A5000131579- Ocular Oncology and Treatments
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Prostate Cancer Treatment and Research
- Nanoplatforms for cancer theranostics
- melanin and skin pigmentation
- Ubiquitin and proteasome pathways
- Cancer Genomics and Diagnostics
- Chromatin Remodeling and Cancer
- Birth, Development, and Health
- MicroRNA in disease regulation
- Pregnancy and preeclampsia studies
Medical College of Wisconsin
2023
Sylvester Comprehensive Cancer Center
2016
University of Miami
2016
Uveal melanoma (UM) can be classified by gene expression profiling (GEP) into Class 1 (low metastatic risk) and 2 (high risk), the latter being strongly associated with mutational inactivation of tumor suppressor BAP1. Nevertheless, a small percentage tumors give rise to disease. The purpose this study was identify biomarkers metastasis in tumors.A total 389 consecutive patients UM were assigned or using prospectively validated 12-gene prognostic classifier. Selected further analyzed global...
Syncytiotrophoblast stress is theorized to drive development of preeclampsia, but its molecular causes and consequences remain largely undefined. Multiple hormones implicated in preeclampsia signal via the Gαq cascade, leading hypothesis that excess signaling within syncytiotrophoblast may contribute. First, we present data supporting increased antioxidant responses villous samples human preeclamptic placenta. Second, was activated mouse placenta using Cre-lox DREADD methodologies....
<p>Statistical, molecular, and survival analyses.</p>
<p>GViz integrated chromosomal visualization plots.</p>
<div>Abstract<p><b>Purpose:</b> Uveal melanoma (UM) can be classified by gene expression profiling (GEP) into Class 1 (low metastatic risk) and 2 (high risk), the latter being strongly associated with mutational inactivation of tumor suppressor BAP1. Nevertheless, a small percentage tumors give rise to disease. The purpose this study was identify biomarkers metastasis in tumors.</p><p><b>Experimental Design:</b> A total 389 consecutive patients...
<div>Abstract<p><b>Purpose:</b> Uveal melanoma (UM) can be classified by gene expression profiling (GEP) into Class 1 (low metastatic risk) and 2 (high risk), the latter being strongly associated with mutational inactivation of tumor suppressor BAP1. Nevertheless, a small percentage tumors give rise to disease. The purpose this study was identify biomarkers metastasis in tumors.</p><p><b>Experimental Design:</b> A total 389 consecutive patients...
<p>GViz integrated chromosomal visualization plots.</p>
<p>Statistical, molecular, and survival analyses.</p>