A5070278384- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Receptor Mechanisms and Signaling
- Autism Spectrum Disorder Research
- Renin-Angiotensin System Studies
- Birth, Development, and Health
- Kruppel-like factors research
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Neuroendocrine regulation and behavior
- Pituitary Gland Disorders and Treatments
- Sodium Intake and Health
- Biochemical Analysis and Sensing Techniques
- Obsessive-Compulsive Spectrum Disorders
- Attention Deficit Hyperactivity Disorder
- Hormonal Regulation and Hypertension
- Bipolar Disorder and Treatment
- Statistical Methods in Clinical Trials
- Dietary Effects on Health
- Meningioma and schwannoma management
- Diet and metabolism studies
- Ferroptosis and cancer prognosis
- Eating Disorders and Behaviors
- Adrenal Hormones and Disorders
- Effects and risks of endocrine disrupting chemicals
Medical College of Wisconsin
2020-2023
National Institute of Mental Health
2017-2018
National Institutes of Health
2017
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2013
Innsbruck Medical University
2013
LMU Klinikum
1987
GPCRs (G protein-coupled receptors) are implicated in blood pressure (BP) and fluid intake regulation. There is a developing concept that these effects mediated by both canonical G protein signaling noncanonical β-arrestin signaling, but the contributions of each remain largely unexplored. Here, we hypothesized contributes to homeostasis regulation deoxycorticosterone acetate (DOCA) salt hypertension, prototypical model salt-sensitive hypertension.Global β-arrestin1 (Arrb1) β-arrestin2...
Objective: The aim of this study was to identify any potential genetic overlap between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive (OCD). We hypothesized that since these disorders share a sub-phenotype, they may common risk alleles. In manuscript, we report the found two disorders. Methods: A meta-analysis conducted ADHD OCD, polygenic scores were calculated for both addition, protein-protein analysis completed in order examine interactions proteins; p-values...
Resting metabolic rate (RMR) adaptation occurs during obesity and is hypothesized to contribute failed weight management. Angiotensin II (Ang-II) type 1 (AT1A) receptors in Agouti-related peptide (AgRP) neurons the integrative control of RMR, deletion AT1A from AgRP causes RMR adaptation. Extracellular patch-clamp recordings identify distinct cellular responses individual lean mice Ang-II: no response, inhibition via Gαi, or stimulation Ang-II 2 (AT2) Gαq. Following diet-induced obesity, a...
Hypertension characterized by low circulating renin activity accounts for roughly 25%–30% of primary hypertension in humans and can be modeled experimentally via deoxycorticosterone acetate (DOCA)-salt treatment. In this model, phenotypes develop progressive phases, although the timelines relative contributions various mechanisms to phenotype development distinct between laboratories. To explore interactions among environmental influences such as diet formulation dietary sodium (Na) content...
The renin-angiotensin system (RAS) within the brain is implicated in control of fluid and electrolyte balance, autonomic functions, blood pressure, energy expenditure. Mouse models are increasingly used to explore these mechanisms; however, sex dose dependencies effects elicited by chronic intracerebroventricular (ICV) angiotensin II (ANG II) infusion have not been carefully established this species. To examine interactions among sex, body mass, ICV ANG on ingestive behaviors young adult...
A common preclinical model of hypertension characterized by low circulating renin is the "deoxycorticosterone acetate (DOCA)-salt" model, which influences blood pressure and metabolism through mechanisms involving angiotensin II type 1 receptor (AT1R) in brain. More specifically, AT1R within Agouti-related peptide (AgRP) neurons arcuate nucleus hypothalamus (ARC) has been implicated selected effects DOCA-salt. In addition, microglia have cerebrovascular DOCA-salt II. To characterize upon...
Syncytiotrophoblast stress is theorized to drive development of preeclampsia, but its molecular causes and consequences remain largely undefined. Multiple hormones implicated in preeclampsia signal via the Gαq cascade, leading hypothesis that excess signaling within syncytiotrophoblast may contribute. First, we present data supporting increased antioxidant responses villous samples human preeclamptic placenta. Second, was activated mouse placenta using Cre-lox DREADD methodologies....
Postnatal growth failure is a common morbidity for preterm infants and associated with adverse neurodevelopmental outcomes. Although sodium (Na) deficiency early in life impairs somatic growth, its impact on neurocognitive functions has not been extensively studied. We hypothesized that Na during sufficient to cause program neurobehavioral impairments later life. C57BL/6J mice were placed low- (0.4), normal- (1.5), or high- (3 g/kg) chow at weaning (
Abstract Studies to date have reported hundreds of genes connected bipolar disorder (BP). However, many studies identifying candidate lacked replication, and their results have, at times, been inconsistent with one another. This paper, therefore, offers a computational workflow that can curate evaluate BP-related genetic data. Our method integrated large-scale literature data gene expression were acquired from both postmortem human brain regions (BP case/control: 45/50) peripheral blood...
The brain renin-angiotensin system (RAS) is implicated in control of blood pressure (BP), fluid intake, and energy expenditure (EE). Angiotensin II (ANG II) within the arcuate nucleus hypothalamus contributes to resting metabolic rate (RMR) thereby EE through its actions on Agouti-related peptide (AgRP) neurons, which also contribute by leptin. First, we determined that although leptin stimulates littermates, mice with transgenic activation RAS (sRA) exhibit increased has no additive effect...
Ketoconazole (K), an antifungal agent, inhibits cortisol biosynthesis in human adrenal tissue by blocking 11β-hydroxylase activity [1]. Short-term administration of this imidazole derivative (1,000 mg/24 h) to five patients with Cushing’s syndrome and three controls showed a sharp rise the serum levels deoxycompounds 11-deoxycortisol (S) 11-deoxycorticosterone (DOC), but only slight decrease (F) clear-cut increase plasma ACTH In contrast these results, Sonino et al. found F levels,...
Background: RGS (regulator of G protein signaling) family members catalyze the termination signaling cascades. Single nucleotide polymorphisms in RGS2 gene humans have been linked to hypertension, preeclampsia, and anxiety disorders. Mice deficient for Rgs2 (Rgs2 Null ) exhibit anxiety, altered adipose development function. Methods: To study cell-specific functions RGS2, a novel gene-targeted mouse harboring conditional allele ( Flox was developed. These mice were bred with expressing...
Background: Approximately 8 % of all lung cancer is due to inherited factors. Risk more than doubles for those with relatives who have had cancer. To date, numerous genetic studies found large number genes that are related Most the focused on separate activities influence disease development.Methods: Literature data mining (LDM) over 17,884 articles publications from 1978 February 2016 was conducted. The reported multiple types marker-disease associations between 1,925 and A gene set...
Hintergrund: Die Wirksamkeit einer adjuvanten endokrinen Therapie mit Aromataseinhibitoren (AI), welche Im Fettgewebe von Androgenen in Östrogene umgewandelt werden, könnte abhängig sein vom Grad der Fettleibigkeit. Derzeit gibt es nur wenige Studien, die das pharmakokinetische Verhalten adipösen Frauen beobachtet. Ziel Studie ist den Zusammenhang zwischen Aromatasinhibitorserumspiegel und Fettleibigkeit zu klären.
Resting metabolic rate (RMR) adaptation contributes to the maintenance of human obesity, yet mechanisms controlling RMR in lean versus obese states remain poorly defined. Leptin control part through suppression inhibitory Agouti-related peptide (AgRP) neurotransmission hypothalamic arcuate nucleus (ARC). Within AgRP neurons, leptin activates extracellular signal-regulated kinase (ERK) cascade, which is thought interrupt Agrp transcription interference with Krüppel-like factor 4 (KLF4)...
Resting metabolic rate (RMR) accounts for ≈70% of energy expenditure in humans. Obesity induced by high fat diet (HFD) feeding is associated with “RMR adaptation” (i.e., reduced RMR relative to body size). We previously reported angiotensin II (ANG) receptors (AT1A) a subset neurons the arcuate nucleus hypothalamus (ARC) that express Agouti-related peptide (AgRP) are critically required integrative control RMR. Understanding signal mechanisms this unique RMR-controlling AgRP goal study, and...
Agouti-related peptide (AgRP/