A5025761726- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Schizophrenia research and treatment
- Radiomics and Machine Learning in Medical Imaging
- Mental Health Research Topics
- Medical Imaging Techniques and Applications
- Neural dynamics and brain function
- Genetic Associations and Epidemiology
- Neuroscience and Music Perception
- MRI in cancer diagnosis
- Tryptophan and brain disorders
- Transcranial Magnetic Stimulation Studies
- Electroconvulsive Therapy Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Bioinformatics and Genomic Networks
- Sleep and Wakefulness Research
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Imaging and Diagnostics
- Neural and Behavioral Psychology Studies
- Genetics and Physical Performance
- Signaling Pathways in Disease
- Treatment of Major Depression
- Bone and Joint Diseases
- Child and Adolescent Psychosocial and Emotional Development
Air Force Medical University
2016-2025
First Affiliated Hospital of Xi'an Jiaotong University
2023-2025
Chinese PLA General Hospital
2012-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2025
Xijing Hospital
2015-2023
University Medical Center Utrecht
2019
Xian Mental Health Center
2019
Xidian University
2017
Changsha Central Hospital
2015
X-Fab (Germany)
2015
Abstract Background Comorbidity between depressive and anxiety disorders is common. From network perspective, mental arise from direct interactions symptoms comorbidity due to depression symptoms. The current study investigates the structure of in Chinese female nursing students identifies central bridge as well how other present are related symptom “thoughts death”. Methods To understand full spectrum anxiety, we recruited 776 with that span range normal abnormal. Depression were measured...
Background In glioblastoma (GBM), promoter methylation of the DNA repair gene O ‐methylguanine‐DNA methyltransferase (MGMT) is associated with beneficial chemotherapy. Purpose/Hypothesis To analyze radiomics features for utilizing full potential medical imaging as biomarkers MGMT methylation. Study Type Retrospective. Population/Subjects all, 98 GBM patients known (48 methylated and 50 unmethylated tumors). Field Strength/Sequence 3.0T magnetic resonance (MR) images, containing T 1 ‐weighted...
Background Preoperative discrimination between nonmuscle‐invasive bladder carcinomas (NMIBC) and the muscle‐invasive ones (MIBC) is very crucial in management of patients with cancer (BC). Purpose To evaluate discriminative performance multiparametric MRI radiomics features for precise differentiation NMIBC from MIBC, preoperatively. Study Type Retrospective, radiomics. Population Fifty‐four postoperative pathologically proven BC lesions (24 30 MIBC groups) were included. Field...
The mental health burden among adolescents has been increasing, impacting individuals even before formal diagnosis of common disorders. Although personality traits, as key indicators conditions, play a crucial role in the development disorders, there is gap regarding trait-to-symptom pathways and similarities differences between young adults. A total 860 1751 adults participated this study. Chinese Big Five Personality Inventory assessed while depression anxiety symptoms were measured using...
Abstract Evidence from behavioral, electrophysiological and diffusion-weighted imaging studies suggest that schizophrenia patients suffer deficiencies in bilateral brain communication this disruption may be related to the occurrence of auditory verbal hallucinations (AVH). To increase our understanding aberrant inter-hemispheric relation AVH, we recruited two groups first-episode patients: one group with AVH (N = 18 patients) without Non-AVH 20 healthy controls. All participants received T1...
Specific biomarker reflecting neurobiological substrates of schizophrenia (SZ) is required for its diagnosis and treatment selection SZ. Evidence from neuroimaging has implicated disrupted functional connectivity in the pathophysiology. We aimed to develop validate a method disease definition SZ by resting-state using radiomics strategy. This study included 2 data sets collected with different scanners. A total 108 first-episode patients 121 healthy controls (HCs) participated current study,...
Purpose To investigate auditory verbal hallucination (AVH)–specific patterns of brain activity within the resting-state networks (RSNs) that have been proposed to underpin neural mechanisms schizophrenia (SZ). Materials and Methods This cross-sectional study was approved by local ethics committee, written informed consent obtained from all participants prospectively recruited. Independent component analysis used RSNs in 17 patients with first-episode untreated SZ AVHs, 15 without 19 healthy...
Abstract Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy subjects pooled across 41 international cohorts the ENIGMA, non-ENIGMA public datasets. Using Subtype Stage Inference (SuStaIn) algorithm, identify two distinct neurostructural subgroups by mapping spatial temporal ‘trajectory’ gray matter change in...
Understanding the neural basis of schizophrenia (SZ) is important for shedding light on neurobiological mechanisms underlying this mental disorder. Structural and functional alterations in anterior cingulate cortex (ACC), dorsolateral prefrontal (DLPFC), hippocampus, medial (MPFC) have been implicated neurobiology SZ. However, effective connectivity among them SZ remains unclear. The current study investigated how neuronal pathways involving these regions were affected first-episode using...
Abstract Studies comparing gray matter (GM) volume of schizophrenic patients with or without auditory verbal hallucinations (AVHs) to that normal controls remain controversial. This project aims investigate changes GM volumes drug-naïve and AVHs. Eighteen first episode (FES) AVHs, 18 FES AVHs healthy were scanned using structural MRI. Voxel-based morphometry (VBM) analysis was conducted among the three groups. Patients exhibited reduced relative in left superior temporal gyrus, frontal...
Abstract Emerging evidence indicates that a disruption in brain network organization may play an important role the pathophysiology of schizophrenia. The neuroimaging fingerprint reflecting first-episode schizophrenia remains to be identified. Here, we aimed at characterizing connectome medication-naïve patients with A cross-sectional structural and functional study using two independent samples (principal dataset including 42 medication-naïve, previously untreated 48 healthy controls;...
As a public health emergency of international concern as declared by the World Health Organization (WHO), current outbreak coronavirus disease (COVID-19) in China has captured world's attention.1 The global COVID-19 can now be characterized pandemic, and number confirmed cases all over world increased to 416 686 04:34 hours, 26 March 2020, according data released WHO.1 International journals for general medical specialty fields are working closely with experts across globe raise comment...
Abstract Background Inflammation has been implicated in the pathology of schizophrenia and may cause neuronal cell death dendrite loss. Neuroimaging studies have highlighted longitudinal brain structural changes patients with schizophrenia, yet it is unclear whether this related to inflammation. We aim address question, by relating transcriptional profile inflammation markers early stage schizophrenia. Methods Thirty-eight first-episode 51 healthy controls were included. High-resolution...
Abstract High suicide risk represents a serious problem in patients with major depressive disorder (MDD), yet treatment options that could safely and rapidly ameliorate suicidal ideation remain elusive. Here, we tested the feasibility preliminary efficacy of Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT) reducing MDD. Thirty-two MDD moderate to severe participated current study. Suicidal depression symptoms were assessed before after 5 days open-label SAINT. The neural...
Abstract Introduction Understanding the neural basis underlying major depressive disorder ( MDD ) is essential for diagnosis and treatment of this mental disorder. Aberrant activation functional connectivity default mode network DMN have been consistently found in patients with . It not known whether effective within altered Objects The primary object study to investigate during resting state before after eight weeks antidepressant treatment. Methods We defined four regions (medial frontal...
Abstract Introduction Treatment response at an early stage of schizophrenia is considerable value with regard to future management the disorder; however, there are currently no biomarkers that can inform physicians about likelihood response. Objects We aim develop and validate regional brain activity derived from functional magnetic resonance imaging (fMRI) as a potential signature predict treatment in schizophrenia. Methods Amplitude low‐frequency fluctuation (ALFF) was measured start...
Abstract Background Intolerance of uncertainty (IU) is considered as a specific risk factor in the development and maintenance generalized anxiety disorder (GAD). Yet, researches have investigated relations between IU GAD (or worry) using total scores on self-report measures. This ignores that there are different components exist heterogeneity symptoms. In present study, we explored among symptoms GAD. Methods A dimensional approach which take individual differences into consideration along...