A5020359914- Functional Brain Connectivity Studies
- Health, Environment, Cognitive Aging
- Genetic Associations and Epidemiology
- Advanced Neuroimaging Techniques and Applications
- Tryptophan and brain disorders
- Dementia and Cognitive Impairment Research
- Mental Health Research Topics
- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Nutritional Studies and Diet
- Genetics and Neurodevelopmental Disorders
- Genomics and Rare Diseases
- Biochemical Analysis and Sensing Techniques
- Sleep and related disorders
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Schizophrenia research and treatment
- Health disparities and outcomes
- Venous Thromboembolism Diagnosis and Management
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neural dynamics and brain function
- Diagnosis and Treatment of Venous Diseases
- Advanced MRI Techniques and Applications
- Cardiovascular Health and Risk Factors
- Autism Spectrum Disorder Research
Fudan University
2020-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2020-2025
Shanghai Institute for Science of Science
2020-2025
Huashan Hospital
2022-2025
Zhongshan Hospital
2024
State Key Laboratory of Medical Neurobiology
2022-2024
Institute of Science and Technology
2023
Douglas Mental Health University Institute
2023
McGill University
2023
Shanghai Innovative Research Center of Traditional Chinese Medicine
2022
<h3>Background and Objectives</h3> To investigate the independent associations of social isolation loneliness with incident dementia to explore potential neurobiological mechanisms. <h3>Methods</h3> We utilized UK Biobank cohort establish Cox proportional hazard models as separate exposures. Demographic (sex, age, ethnicity), socioeconomic (education level, household income, Townsend deprivation index), biological (body mass index, <i>APOE</i> genotype, diabetes, cancer, cardiovascular...
Developing a single-domain assay to identify individuals at high risk of future events is priority for multi-disease and mortality prevention. By training neural network, we developed disease/mortality-specific proteomic score (ProRS) based on 1461 Olink plasma proteins measured in 52,006 UK Biobank participants. This integrative markedly stratified the 45 common conditions, including infectious, hematological, endocrine, psychiatric, neurological, sensory, circulatory, respiratory,...
Abstract Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) define neuropsychopathological (NP) across externalizing internalizing symptoms using multitask connectomes. We demonstrate that NP might represent unified, genetically determined,...
Abstract Converging evidence increasingly implicates shared etiologic and pathophysiological characteristics among major psychiatric disorders (MPDs), such as schizophrenia (SZ), bipolar disorder (BD), depressive (MDD). Examining the neurobiology of psychotic-affective spectrum may greatly advance biological determination diagnosis, which is critical for development more effective treatments. In this study, ensemble clustering was developed to identify subtypes within a trans-diagnostic...
Background Previous prediction algorithms for cardiovascular diseases (CVD) were established using risk factors retrieved largely based on empirical clinical knowledge. This study sought to identify predictors among a comprehensive variable space, and then employ machine learning (ML) develop novel CVD model. Methods From longitudinal population-based cohort of UK Biobank, this included 473 611 CVD-free participants aged between 37 73 years old. We implemented an ML-based data-driven...
Childhood is a crucial neurodevelopmental period. We investigated whether childhood reading for pleasure (RfP) was related to young adolescent assessments of cognition, mental health, and brain structure.
Abstract The genetic contribution of protein-coding variants to immune-mediated diseases (IMDs) remains underexplored. Through whole exome sequencing 40 IMDs in 350,770 UK Biobank participants, we identified 162 unique genes 35 IMDs, among which 124 were novel genes. Several genes, including FLG is associated with atopic dermatitis and asthma, showed converging evidence from both rare common variants. 91 exerted significant effects on longitudinal outcomes (interquartile range Hazard Ratio:...
Abstract Previous genetic studies of venous thromboembolism (VTE) have been largely limited to common variants, leaving the determinants relatively incomplete. We performed an exome-wide association study VTE among 14,723 cases and 334,315 controls. Fourteen known four novel genes ( SRSF6 , PHPT1 CGN MAP3K2 ) were identified through protein-coding with broad replication in FinnGen cohort. Most we discovered exhibited potential predict future events longitudinal analysis. Notably, provide...
Abstract Iron plays a fundamental role in multiple brain disorders. However, the genetic underpinnings of iron and its implications for these disorders are still lacking. Here, we conduct an exome-wide association analysis iron, measured by quantitative susceptibility mapping technique, across 26 regions among 26,789 UK Biobank participants. We find 36 genes linked to with 29 not being previously reported, 16 them can be replicated independent dataset 3,039 subjects. Many involved transport...
Adolescents exhibit remarkable heterogeneity in the structural architecture of brain development. However, due to limited large-scale longitudinal neuroimaging studies, existing research has largely focused on population averages, and neurobiological basis underlying individual remains poorly understood. Here we identify, using IMAGEN adolescent cohort followed up over 9 years (14-23 y), three groups adolescents characterized by distinct developmental patterns whole-brain gray matter volume...
Socioeconomic status (SES) is a critical factor in determining health outcomes and influenced by genetic environmental factors. However, our understanding of the structure SES remains incomplete. Here, we conducted large-scale exome study markers (household income, occupational status, educational attainment, social deprivation) 350,770 individuals. For rare coding variants, identified 56 significant associations gene-based collapsing tests, unveiling 7 additional SES-associated genes ( NRN1...
The striatum, a core brain structure relevant for schizophrenia, exhibits heterogeneous volumetric changes in this illness. Due to heterogeneity, its role the risk of developing schizophrenia following exposure environmental stress remains poorly understood. Using putamen (a subnucleus striatum) as an indicator convergent genetic 63 unaffected first-degree relatives patients (22.08 ± 4.80 years) with (UFR-SZ) were stratified into two groups. Compared healthy controls (HC; n = 59),...
While increasing peripheral mechanisms related to chronic pain, the plasma proteomics profile associated with it and its prognosis remains elusive. This study utilizes 2923 proteins pain of 51 644 participants from UK Biobank finds 474 linked in six sites: head, neck or shoulder, back, stomach abdominal, hip, knee, 11 sharing across sites. The identified are largely enriched immune metabolic pathways highly expressed tissues like lungs small intestines. Phenome-wide analysis highlights...
A growing body of neuroimaging studies has reported common neural abnormalities among mental disorders in adults. However, it is unclear whether the distinct disorder-specific mechanisms operate during adolescence despite overlap disorders.We studied a large cohort more than 11 000 preadolescent (age 9-10 yr) children from Adolescent Brain and Cognitive Development cohort. We adopted regrouping approach to compare cortical thickness (CT) alterations longitudinal changes between healthy...
The cerebral ventricles are recognized as windows into brain development and disease, yet their genetic architectures, underlying neural mechanisms utility in maintaining health remain elusive. Here we aggregated neuroimaging data from 61,974 participants (age range, 9 to 98 years) five cohorts elucidate the basis of ventricular morphology examined overlap with neuropsychiatric traits. Genome-wide association analysis a discovery sample 31,880 individuals identified 62 unique loci 785...
Identification of individuals at high risk developing Parkinson disease (PD) several years before diagnosis is crucial for treatments to prevent or delay neurodegeneration. This study aimed develop predictive models PD that combine plasma proteins and easily accessible clinical-demographic variables.