A5101957216- Genetic Associations and Epidemiology
- Alzheimer's disease research and treatments
- Genomic variations and chromosomal abnormalities
- Epigenetics and DNA Methylation
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Congenital heart defects research
- Diet and metabolism studies
- RNA Research and Splicing
- MicroRNA in disease regulation
- Genomics and Rare Diseases
- Computational Drug Discovery Methods
- Cognitive Abilities and Testing
- Cancer-related molecular mechanisms research
- Renin-Angiotensin System Studies
- Bioinformatics and Genomic Networks
- Cholesterol and Lipid Metabolism
- Cellular transport and secretion
- Optimism, Hope, and Well-being
- Phosphodiesterase function and regulation
- Phytoestrogen effects and research
- Histone Deacetylase Inhibitors Research
- Fibroblast Growth Factor Research
- Protein Degradation and Inhibitors
- Medicinal Plants and Bioactive Compounds
Yunnan Academy of Agricultural Sciences
2025
Wuxi People's Hospital
2014-2021
Nanjing Medical University
2014-2021
Jiangxi Mental Health Center
2013-2020
Institute of Psychology, Chinese Academy of Sciences
2016
Nanjing Brain Hospital
2016
Christie's
2016
BACKGROUNDMajor depressive disorder (MDD) and posttraumatic stress (PTSD) are highly comorbid exhibit strong correlations with one another. We aimed to investigate mechanisms of underlying relationships between PTSD 3 kinds phenotypes, namely, MDD, depressed affect (DAF), depression (DEP, including both MDD the broad definition depression).METHODSGenetic phenotypes were tested using linkage disequilibrium score regression. Polygenic overlap analysis was used estimate shared trait-specific...
Abstract Alzheimer’s disease (AD) is the most common cause of dementia in elderly. At early stages AD development, soluble β-amyloid (Aβ) induces synaptic dysfunction, perturbs excitation/inhibition balance neural circuitries, and turn alters normal network activity leading to cognitive decline, but underlying mechanisms are not well established. Here by using whole-cell recordings acute mouse brain slices, we found that 50 nM Aβ hyperexcitability excitatory pyramidal cells cingulate cortex,...
Abstract Phyllanthus emblica L. is an edible plant with medicinal properties native to the dry-hot valley of Yunnan, China. Here, we report a de novo chromosome-scale genome P. wild type “Yingyu”. “Yingyu” octopoid total 104 chromosomes. In total, assembled and clustered 480 Mb constructed 26 pseudochromosomes (haplotypes) that encompass 97.9% demonstrate have relatively high integrity. We annotated 31,111 genes found in emblica. screened five different tissues for searching tissue-specific...
Transcriptional factors (TFs) and microRNAs (miRNAs) have been recognized as 2 classes of principal gene regulators that may be responsible for genome coexpression changes observed in schizophrenia (SZ). This study aims to (1) identify differentially coexpressed genes (DCGs) 3 mRNA expression microarray datasets; (2) explore potential interactions among the DCGs, expressed miRNAs identified our dataset composed early-onset SZ patients healthy controls; (3) validate levels some key...
Background: Previous findings are inconsistent; yet, converging evidence suggests an association between schizophrenia (SZ) and the impairment of posttranscriptional regulation brain development through microRNA (miRNA) systems. Methods: This study aims to (1) compare overall frequency 121 rare variants (RVs) in 59 genes associated with miRNA system genome-wide studies (GWAS)-derived data including 768 SZ cases 1348 healthy controls validated independent GWAS 1802 1447 controls; (2) profile...
Schizophrenia (SCZ) is a severe psychiatric disorder associated with many different risk factors, both genetic and environmental. A recent genome-wide association study (GWAS) of Han Chinese identified three single-nucleotide polymorphisms (SNPs rs11038167, rs11038172, rs835784) in the tetraspanins gene TSPAN18 as possible susceptibility loci for schizophrenia. Hoping to validate these findings, we conducted case-control 1093 schizophrenia cases 1022 healthy controls. Using LDR-PCR method...
Abstract Schizophrenia (SZ) is a severe chronic mental disorder with high heritability. Current microarray analyses typically focus on identifying differentially expressed genes or enriched pathways relevant to phenotypes. Whether there variability change of the genomic transcription in diseases has rarely been explored. In this study, we compared coefficient variation (CV, ratio standard deviation mean) genome early-onset SZ (EOS) patients controls blood mRNA dataset and microRNA (miRNA)...
Repetitive transcranial magnetic stimulation (rTMS) is beneficial for treatment-resistant patients with obsessive-compulsive disorder (OCD). The serotonin transporter gene (SLC6A4) may be associated OCD. We aimed to determine whether SLC6A4 impacts the effects of rTMS in OCD treated selective reuptake inhibitors (SSRIs).Fifty-seven untreated were randomly assigned receive active or sham a 4-week double-blind study. participants received 1-Hz over supplementary motor area once per day, 5 days...
Abstract Background Schizophrenia is a chronic and severe mental disorder, it has been predicted to be highly polygenic. Common SNPs located in or near BNIP3L were found genome-wide significantly associated with schizophrenia recent association studies. The purpose of our study investigate potential causal variants gene. Results We performed targeted sequencing for all exons un-translated regions gene among 1806 patients 998 healthy controls Han Chinese origin. Three rare nonsynonymous...
Schizophrenia (SCZ) is a severe and heritable psychiatric disorder, previous studies have shown that regulation of the forkhead-box P2 gene (FOXP2) may play role in schizophrenia. Moreover, just few identified single nucleotide polymorphism (SNP) rs10447760 within was risk variant for SCZ Chinese Han population.To examine whether FOXP2 contributes toward susceptibility, we carried out an association analysis SNP case-control study (1405 cases, 1137 controls) from China.We no with (all...
Abstract Background The Reelin (RELN) gene encodes the protein reelin, which is a large extracellular matrix glycoprotein that plays key role in brain development. Additionally, this may be involved memory formation, neurotransmission, and synaptic plasticity, have been shown to disrupted schizophrenia (SCZ). A decreasing trend expression of RELN mRNA peripheral blood SCZ patients has observed. There need determine whether changes are result long-term antipsychotic treatment rather than...
Our previous study confirmed that the 'AA' genotype carriers of DISC1 single nucleotide polymorphism (SNP) rs821616 had a significantly increased risk for schizophrenia (SCZ) in comparison with noncarriers. To further explore relationship genetic variants SCZ Han Chinese, we designed present two-step study. We sequenced promoter and untranslated regions gene using genomic DNA 100 patients identified 17 SNPs. All SNPs were then genotyped analyzed through case-control 1154 healthy controls...
Schizophrenia (SCZ) is a complex, heritable, and devastating psychiatric disorder. Recent genome-wide association studies have identified single-nucleotide polymorphism (SNP; rs10503253) in the CUB SUSHI multiple domains 1 (CSMD1) gene as risk factor for SCZ. In this study, we investigated whether rs10503253 CSMD1 contributes to of SCZ Han Chinese population. We conducted case-control study population from eastern China, involving 1378 patients 1091 unrelated healthy controls, using ligase...
Schizophrenia (SCZ) is a common, complex and severe psychiatric disorder associated with many different genetic environmental risk factors. Evidence from studies has revealed the role of genome structural variations, specifically copy number variants (CNVs), in etiology SCZ. Nevertheless, occurrence CNVs their relation to SCZ remained relatively unstudied diverse Han Chinese population.We used case/control paradigm, including 476 cases 1023 controls. All samples were genotyped using Axiom®...
Lipid metabolism plays an important role in Alzheimer's disease (AD), and recent evidence suggests that single nucleotide polymorphisms (SNPs) the StAR-related lipid transfer domain 6 (STARD6) near enzyme enoyl CoA hydratase containing 3 (ECHDC3) gene are related to plasma levels or traits AD.To identify whether variants STARD6 ECHDC3 genes contribute AD susceptibility, we carried out association analysis of rs10164112 rs7920721 combination with apolipoprotein E (APOE) ε4 allele a...