A5013230389- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Autism Spectrum Disorder Research
- Tryptophan and brain disorders
- Genomic variations and chromosomal abnormalities
- Epigenetics and DNA Methylation
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- RNA Research and Splicing
- Diet and metabolism studies
- Genomics and Rare Diseases
- Folate and B Vitamins Research
- Child and Adolescent Psychosocial and Emotional Development
- Stress Responses and Cortisol
- Treatment of Major Depression
- Bioinformatics and Genomic Networks
- Neuroscience and Neuropharmacology Research
- Diabetes Treatment and Management
- Neural dynamics and brain function
- Suicide and Self-Harm Studies
- Ion channel regulation and function
- Phosphodiesterase function and regulation
Peking University
2016-2025
Chinese Institute for Brain Research
2019-2025
Peking University Sixth Hospital
2016-2025
Affiliated Hospital of North Sichuan Medical College
2024-2025
National Clinical Research
2018-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
McGovern Institute for Brain Research
2024
Henan Psychiatric Hospital
2022-2023
Xinxiang Medical University
2022-2023
Binzhou Medical University
2023
Abstract Background Numerous single nucleotide polymorphisms (SNPs) associated with complex diseases have been identified by genome-wide association studies (GWAS) and expression quantitative trait loci (eQTLs) studies. However, few of these SNPs explicit biological functions. Recent indicated that the within 3’UTR regions susceptibility genes could affect traits/diseases affecting function miRNAs. These are functional candidates therefore interest to GWAS eQTL researchers. Description We...
Past work on relatively small, single-site studies using regional volumetry, and more recently machine learning methods, has shown that widespread structural brain abnormalities are prominent in schizophrenia. However, to be clinically useful, imaging biomarkers must integrate high-dimensional data provide reproducible results across clinical populations an individual person basis. Using advanced multi-variate analysis tools pooled from case–control conducted at 5 sites (941 adult...
Observational studies have shown that oxidative stress is highly related to psychiatric disorders, while its cause−effect remains unclear. To this end, a Mendelian randomization study was performed investigate the causal relationship between and disorders. On one hand, all effects of injury biomarkers (OSIB) on disorders were not significant (p > 0.0006), findings suggested part OSIB nominally associated with risk (causal OR uric acid (UA), 0.999 for bipolar disorder (BD), 1.002...
Medication adherence of schizophrenic patients is a growing public health problem. We conducted meta-analysis on the influencing factors medication compliance in patients. searched PubMed, Embase, Cochrane Library, and Web Of Science for relevant articles published up to December 22, 2022. Combined odds ratios (ORs) 95% confidence intervals (CIs) were used assess factors. Egger's test, funnel plot, trim fill method, meta-regression analysis publication bias. A total 20 included analysis....
A growing body of research suggests that social or physical activity can affect the risk Major depressive disorder (MDD). However, bidirectional relationship between them remains to be clarified further, especially inactivity and MDD. Here, we performed a two-sample Mendelian Randomization analysis using genetic variants associated with social/physical activities MDD, assessed mediating effect obesity-related measures brain imaging phenotypes. The dataset on activities, included 500,199;...
Few new psychiatric drugs have entered the market in recent decades; contrast, number of carrying pharmacogenomic labels continues to increase. For foreseeable future, advancement psychiatry and drug therapy may hinge on personalized treatment. Currently, antipsychotic or antidepressant choices rely heavily clinical experience psychiatrists potentially lengthy iterative trials. During these trials, response treatment acutely depressed patients can be assessed only after several weeks...
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with strong genetic component. Many lines evidence indicated that ASD shares common variants other psychiatric (for example, schizophrenia). Previous studies detected calcium channels are involved in the etiology many including schizophrenia and autism. Significant association between CACNA1C (calcium channel, voltage-dependent, L type, alpha 1C subunit) was detected. Furthermore, rare mutation suggested to cause...
Autism spectrum disorders (ASDs) are a group of highly inheritable mental associated with synaptic dysfunction, but the underlying cellular and molecular mechanisms remain to be clarified. Here we report that autism in Chinese Han population is genetic variations copy number deletion P-Rex1 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1). Genetic or knockdown CA1 region hippocampus mice resulted autism-like social behavior was specifically linked defect long-term...
Abstract Background Evidence from functional and structural research suggests that abnormal brain activity plays an important role in the pathophysiology of schizophrenia (SZ). However, limited studies have focused on post-treatment changes, current conclusions are inconsistent. Study Design We recruited 104 SZ patients to resting-state magnetic resonance imaging scans at baseline 8 weeks treatment with second-generation antipsychotics, along scanning 86 healthy controls (HCs) for comparison...
Choosing the appropriate antipsychotic drug (APD) treatment for patients with schizophrenia (SCZ) can be challenging, as response to APD is highly variable and difficult predict due lack of effective biomarkers. Previous studies have indicated association between genetic epigenetic factors, but no biomarkers been identified. Hence, further research imperative enhance precision medicine in SCZ treatment.Participants were recruited from two randomized trials. The discovery cohort was CAPOC...
Abstract Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy subjects pooled across 41 international cohorts the ENIGMA, non-ENIGMA public datasets. Using Subtype Stage Inference (SuStaIn) algorithm, identify two distinct neurostructural subgroups by mapping spatial temporal ‘trajectory’ gray matter change in...
Abstract Schizophrenia is a chronic mental disorder primarily treated with antipsychotics, which have limited efficacy for negative symptoms. This study aims to evaluate the effectiveness and feasibility of exercise interventions as adjuncts pharmacotherapy through meta-analysis, providing valuable insights rational intervention design. Four databases were searched, randomized controlled trials no language restrictions published up March 27, 2023, included. The primary outcome indicator was...
Redox regulatory drug (RRD) targets may be considered potential novel of psychosis due to the fact that brain is highly susceptible oxidative stress imbalance. The aim present study identify associations between RRD targets’ perturbation and risk psychoses; achieve this, Mendelian randomization analyses were conducted. expression quantitative trait loci (eQTL) protein QTL data used derive genetic instrumental variables. We obtained latest summary genome-wide association studies on seven...
Abstract Background and Hypothesis The synaptic pruning hypothesis posits that schizophrenia (SCZ) autism spectrum disorder (ASD) may represent opposite ends of neurodevelopmental disorders: individuals with ASD exhibit an overabundance synapses connections while SCZ was characterized by excessive a reduction. Given the strong genetic predisposition both disorders, we propose shared component, certain loci having differential regulatory impacts. Study Design Genome-Wide single nucleotide...