways relevant to phenotypes. Whether there variability change of the genomic transcription in diseases has rarely been explored. In this study, we compared coefficient variation (CV, ratio standard deviation mean) genome early-onset SZ (EOS) patients controls blood mRNA dataset and microRNA (miRNA)...
Repetitive transcranial magnetic stimulation (rTMS) is beneficial for treatment-resistant patients with obsessive-compulsive disorder (OCD). The serotonin transporter gene (SLC6A4) may be associated OCD. We aimed to determine whether SLC6A4 impacts the effects of rTMS in OCD treated selective reuptake inhibitors (SSRIs).Fifty-seven untreated were randomly assigned receive active or sham a 4-week double-blind study. participants received 1-Hz over supplementary motor area once per day, 5 days...
Schizophrenia (SZ) is a neurodevelopmental disorder in which altered immune function typically plays an important role mediating the effect of environmental insults and regulation inflammation. The breast cancer suppressor protein associated (BRAP) suggested to exert vital effects neurodevelopment by modulating mitogen-activated kinase cascade inflammation signaling. To explore possible BRAP SZ, we conducted two-stage study examine association polymorphisms with SZ Han Chinese population. In...
The onset of obsessive-compulsive disorder (OCD) involves the interaction heritability and environment. aim this study is to identify global messenger RNA (mRNA) expressed in peripheral blood from 30 patients with OCD paired healthy controls. We generated whole-genome gene expression profiles mononuclear cells (PBMCs) all subjects using microarrays. top 10 mRNAs was verified by real-time quantitative PCR (qRT-PCR) analysis. also performed an enrichment analysis ontology (GO) Kyoto...
Abstract Studies to date have reported hundreds of genes connected bipolar disorder (BP). However, many studies identifying candidate lacked replication, and their results have, at times, been inconsistent with one another. This paper, therefore, offers a computational workflow that can curate evaluate BP-related genetic data. Our method integrated large-scale literature data gene expression were acquired from both postmortem human brain regions (BP case/control: 45/50) peripheral blood...
Single-nucleotide polymorphism (SNP) is one of the most common sources genetic variations genome. Currently, SNPs are a main target for association studies. Visualizing genomic coordinates SNPs, including their physical location relative to host gene, and structure relevant transcripts, may provide intuitive supplements understanding functions. Nevertheless, date, no such easy-to-use programming tools exist. Therefore, we developed an R package, “mapsnp”, plot map panel within genome region...
Mild cognitive impairment (MCI) is a kind of non-functional decline between normal aging and dementia. With the increase individual age, quality function has become more important topic. The study gene loci in patients with MCI essential for prevention In this study, we evaluate polymorphism Chinese Han by propensity score matching (PSM) comparing them to healthy control (HC) subjects.Four hundred seventeen mild 508 people were included. two groups matched applying one-to-one PSM, tolerance...
Purpose This study aims to examine the potential influence of RS4680 ( COMT ), RS16965628 SLC6A4 and RS1019385 GRIN2B ) polymorphisms on therapeutic response repetitive transcranial magnetic stimulation (rTMS) selective serotonin reuptake inhibitors (SSRIs) in individuals with obsessive-compulsive disorder (OCD). Patients methods Thirty-six untreated outpatients diagnosed OCD were recruited allocated active or sham rTMS groups for two weeks. The mean age participants was 31.61, 17 males...
Researchers usually employ bar graphs to show two groups of data, which can be easily manipulated yield false impressions. To some extent, scatterplot retain the real data values and spread data. However, for numeric may cause over-plotting problems. As a result, many all stack on top each other. We recently implemented an R package, plot2groups, plot scatter points values, jittering adjacent side by avoid overlapping in plot. The functions simultaneously calculate P value group t- or...
Objectives: Dementia of the Alzheimer's type (DAT) is most common chronic neurodegenerative disease. At present, pathogenesis DAT not completely clear, and there are no drugs that can cure Once an individual diagnosed with DAT, survival time only 3 to 9 years. Therefore, urgent need determine etiology associated influencing factors find a breakthrough in treatment DAT. Methods: We studied relationship between polymorphisms several genes (including BIN1 APOE) susceptibility effects sex...
Abstract Motivated by the potential of objective neurophysiological markers to index thalamocortical function in patients with severe psychiatric illnesses, we comprehensively characterized key NREM sleep parameters across multiple domains, their interdependencies, and relationship waking event-related potentials symptom severity. In 130 schizophrenia (SCZ) controls, confirmed a marked reduction spindle density SCZ extended these findings show that only slow spindles predicted severity, fast...
Object To explore the difference of overgeneral autobiographical memory (OGM) between first-episode and recurrent depressive patients, whether can affect symptoms depression or not. Methods 34 patients 31 were enrolled. All measured by test(AMT), Hamilton Depression Scale-17 (HAMD-17) Beck rating scale(BDI). Results ①The OGM score was higher in group than that group(respectively, (3.90±1.65), ( 3.10±1.57), t=2.035, P<0.05). ②The positive (2.40±1.36), (1.70±1.08), t=2.308, ③The...