A5100436753- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Autism Spectrum Disorder Research
- Schizophrenia research and treatment
- Mental Health Research Topics
- Genetics and Neurodevelopmental Disorders
- Attention Deficit Hyperactivity Disorder
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child and Adolescent Psychosocial and Emotional Development
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Advanced MRI Techniques and Applications
- Family and Disability Support Research
- Obsessive-Compulsive Spectrum Disorders
- Complex Network Analysis Techniques
- Mental Health and Psychiatry
- Tryptophan and brain disorders
- Traumatic Brain Injury Research
- Cognitive Abilities and Testing
- Transcranial Magnetic Stimulation Studies
- Neural Networks and Applications
- Opinion Dynamics and Social Influence
- Child Nutrition and Feeding Issues
- Bipolar Disorder and Treatment
Air Force Medical University
2023-2025
Hunan University of Traditional Chinese Medicine
2023-2025
Harbin Medical University
2025
Fudan University
2015-2024
Shanghai Center for Brain Science and Brain-Inspired Technology
2016-2024
Shanghai Institute for Science of Science
2016-2024
Central South University
2020-2024
Sichuan University
2020-2024
West China Hospital of Sichuan University
2020-2024
Guangzhou Medical University
2014-2024
The first brain-wide voxel-level resting state functional connectivity neuroimaging analysis of depression is reported, with 421 patients major depressive disorder and 488 control subjects. Resting between different voxels reflects correlations activity those a fundamental tool in helping to understand the brain regions altered function depression. One circuit involved medial orbitofrontal cortex Brodmann area 13, which implicated reward, had reduced memory systems parahippocampal gyrus...
Whole-brain voxel-based unbiased resting state functional connectivity was analysed in 418 subjects with autism and 509 matched typically developing individuals. We identified a key system the middle temporal gyrus/superior sulcus region that has reduced cortical (and increased medial thalamus), which is implicated face expression processing involved social behaviour. This ventromedial prefrontal cortex, emotion communication. The gyrus also theory of mind processing. second...
Wernicke's concept of 'sejunction' or aberrant associations among specialized brain regions is one the earliest hypotheses attempting to explain myriad symptoms in psychotic disorders. Unbiased data mining all possible brain-wide connections large sets an essential first step localizing these circuits.
Recent advances have demonstrated the effectiveness of a machine-learning approach known as "reservoir computing" for model-free prediction chaotic systems. We find that well-trained reservoir computer can synchronize with its learned systems by linking them common signal. A necessary condition achieving this synchronization is negative values sub-Lyapunov exponents. Remarkably, we show sending just scalar signal, one achieve synchronism in trained computers and cascading among their fitted...
The first voxel-level resting-state functional connectivity (FC) neuroimaging analysis of depression the anterior cingulate cortex (ACC) showed in 282 patients with major depressive disorder compared 254 controls, some higher, and lower FCs. However, 125 unmedicated patients, primarily increases FC were found: subcallosal lateral orbitofrontal cortex, pregenual/supracallosal medial parts inferior frontal gyrus, superior parietal lobule, early cortical visual areas. In 157 medicated these...
Abstract Generalized anxiety disorder (GAD) and panic (PD) are most common disorders with high lifetime prevalence while the pathophysiology disease‐specific alterations still remain largely unclear. Few studies have taken a whole‐brain perspective in functional connectivity (FC) analysis of these two resting state. It limits ability to identify regionally psychopathologically specific network abnormalities their subsequent use as diagnostic marker novel treatment strategy. The whole brain...
Pediatric refractory epilepsy is a broad phenotypic spectrum with great genetic heterogeneity. Next-generation sequencing (NGS) combined Sanger could help to understand the diversity and underlying disease mechanisms in pediatric epilepsy. Here, we report results from cohort of 172 patients aged 0–14 years. The pathogenicity identified variants was evaluated accordance American College Medical Genetics Genomics (ACMG) criteria. We 43 pathogenic or likely 40 (23.3%). Among these variants,...
Objective: Increased anxiety in response to the COVID-19 pandemic has been widely noted. The purpose of this study was test whether prepandemic functional connectome predicted individual induced by pandemic. Methods: Anxiety scores from healthy undergraduate students were collected during severe and remission periods (first survey, February 22–28, 2020, N=589; second April 24 May 1, N=486). Brain imaging data baseline (daily) ratings acquired before predictive performance on examined using...
Hemispheric lateralization constitutes a core architectural principle of human brain organization underlying cognition, often argued to represent stable, trait-like feature. However, emerging evidence underlines the inherently dynamic nature networks, in which time-resolved alterations functional remain uncharted. Integrating network approaches with concept hemispheric laterality, we map spatiotemporal architecture whole-brain large sample high-quality resting-state fMRI data ( N = 991,...
MDMA (3,4-methylenedioxymethamphetamine) is a psychoactive drug with powerful prosocial effects. While sometimes termed an "empathogen," empirical studies have struggled to clearly demonstrate these effects or pinpoint underlying mechanisms. Here, we paired the social transfer of pain and analgesia-behavioral tests modeling empathy in mice-with region-specific neuropharmacology, optogenetics, transgenic manipulations explore MDMA's action as empathogen. We report that MDMA, given...
Abstract Hyperkinetic disorders may involve excess excitatory output from thalamus to cerebral cortex. Case–control, neurophysiological studies in persons with Tourette Syndrome (TS), Attention Deficit Hyperactivity Disorder (ADHD), and Obsessive‐Compulsive (OCD) support this model. To compare the strength of association between motor cortex inhibition tic, ADHD, OCD severity TS, we used transcranial magnetic stimulation measure 36 children adults TS. Current symptom was assessed standard...
Creative thinking is a hallmark of human cognition, which enables us to generate novel and useful ideas. Nevertheless, its emergence within the macro-scale neurocognitive circuitry remains largely unknown. Using resting-state fMRI data from two large population samples (SWU: n = 931; HCP: 1001) "travelling pattern prediction analysis", here we identified modularized functional connectivity patterns linked creative ability, concurrently explained individual variability across ordinary...
High prevalence of sleep problems have been reported in children with Autism Spectrum Disorder (ASD). This study aims to investigate the conditions ASD China, and explore relationship between common core symptoms developmental levels.Using a cross-sectional design, we included 2 7-year-old from 13 cities China: 1310 1158 typically-developing (TD) children. The neurodevelopmental level was evaluated revised Children Neuropsychological Behavior Scale (CNBS-R2016). were diagnosed DSM-5 Child...
The orbitofrontal cortex (OFC) is implicated in depression. hypothesis investigated was whether the OFC sensitivity to reward and nonreward related severity of depressive symptoms. Activations monetary incentive delay task were measured IMAGEN cohort at ages 14 years (n = 1877) 19 1140) with a longitudinal design. Clinically relevant subgroups compared (high-severity group: n 116; low-severity 206) 14. medial exhibited graded activation increases reward, lateral had nonreward. In this...
The COVID-19 pandemic and lockdown will have short-term long-term psychosocial mental health implications for children. Children with autism may some specific needs support because of their difficulties in social communication, stereotyped behavior patterns, other specificities brought about by autism.The purpose this study was to investigate the impact on ASD children families.A total 406 parents completed an online survey investigating basic information; sleep, outdoor activities,...
Abstract Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy subjects pooled across 41 international cohorts the ENIGMA, non-ENIGMA public datasets. Using Subtype Stage Inference (SuStaIn) algorithm, identify two distinct neurostructural subgroups by mapping spatial temporal ‘trajectory’ gray matter change in...